Oxidative biodegradation of single- and multi-walled carbon nanotubes

Russier, Julie; Ménard‐Moyon, Cécilia; Venturelli, Enrica; Gravel, Edmond; Marcolongo, Gabriele; Meneghetti, Moreno; Doris, Eric; Bianco, Alberto

doi:10.1039/c0nr00779j

Cited by 166 publications

(175 citation statements)

References 27 publications

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“…Studies in vitro have shown the biodegradation of the oxidized-NTC by peroxidase enzymes such as horseradich peroxidase (HRP), human myeloperoxidase (MPO) and eosinophil peroxidase (EPO) under the presence of low concentration of H 2 O 2 and generating CO 2 as final product (Russier et al, 2011; . Zhao et al, 2011,Andon et al, 2013, Kotchey et al, 2013, Kagan et al, 2010.…”

Section: Biodegradation De Ntcmentioning

confidence: 99%

Carbon Nanotubes: a viable drug delivery platform for the treatment of cancer

Pinillos-Madrid¹,

Gallardo²

2015

J App Pharm Sci

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The development of new drug delivery platforms and specific vectorization processes for the treatment of diseases like cancer has become vitally important for the pharmaceutical industry. One of these new platforms are functionalized carbon nanotubes (f-CNTs), which are characterized by their high aspect ratio, high loading capacity, rich surface chemistry with functional groupsfor binding drugs and molecules. It has been demonstrated that functionalization processes of CNTs generate a marked decrease in toxicity, which makes them ideal candidates for clinical studies for their use as drug vectors.

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Section: Biodegradation De Ntcmentioning

confidence: 99%

Carbon Nanotubes: a viable drug delivery platform for the treatment of cancer

Pinillos-Madrid¹,

Gallardo²

2015

J App Pharm Sci

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“…On the other hand, today, there is no doubt that short, functionalized with polar moieties, and individualized MWCNTs offer a hope to be tested clinically [16]. But earlier in vitro [17] and in vivo [18] reports confirmed that, after functionalization, even >40 m long Fe@MWCNTs, providing individualized (i.e., not aggregated) nanotubes, could be considered as enzymatically degradable [19,20] and hence excretable drug vehicles [21].…”

Section: Introductionmentioning

confidence: 99%

Hybrids of Iron-Filled Multiwall Carbon Nanotubes and Anticancer Agents as Potential Magnetic Drug Delivery Systems: In Vitro Studies against Human Melanoma, Colon Carcinoma, and Colon Adenocarcinoma

Boncel

Pluta

Skonieczna

et al. 2017

Journal of Nanomaterials

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Cell type, morphology, and functioning are key variables in the construction of efficient "drug-vehicle" hybrids in magnetic drug delivery. Iron-encapsulated multiwall carbon nanotubes (Fe@MWCNTs) appear as promising candidates for theranostics due to in situ chemical catalytic vapor deposition (c-CVD) synthesis, straightforward organic functionalization, and nanoneedle (1D) behavior. Here, model hybrids were synthesized by exploring C-sp 2 chemistry ((1+2)-cycloaddition of nitrenes and amidation) of the outer MWCNT walls combined with anticancer agents, that is, 5-fluorouracil (5FU), purpurin (Purp), and 1,8-naphthalimide DNA intercalators (NIDIs), via linkers. Analyses of the Fe@MWCNT vehicles by SEM, TEM, and Raman spectroscopy revealed their morphology while Mössbauer spectroscopy confirmed the presence of encapsulated ferromagnetic iron-based nanodomains. Cytotoxicity of the hybrids was studied using a 24 h MTS assay combined with the apoptosis and life cycle assays against human melanoma (Me45), colon carcinoma (HCT116+), and colon adenocarcinoma (Caco-2). The cells had different sensitivity to the vehicles themselves as well as to the hybrids. MWCNT-based covalent hybrids of 5FU and Purp emerged as the most promising systems against Me45 and HCT116+ cell lines with the highest in vitro cytotoxicity and proapoptotic activity. Furthermore, nanotubes bearing 4-nitro-and 4-(N-morpholinyl)-1,8-naphthalimide DNA intercalators appear as a promising candidate for the treatment of Caco-2.

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“…An in vitro study has shown that SWNTs are oxidized and degraded more efficiently when compared to MWNTs. 105 In addition, SWNTs with surface carboxyl groups are degraded efficiently when compared to pristine, ozone-treated and aryl-sulfonated SWNTs. 106 A greater degree of carboxyl functionalization, which considerably improves the hydrophilicity of the CNTs, leads to an improved rate of degradation.…”

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confidence: 99%

Stealth nanotubes: strategies of shielding carbon nanotubes to evade opsonization and improve biodistribution

Kotagiri¹,

Kim²

2014

IJN

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Carbon nanotubes (CNTs) have recently been in the limelight for their potential role in disease diagnostics and therapeutics, as well as in tissue engineering. Before these medical applications can be realized, there is a need to address issues like opsonization, phagocytosis by macrophages, and sequestration to the liver and spleen for eventual elimination from the body; along with equally important issues such as aqueous solubility, dispersion, biocompatibility, and biofunctionalization. CNTs have not been shown to be able to evade such biological obstacles, which include their nonspecific attachments to cells and other biological components in the bloodstream, before reaching target tissues and cells in vivo. This will eventually determine their longevity in circulation and clearance rate from the body. This review article discusses the current status, challenges, practical strategies, and implementations of coating CNTs with biocompatible and opsonin-resistant moieties, rendering CNTs transparent to opsonins and deceiving the innate immune response to make believe that the CNTs are not foreign. A holistic approach to the development of such “stealth” CNTs is presented, which encompasses not only several biophysicochemical factors that are not limited to surface treatment of CNTs, but also extraneous biological factors such as the protein corona formation that inevitably controls the in vivo fate of the particles. This review also discusses the present and potential applications, along with the future directions, of CNTs and their hybrid-based nanotheranostic agents for multiplex, multimodal molecular imaging and therapy, as well as in other applications, such as drug delivery and tissue engineering.

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Oxidative biodegradation of single- and multi-walled carbon nanotubes

Cited by 166 publications

References 27 publications

Carbon Nanotubes: a viable drug delivery platform for the treatment of cancer

Carbon Nanotubes: a viable drug delivery platform for the treatment of cancer

Hybrids of Iron-Filled Multiwall Carbon Nanotubes and Anticancer Agents as Potential Magnetic Drug Delivery Systems: In Vitro Studies against Human Melanoma, Colon Carcinoma, and Colon Adenocarcinoma

Stealth nanotubes: strategies of shielding carbon nanotubes to evade opsonization and improve biodistribution

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