Oxidative Damage and Bronchial Asthma

Babušíková, Eva; Jurečeková, Jana; Evinová, Andrea; Jeseňák, Miloš; Dobrota, Dušan

doi:10.5772/32132

Cited by 9 publications

(14 citation statements)

References 122 publications

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“…During the pre-exacerbation, the acceleration of the inflammatory cascades results in the asthma exacerbation of different severities ( 7 ). The persistent and intermittently exacerbated inflammation is accompanied by overproduction of reactive oxygen species (ROS) and reactive nitrogen species (RNS), which can also contribute to the promotion and persistence of the airway inflammation ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress and Bronchial Asthma in Children—Causes or Consequences?

2017

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Bronchial asthma is one of the most common chronic inflammatory diseases of the airways. In the pathogenesis of this disease, the interplay among the genes, intrinsic, and extrinsic factors are crucial. Various combinations of the involved factors determine and modify the final clinical phenotype/endotype of asthma. Oxidative stress results from an imbalance between the production of reactive oxygen species and reactive nitrogen species and the capacity of antioxidant defense mechanisms. It was shown that oxidative damage of biomolecules is strongly involved in the asthmatic inflammation. It is evident that asthma is accompanied by oxidative stress in the airways and in the systemic circulation. The oxidative stress is more pronounced during the acute exacerbation or allergen challenge. On the other hand, the genetic variations in the genes for anti-oxidative and pro-oxidative enzymes are variably associated with various asthmatic subtypes. Whether oxidative stress is the consequence of, or the cause for, chronic changes in asthmatic airways is still being discussed. Contribution of oxidative stress to asthma pathology remains at least partially controversial, since antioxidant interventions have proven rather unsuccessful. According to current knowledge, the relationship between oxidative stress and asthmatic inflammation is bidirectional, and genetic predisposition could modify the balance between these two positions—oxidative stress as a cause for or consequence of asthmatic inflammation.

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Section: Introductionmentioning

confidence: 99%

Oxidative Stress and Bronchial Asthma in Children—Causes or Consequences?

2017

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“…Increased amounts of ROS and RNS in the blood diminish antioxidant capacity [20]. Oxidative stress has been implicated in many pathological conditions, including asthma [21][22][23][24][25][26]. As the severity of illness increases, antioxidants are depleted to a greater extent [27].…”

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confidence: 99%

“…As the severity of illness increases, antioxidants are depleted to a greater extent [27]. The persistent and intermittently exacerbated inflammation is accompanied by overproduction of ROS and RNS, which may also contribute to the promotion and persistence of the airway inflammation in asthma [23].…”

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confidence: 99%

Differences in serum markers of oxidative stress in well controlled and poorly controlled asthma in Sri Lankan children: a pilot study

Fernando

Wickramasinghe

Silva

et al. 2020

Allergy Asthma Clin Immunol

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Background: Asthma is a disease characterised by hyper responsiveness and bronchoconstriction of airways, and is a major health burden globally. A dysfunction of the oxidant-antioxidant balance, termed oxidative stress, has been implicated in the pathophysiology of asthma. The present study aims to assess the changes in oxidative stress markers, namely nitric oxide metabolites and antioxidant capacity, in children with poorly controlled and well controlled asthma, in comparison to healthy controls. Methods: The present study enrolled 72 children (ages 5-15 years) classified into three groups: (1) poorly controlled asthma (n = 20), (2) well controlled asthma (n = 24) and (3) healthy controls (n = 27). An interviewer-administered questionnaire was used to record socio-demographic data of the participants. The serum concentrations of the oxidant markers (nitrite, nitrate and total nitric oxide metabolites [NO x ]) were determined using the Griess test, and the total antioxidant capacity (TAOC) was determined using the ABTS decolorisation method. The concentrations of these markers were compared across the three groups. Results: The three study groups were similar in terms of socio-demographic data. The differences across the three groups were statistically significant for serum concentrations of nitrate and NO x (but not nitrite) and serum TAOC. Further analyses showed that the disparity for nitrate and NO x concentrations was greatest between poorly controlled asthma and healthy controls (p = 0.001 and p < 0.001) compared to the well-controlled asthmatics and healthy controls (p = 0.036 and p = 0.049). A significant difference in serum nitrate and NO x concentrations was not observed between the two asthma groups (p = 0.311 and 0.203). The TAOC were significantly lower in poorly controlled asthmatics as compared to well-controlled asthmatics (p = 0.003) and healthy controls (p < 0.001). However, there was no significant difference in the serum TAOC between healthy controls and well-controlled asthmatics (p = 0.496). These findings may indicate that it is perhaps the higher TAOC that contributes to the well controlled state of asthma. Conclusions: The present study indicated that an imbalance of oxidants and antioxidants in the serum may have an underlying role in asthma pathophysiology, and how these markers may be effective in asthma management.

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“…Despite nonsignificant differences in the genotype distributions, the two-locus comparison of genotype frequencies between the study groups has shown that asthma patients more often than healthy subjects carry combinations of the genotypes which are known to determine a diminished activity of ADE towards ROS. This is supported by a number biochemical studies that observed massive generation of ROS and the insufficiency in antioxidant capacity in asthma [ 65 – 68 ]. In this context, it is important to highlight that the studied ADE genes alone cannot account for the whole polygenic mechanisms underlying such biochemical abnormalities in asthma.…”

Section: Discussionmentioning

confidence: 69%

“…This is supported by a number biochemical studies that observed massive generation of ROS and the insufficiency in antioxidant capacity in asthma [65–68]. In this context, it is important to highlight that the studied ADE genes alone cannot account for the whole polygenic mechanisms underlying such biochemical abnormalities in asthma.…”

Section: Discussionmentioning

confidence: 90%

Antioxidant Defense Enzyme Genes and Asthma Susceptibility: Gender-Specific Effects and Heterogeneity in Gene-Gene Interactions between Pathogenetic Variants of the Disease

Polonikov

Иванов

Богомазов

et al. 2014

BioMed Research International

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Oxidative stress resulting from an increased amount of reactive oxygen species and an imbalance between oxidants and antioxidants plays an important role in the pathogenesis of asthma. The present study tested the hypothesis that genetic susceptibility to allergic and nonallergic variants of asthma is determined by complex interactions between genes encoding antioxidant defense enzymes (ADE). We carried out a comprehensive analysis of the associations between adult asthma and 46 single nucleotide polymorphisms of 34 ADE genes and 12 other candidate genes of asthma in Russian population using set association analysis and multifactor dimensionality reduction approaches. We found for the first time epistatic interactions between ADE genes underlying asthma susceptibility and the genetic heterogeneity between allergic and nonallergic variants of the disease. We identified GSR (glutathione reductase) and PON2 (paraoxonase 2) as novel candidate genes for asthma susceptibility. We observed gender-specific effects of ADE genes on the risk of asthma. The results of the study demonstrate complexity and diversity of interactions between genes involved in oxidative stress underlying susceptibility to allergic and nonallergic asthma.

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Oxidative Damage and Bronchial Asthma

Cited by 9 publications

References 122 publications

Oxidative Stress and Bronchial Asthma in Children—Causes or Consequences?

Oxidative Stress and Bronchial Asthma in Children—Causes or Consequences?

Differences in serum markers of oxidative stress in well controlled and poorly controlled asthma in Sri Lankan children: a pilot study

Antioxidant Defense Enzyme Genes and Asthma Susceptibility: Gender-Specific Effects and Heterogeneity in Gene-Gene Interactions between Pathogenetic Variants of the Disease

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