Oxidative cleavage of DNA by a dipyridoquinoxaline copper(II) complex in the presence of ascorbic acid

Santra, Bidyut Kumar; Reddy, Pattubala A. N.; Neelakanta, Girish; Mahadevan, S.; Nethaji, Munirathinam; Chakravarty, Akhil R.

doi:10.1016/s0162-0134(01)00418-4

Cited by 158 publications

(97 citation statements)

References 29 publications

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“…4) 2+ complexes [47]. The Cu II /Cu I redox potentials of 1-3 depend upon the diimine co-ligand: dpq > phen > 5,6-dmp, reflecting the strong stabilization of Cu(I) oxidation state in [Cu I (imda)(dpq)] by the extensive p-delocalization involving Cu(I) and dpq ligand more than phen and stabilization of Cu(II) oxida- ; pulse height 50 mV.…”

Section: Electrochemistrymentioning

confidence: 99%

“…9D) and the slight quenching of cleavage reaction reveals that the complex prefers to bind to the minor groove [71] unlike the phen and 5,6-dmp analogues. Further, on treating [Cu(dpq) 2 ] 2+ with ascorbic acid a diamagnetic blue species of [Cu(dpq) 2 ] + was instantaneously precipitated [47]. On the other hand, treatment of [Cu(dpq) ( 2+ complexes bind at the minor groove of B-DNA and generates freely diffusible hydroxyl radical, which abstracts C1 hydrogen [72].…”

Section: Nuclease Activity Of Complexes and Mechanistic Investigationmentioning

confidence: 99%

See 1 more Smart Citation

Structures, spectra, and DNA-binding properties of mixed ligand copper(II) complexes of iminodiacetic acid: The novel role of diimine co-ligands on DNA conformation and hydrolytic and oxidative double strand DNA cleavage

Selvakumar

Rajendiran

Maheswari

et al. 2006

Journal of Inorganic Biochemistry

290

140

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Section: Electrochemistrymentioning

confidence: 99%

Section: Nuclease Activity Of Complexes and Mechanistic Investigationmentioning

confidence: 99%

Structures, spectra, and DNA-binding properties of mixed ligand copper(II) complexes of iminodiacetic acid: The novel role of diimine co-ligands on DNA conformation and hydrolytic and oxidative double strand DNA cleavage

Selvakumar

Rajendiran

Maheswari

et al. 2006

Journal of Inorganic Biochemistry

290

140

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“…[20] occasionally used to treat common as well as complicated urinary tract infections. It is sold under various brand names with the most common being Noroxin.…”

mentioning

confidence: 99%

Study on Newly Synthesized of Metal Heterochelates Based on Norfloxacin and Dicumarol Derivative: Biological Assessment

Patel¹

2017

WJPR

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“…69) Similar hydroxyl radical promoted DNA damages have been reported. 70) Furthermore, when the hydroxyl radical scavenger DMSO was added to the reaction mixture of 1, the cleavage reaction was inhibited, revealing that a freely diffusible hydroxyl radical is the reactive oxygen species directly responsible for initiation of cleavage reaction.…”

mentioning

confidence: 99%

Synthesis and Characterization of Glucose-Bis(pyrazole)-Cu(II)/Ni(II) Complexes and Their in Vitro DNA Binding Studies

Tabassum

Bhat

2010

CHEMICAL & PHARMACEUTICAL BULLETIN

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In the forefront is the recent area of glycobiology a "sweet and safe" approach for the development of new drugs in medicinal inorganic chemistry.1) The use of glycosyl substituents for enhanced tissue target, improved solubility and reduced toxicity has attracted many researchers to explore the possibility of carbohydrate-based drug strategies. [2][3][4][5] Chen et al. have synthesized a novel carbohydrate linked to cisplatin analogue, cis-dichloro [(2-b-D-glucopyranosidyl)propane-1,3-diamine]platinum and examined selective cytotoxicity towards cancer cells.6) This complex exhibits specific in vitro antitumour activity against human ovarian cancer cell A2780S and human melanoma cancer cell MeWo. Some of the cancer cell antigens are carbohydrates and several trials are being carried out to develop carbohydrate derived cancer vaccines.7) Globo H is a prominent epitope on cancer cells; therefore a potential vaccine was prepared consisting of the synthetic hexasaccharide chain of Globo H linked to KLH. 8)Recently, Nakase et al. have demonstrated artemisinin tagged to transferrin via carbohydrate chain exhibits high potency and specificity against cancer cells. 9) Carbohydrate linked to biologically relevant molecules like pyrazole and imidazole act as an attractive scaffold for transition metal ions. [10][11][12] The interaction of transition metal-saccharide complexes with DNA is significantly important (DNA is one of the main molecular targets in the action of anticancer drugs), as many naturally occurring antitumour agents are capable of modifying nucleic acids only in presence of metal ions and oxygen. [13][14][15][16] Of these antitumour agents, a vast majority usually contains sugar derivatives as their back bone. Thus, there has been profound interest in the design, study of DNA binding and cleavage properties of glucose-derived transition metal complexes and development of these complexes as metallo-drugs. 17,18) Since there are many alterations in the genes that code for the protein in tumor, the focus of such studies is also on proteins which drive and control cell cycle progression. 19,20) Herein, we describe the synthesis, characterization of Dglucose-bis pyrazolyl metal complexes of Cu(II) 1 and Ni(II) 2 and their binding properties with CT DNA. Furthermore, DNA cleavage of pBR322 DNA by complex 1 was carried out by employing agarose gel electrophoresis. The "binding study" of complex 1 towards human serum albumin (HSA), L-tryptophan and their mixtures with DNA was studied to recognize the most favoured biomolecule, for which it shows highest binding affinity. ExperimentalMaterials and Methods D-Glucose, CuCl 2 · 2H 2 O, NiCl 2 · 6H 2 O (Qualigens), pyrazole (Fluka). Tris (TrisϭTris(hydroxymethyl)aminomethane) base (Merck), 6ϫ loading dye (Fermental Life Science) and super coiled plasmid DNA pBR322 (Genei) were utilized as received. Disodium salt of calf thymus DNA, human serum albumin and L-tryptophan were purchased from Sigma Chemical Company and stored at 4°C. All reagent grade compounds were used w...

show abstract

Oxidative cleavage of DNA by a dipyridoquinoxaline copper(II) complex in the presence of ascorbic acid

Cited by 158 publications

References 29 publications

Structures, spectra, and DNA-binding properties of mixed ligand copper(II) complexes of iminodiacetic acid: The novel role of diimine co-ligands on DNA conformation and hydrolytic and oxidative double strand DNA cleavage

Structures, spectra, and DNA-binding properties of mixed ligand copper(II) complexes of iminodiacetic acid: The novel role of diimine co-ligands on DNA conformation and hydrolytic and oxidative double strand DNA cleavage

Study on Newly Synthesized of Metal Heterochelates Based on Norfloxacin and Dicumarol Derivative: Biological Assessment

Synthesis and Characterization of Glucose-Bis(pyrazole)-Cu(II)/Ni(II) Complexes and Their in Vitro DNA Binding Studies

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