Oxidative balance score and associations with dyslipidemia and mortality among US adults: A mortality follow‐up study of a cross‐sectional cohort

Kong, Xiufang; Gao, Xinghui; Wang, Wei

doi:10.1002/jpen.2661

Cited by 2 publications

References 40 publications

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Association of oxidative balance scores with all-cause and cardiovascular mortality in individuals with prediabetes and the mediating role of oxidative stress and systemic inflammation: Evidence from NHANES 1999-2018

Guo,

Liu,

Liu

et al. 2024

Preprint

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Background Oxidative stress may be relevant in the progression and cardiovascular complications of prediabetes. The oxidative balance score (OBS) is an emerging metric for assessing dietary and lifestyle oxidative stress exposure. The objective of this prospective cohort study from NHANES 1999–2018 was to explore the association of OBS with all-cause and cardiovascular disease (CVD) mortality in people with prediabetes. Methods OBS was composed of 16 dietary components and 4 lifestyle components based on previous research. Prediabetes was diagnosed based on self-reported history or laboratory criteria. Multivariate Cox proportional hazards regression analyses were used to explore these associations and calculate hazard ratios [HR] and 95% confidence intervals [CI]. Results A total of 8256 adult participants with prediabetes were included. Kaplan-Meier survival analysis showed significantly higher all-cause and CVD-related survival in people with prediabetes at higher OBS. After adjusting for all confounders, OBS, dietary OBS, and lifestyle OBS were all inversely associated with all-cause mortality in people with prediabetes (HR and 95% CI 0.959 (0.946,0.973), 0.965 (0.950,0.980), and 0.847 (0.798,0.899), respectively; all p < 0.0001). Higher OBS was associated with significantly lower all-cause mortality (p for trend all < 0.0001). Similar results were observed for CVD mortality. Most associations were linear, whereas the associations of OBS and dietary OBS with CVD mortality were nonlinear. Mediation analyses suggested that several oxidative stress and systemic inflammatory markers mediated these associations. Stratified and sensitivity analyses demonstrated the stability of the findings. Conclusions Adherence to antioxidant dietary and lifestyle patterns assessed by OBS may help prevent excess mortality in population with prediabetes. These effects may be achieved indirectly by influencing oxidative stress and systemic inflammatory markers.

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Association of oxidative balance scores with all-cause and cardiovascular mortality in individuals with prediabetes and the mediating role of oxidative stress and systemic inflammation: Evidence from NHANES 1999-2018

Guo,

Liu,

Liu

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

Association of oxidative balance score with cardiovascular disease and all-cause and cardiovascular mortality in American adults with type 2 diabetes: data from the National Health and Nutrition examination survey 1999-2018

Fan,

Song,

Chu

et al. 2024

Front. Endocrinol.

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BackgroundOxidative stress has an important role in type 2 diabetes (T2D). Oxidative balance score (OBS) is an emerging assessment of dietary and lifestyle oxidative balance. We aimed to explore the association of OBS with cardiovascular disease (CVD) and all-cause and CVD mortality in the T2D population through NHANES 1999-2018.MethodsOBS integrated 16 dietary components and 4 lifestyle components. T2D was diagnosed according to the American Diabetes Association criteria. Multivariate logistic regression and multivariate Cox proportional hazards regression analyses were used to explore the association of OBS with CVD and mortality in T2D, respectively.Results3801 adult T2D participants were included. In fully adjusted models, OBS, dietary OBS, and lifestyle OBS were all negatively associated with the prevalence of CVD (odds ratios of 0.98, 0.98, and 0.85, respectively). Higher OBS and lifestyle OBS (p for trend 0.016 and <0.001, respectively) rather than dietary OBS (p for trend = 0.06) were associated with significantly lower odds of CVD. Higher OBS, dietary OBS, and lifestyle OBS were all negatively associated with all-cause mortality (hazard ratios [HR] of 0.98, 0.98, and 0.92, respectively; p for trend of 0.002, 0.009, and 0.035, respectively). Higher OBS and dietary OBS were negatively associated with CVD mortality (HR 0.96 and 0.95, respectively; p for trend both <0.001), whereas lifestyle OBS was not. Restricted cubic spline analysis suggested that most associations were linear. Stratified analyses showed that these associations were influenced by some demographic variables and disease status.ConclusionsAdherence to higher OBS was associated with reduced CVD prevalence and mortality risk in T2D. Antioxidant diet and lifestyle had more significant associations with mortality and CVD prevalence, respectively. However, as these findings are merely associations and do not allow causal inferences to be drawn, future validation in high-quality randomized controlled trials is needed.

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Oxidative balance score and associations with dyslipidemia and mortality among US adults: A mortality follow‐up study of a cross‐sectional cohort

Cited by 2 publications

References 40 publications

Association of oxidative balance scores with all-cause and cardiovascular mortality in individuals with prediabetes and the mediating role of oxidative stress and systemic inflammation: Evidence from NHANES 1999-2018

Association of oxidative balance scores with all-cause and cardiovascular mortality in individuals with prediabetes and the mediating role of oxidative stress and systemic inflammation: Evidence from NHANES 1999-2018

Association of oxidative balance score with cardiovascular disease and all-cause and cardiovascular mortality in American adults with type 2 diabetes: data from the National Health and Nutrition examination survey 1999-2018

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