Oxidative balance score and dietary phytochemical index can reduce the risk of colorectal cancer in Iranian population

Abstract

Background No previous study has assessed the association between oxidative balance score (OBS) and dietary phytochemical index (DPI) with colorectal cancer (CRC) simultaneously. Therefore, this study investigated the association between OBS and DPI with the odds of CRC among the Iranian population. Methods This hospital-based age and sex-matched case–control study was conducted between September 2008 and January 2010 (142 controls and 71 cases were entered for analysis). New diagnosed CRC cases were selected from the Cancer Institute, Imam Khomeini Hospital of Tehran. Dietary intakes were determined by a semi-quantitative food frequency questionnaire (FFQ). Then, dietary indices were calculated by food items and nutrient intake. Logistic regression was utilized for assessing the tertiles of OBS and DPI. Results In multivariate analysis, OBS was associated with a 77% reduction in CRC odds in the last tertile than the first tertile (odds ratio (OR) = 0.23, confidence interval (CI): 0.07–0.72, Ptrend = 0.017). Also, we found a 64% reduction in CRC odds in the last tertile of DPI compared to the first tertile (OR = 0.36, CI: 0.15–0.86, Ptrend = 0.015). Conclusions A diet rich in phytochemicals and anti-oxidants, including fruits and vegetables (citrus fruits, colored berries, and dark-green leafy vegetables) and whole grains, may reduce the CRC odds.

The association between oxidative balance score and frailty in adults across a wide age spectrum: NHANES 2007–2018

“…Higher OBS obtained by summation was positively associated with total antioxidant capacity in participants. On the basis of previous studies, 29,30 we grouped the OBS into tertiles and defined the first tertile of the OBS as OBS Q1 (range: scores 3 to 16) and its second and third tertiles as OBS Q2 (range: scores 17 to 23) and OBS Q3 (range: scores 24 to 35), respectively.…”

Dietary and lifestyle indices for hyperinsulinemia and colorectal cancer risk: a case-control study

“…All subjects were required to provide written informed consent before the interview. Details of the current study have been previously published [ 16 , 17 ].…”

New insights into metabolic dysfunction-associated steatotic liver disease and oxidative balance score

“…The OBS was first proposed in 2002 in an epidemiologic study of a Belgian male smoking population, which used vitamin C and β-carotene as the antioxidant constituents and iron as the pro-oxidant constituent and showed that the lower the OBS score was, the higher the level of oxidative homeostasis in an individual, indicating that the lower the oxidative homeostasis score was, the higher the mortality rate in the population (15). Thereafter, numerous studies were conducted to investigate the relationship between OBS and a wide range of chronic disorders, such as type 2 diabetes mellitus (16), cardiovascular disease (17), and colorectal cancer (18). Recently, a study conducted in Iran showed that the greater the adherence to an OBS, the lower the odds of developing NAFLD (19).…”