Oxidation of Unsaturated Fatty Acids by Ozone and Nitrogen Dioxide

Evaluation of serum thiol levels in patients with non ST elevation acute coronary syndrome

“…Free radicals leading to oxidative stress are produced during the cell metabolism, or they are exogenous molecules with unpaired electrons (Freeman and Crapo, 1982;Lunec and Blake, 1990). Free radicals have been associated with occurrence, progression, and complications of many local and systemic diseases in the organism (Roehm et al, 1971). Their effects on myocardial infarction due to atherosclerosis, diabetes, cancer, cataracts, rheumatoid arthritis, infertility, respiratory diseases, diseases of the central nervous system and genitourinary system, and aging process have been reported by many researchers (Ak et al, 1994).…”

A new mechanism for ozonolysis of unsaturated organics on solids: phosphocholines on NaCl as a model for sea salt particles

“…[27][28][29][30][31] band is formed at B1110 cm À1 that is characteristic of the peroxide C-O bond 32,33 of the secondary ozonide ring (1,2,4-trioxolane, SOZ) known to be formed in ozone-alkene reactions. 14,[34][35][36][37][38][39][40] New bands at B1385 and 1347 cm À1 are also assigned to the SOZ. 31,33 The peak at 1210 cm À1 is assigned to a C-O moiety, although the specific species is not known.…”

Lipid Peroxidation and Antioxidative Protection Mechanism in Rat Lungs upon Acute and Chronic Exposure to Nitrogen Dioxide

“…Most likely, the alkyl free radicals can abstract hydrogen from unsaturated fatty acids, which leads to conventional autoxidation (4,5) (Eqs. [2][3][4][5]. The autoxidation reaction is effectively retarded by phenolic antioxidants such as a-tocopherol, butylated hydroxyanisole, and butylated hydroxytoluene, suggesting that Equation 5 is likely.…”

“…4) in the pathological examination of this study program. Therefore, the decrease of ethane exhalation of rats exposed to 4 ppm NO2 for 27 months may be partially due to the decrease of ventilatory capacity by lung fibrosis. However, such marked decrease of ethane exhalation might not be explained by only the decrease of ventilatory capacity.…”

“…The toxicity of NO2 is assumed to be related to lipid peroxidation of biomembranes, because NO2 readily attacks unsaturated lipid in lung tissue. A mechanism of lipid peroxidation reaction by NO2 is shown in equations [1][2][3][4][5] (2). Because the ethylene group of unsaturated fatty acids is readily attacked by NO2, the free radical species shown as I and II in Equation 1 are generated.…”