Oxidative burst of neutrophils against melanoma B16-F10

Živković, Morana; Poljak‐Blaži, Marija; Žarković, Kamelija; Mihaljevic, Danijela; Schaur, R. J.; Žarković, Neven

doi:10.1016/j.canlet.2006.02.002

Cited by 51 publications

(43 citation statements)

References 35 publications

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“…Because immune cells are sensitive to ROS-induced damage [53], high levels of ROS contribute to the impaired immune surveillance observed in patients with CLL [54,55]. For example, CLL patients with high ROS levels have reduced numbers of activated CD4+ cells and exposure to an antioxidant restores T-cell function [44].…”

Section: Oxidative Phosphorylation In Cllmentioning

confidence: 99%

Metabolism pathways in chronic lymphocytic leukemia

Rozovski

Hazan‐Halevy

Barzilai

et al. 2015

Leukemia & Lymphoma

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Alterations in CLL cell metabolism have been studied by several investigators. Unlike normal B lymphocytes or other leukemia cells, CLL cells, like adipocytes, store lipids and utilize free fatty acids (FFA) to produce chemical energy. None of the recently identified mutations in CLL directly affects metabolic pathways, suggesting that genetic alterations do not directly contribute to CLL cells’ metabolic reprogramming. Conversely, recent data suggest that activation of STAT3 or downregulation of microRNA-125 levels plays a crucial role in the utilization of FFA to meet CLL cells’ metabolic needs. STAT3, known to be constitutively activated in CLL, increases the levels of lipoprotein lipase that mediates lipoprotein uptake and shifts CLL cells’ metabolism towards utilization of FFA. Herein we review the evidence for altered lipid metabolism, increased mitochondrial activity, and formation of reactive oxygen species in CLL cells, and discuss possible therapeutic strategies to inhibit lipid metabolism pathways in patient with CLL.

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Section: Oxidative Phosphorylation In Cllmentioning

confidence: 99%

Metabolism pathways in chronic lymphocytic leukemia

Rozovski

Hazan‐Halevy

Barzilai

et al. 2015

Leukemia & Lymphoma

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“…We assume that autologous granulocytes would have lower effect on tumor growth than those collected from normal healthy donor. Namely, we found before that tumor transplantation causes granulocyte migration to the tumor site resulting in the reduced level of functionally active granulocytes circulating in the blood (Zivkovic et al, 2007). On the other hand, granulocytes that migrate to Sephadex papula have less pronounced inhibiting effect on tumor cell proliferation, when isolated on the 4th day after tumor transplantation, than those obtained from healthy animals (Zivkovic et al, 2005a).…”

Section: Discussionmentioning

confidence: 88%

“…In an earlier study using murine B16-F10 melanoma (Zivkovic et al, 2007), we have found that s.c. injection of Sephadex distracts the granulocytes from melanoma, allowing faster progression of the tumor, indicating that neutrophils may have an important role in the host defence against malignant cells in (Jaganjac et al, 2008). The results showed that innate immunity based on the immune competent granulocytes may be the cause of the well known phenomenon of spontaneous regression of W256 carcinoma in Sprague Dawley rats (Jaganjac et al, 2008).…”

Section: Introductionmentioning

confidence: 83%

“…In conclusion, granulocytes might play an important role in defence against cancer, manifested by the inflammatory response, causing oxidative stress at the site of tumor transplantation (Zivkovic et al, 2005a;Zivkovic et al, 2007;Jaganjac et al, 2008). The administration of granulocytes can lead to tumor regression or can slower tumor growth and extend the overall survival.…”

Section: Discussionmentioning

confidence: 99%

“…It was demonstrated that the activated granulocytes cause unspecific lysis of tumor cells mediated by ROS (Dallegri et al, 1991;van Kessel et al, 1990;Lichtenstein et al, 1989), hence ROS have been identified as effector molecules of the oxygendependent killing of cancer cells by granulocytes (Lichtenstein and Kahle, 1985;Lichtenstein et al, 1989). We have found that oxidative burst of granulocytes is cytotoxic for melanoma B16-F10 (Zivkovic et al, 2007) and for Walker 256 carcinoma (W256) (Zivkovic et al, 2005a). However, in spite of the data showing that granulocytes can participate in destruction of malignant cells, little is known about function of granulocytes in tumor-bearing hosts.…”

Section: Introductionmentioning

confidence: 99%

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Granulocytes as effective anticancer agent in experimental solid tumor models

et al. 2010

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Type IIFNs induce anti‐tumor polarization of tumor associated neutrophils in mice and human

Andzinski

Kasnitz

Stahnke

et al. 2015

Intl Journal of Cancer

323

308

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The importance of tumor associated neutrophils (TANs) in cancer development is in the meantime well established. Numerous of clinical data document the adverse prognostic effects of neutrophil infiltration in solid tumors. However, certain tumor therapies need functional neutrophils to be effective, suggesting altered neutrophil polarization associated with different outcomes for cancer patients. Therefore, modulation of neutrophilic phenotypes represents a potent therapeutic option, but factors mediating neutrophil polarization are still poorly defined. In this manuscript we provide evidence that type I IFNs alter neutrophilic phenotype into anti‐tumor, both in mice and human. In the absence of IFN‐β, pro‐tumor properties, such as reduced tumor cytotoxicity with low neutrophil extracellular traps (NETs) expression, low ICAM1 and TNF‐α expression, dominated neutrophil phenotypes in primary lesion and premetastatic lung. Interestingly, such neutrophils have significantly prolonged life‐span. Notably, interferon therapy in mice altered TAN polarization towards anti‐tumor N1. Similar changes in neutrophil activation could be observed in melanoma patients undergoing type I IFN therapy. Altogether, these data highlight the therapeutic potential of interferons, suggesting optimization of its clinical use as potent anti‐tumor agent.

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Oxidative burst of neutrophils against melanoma B16-F10

Cited by 51 publications

References 35 publications

Metabolism pathways in chronic lymphocytic leukemia

Metabolism pathways in chronic lymphocytic leukemia

Granulocytes as effective anticancer agent in experimental solid tumor models

Type IIFNs induce anti‐tumor polarization of tumor associated neutrophils in mice and human

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