Oxidative and hydrolytic DNA cleavage by Cu(II) complexes of salicylidene tyrosine schiff base and 1,10 phenanthroline/bipyridine

Reddy, P. Rabindra; Shilpa, Addla

doi:10.1016/j.poly.2010.11.015

Cited by 50 publications

(23 citation statements)

References 47 publications

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“…The d-d band is observed around 600 nm in DMSO. Distorted square pyramidal geometry for copper(II) complexes has been proved by a broad band at around 600 nm [17]. This band is a characteristic of d-d transition in tetragonal field.…”

Section: Results and Discussion Electronic Spectra And Magnetismmentioning

confidence: 93%

“…After complexation disappearance of m(C=O) carb and shifting of m(C=O) p to lower values in the complexes (1619-1638) is the indication of coordination occurring through carbonyl oxygen of pyridine ring. The peaks corresponding to the ring stretching frequencies of m(C=N) of ligands were shifted to higher frequencies upon complexation indicating the coordination of the heterocyclic nitrogen atoms to the metal ion [17]. Bands are observed in the range 1560-1588 cm -1 and 1352-1379 cm -1 assigned as m(O-C-O) asymmetric and symmetric stretching vibrations, respectively.…”

Section: Ir Spectramentioning

confidence: 97%

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Copper(II) Complexes with N,O-Donor Ligands and Ofloxacin Drug as Antibacterial, DNA Interacting, Cytotoxic and SOD Mimic Agent

et al. 2015

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The N,O-donor bidentate ligands (L 1 -L 7 ) derived from the reaction between chalcones and pyridinium salt of 2-acetyl furan were synthesized and characterized by IR and NMR spectroscopic techniques. Their complexes [1][2][3][4][5][6][7] of Cu(II) were synthesized and characterized by elemental analysis, magnetic measurements, TG analyses, IR and mass spectroscopy. Synthesized complexes were carried out for their biological elucidation using different biological experiments like minimum inhibitory concentration, DNA binding and cleavage study, cytotoxicity, and antiradical activity. Efficient cleavage of pUC19 DNA was observed for all the test complexes than the reference drug. Graphical Abstract Increase in DNA chain length and hence the relative viscosity as the complexes binds to DNA via intercalative mode and involves a strong stacking interaction between an aromatic chromophore and the DNA base pair.Electronic supplementary material The online version of this article

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Section: Results and Discussion Electronic Spectra And Magnetismmentioning

confidence: 93%

Section: Ir Spectramentioning

confidence: 97%

Copper(II) Complexes with N,O-Donor Ligands and Ofloxacin Drug as Antibacterial, DNA Interacting, Cytotoxic and SOD Mimic Agent

et al. 2015

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“…In the IR spectra of CempBr and complexes 1-5, the strong bands at 1745 cm −1 are assigned to ester ν(C= O) and the medium bands around 1200 cm −1 are characterized for ν(O-C-O) vibrations. In addition, the electronic spectra of CempBr and complexes 1-5 exhibit strong absorption bands around 276 nm in 5 mm Tris-HCl buffer (5 mm NaCl, pH 7.0) that are assigned to π→ π* intra-ligand charge transfer transition 31) (Fig. S1).…”

Section: Resultsmentioning

confidence: 99%

Synthesis, Crystal Structures and DNA-Cleaving Activities of [Cemp]2[MCl4] (Cemp=N-Carbethoxymethyl-1,10-phenanthrolinium, M=CuII, ZnII, CoII, NiII and MnII)

Chen

Zhou

et al. 2013

CHEMICAL & PHARMACEUTICAL BULLETIN

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Key words quaternized 1,10-phenanthroline; transition metal complex; crystal structure; DNA cleavage Over the last few decades, transition metal complexes have been attracting considerable attentions in bioinorganic chemistry, because of their rich chemistry and wide potential applications, for example in creating of synthetic metallonucleases that are able to bind to and cleave DNA under physiological conditions. 1-3) As a consequence, many mono-, di-and multivalent transition metal complexes have been synthesized and found to efficiently catalyze the cleavage of DNA.4-6) Notable among them are those that are prepared from biocompatible endogenous metal ions, including Cu(II), Zn(II), Co(II), Ni(II) and Mn(II). Such metal complexes can create open coordination positions for DNA binding, and generate reactive oxygencontaining species or other radicals that may cause damage to the sugar and/or base of DNA. 7,8) For example, Zn(II) and Cu(II) complexes that are derived from a wide range of ligands, such as Schiff bases, 9) macrocyclic polyamines 10,11) and terpyridine derivatives, [12][13][14][15] have been found to act as effective catalysts for phosphodiester cleavage. In addition, Co(III), Mn(II) and Ni(II) complexes have also been reported to show high catalytic activities. [16][17][18][19] However, most of the complexes to date are confined to mono-, di-and multi-nuclear metal complexes, and ionic metal complexes in which the binding parts are separated from the cleaving centers, are less explored. 20,21) In constructing of metal complexes, 1,10-phenanthroline is an attractive building motif because it is well known that metal-bound planar phenanthroline complexes act as strong binders for double-stranded DNA and facilitate the hydrogen atom abstraction from the sugar unit. 22,23) For example, metal complexes of 1,10-phenanthroline and its conjugates with natural products possess interesting anti-cancer properties. 24)On the other hand, recent studies by us 25) and others [26][27][28][29][30] have indicated that metal complexes with functional ammonium groups exhibit significantly enhanced DNA-cleaving activities. These findings make us reasoning that the metal complexes of quaternized 1,10-phenanthroline derivatives may serve as potent DNA cleavers.

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“…Several authors have studied the influence of different activators on the cleavage of DNA by Cu(II) complexes 19 . In our work, we have found that hydrogen peroxide is the best activator for DNA cleavage.…”

Section: Chemical Nuclease Activitymentioning

confidence: 99%

Investigation of DNA binding mechanism, photoinduced cleavage activity, electrochemical properties and biological functions of mixed ligand copper(II) complexes with benzimidazole derivatives: synthesis and spectral characterization

Raman¹,

Selvan²

2011

Journal of Enzyme Inhibition and Medicinal Chemistry

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Oxidative and hydrolytic DNA cleavage by Cu(II) complexes of salicylidene tyrosine schiff base and 1,10 phenanthroline/bipyridine

Cited by 50 publications

References 47 publications

Copper(II) Complexes with N,O-Donor Ligands and Ofloxacin Drug as Antibacterial, DNA Interacting, Cytotoxic and SOD Mimic Agent

Copper(II) Complexes with N,O-Donor Ligands and Ofloxacin Drug as Antibacterial, DNA Interacting, Cytotoxic and SOD Mimic Agent

Synthesis, Crystal Structures and DNA-Cleaving Activities of [Cemp]<sub>2</sub>[MCl<sub>4</sub>] (Cemp=<i>N</i>-Carbethoxymethyl-1,10-phenanthrolinium, M=Cu<sup>II</sup>, Zn<sup>II</sup>, Co<sup>II</sup>, Ni<sup>II</sup> and Mn<sup>II</sup>)

Investigation of DNA binding mechanism, photoinduced cleavage activity, electrochemical properties and biological functions of mixed ligand copper(II) complexes with benzimidazole derivatives: synthesis and spectral characterization

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