Oxidative damage in metal fragment-embedded Sprague-Dawley rat gastrocnemius muscle

Kalinich, John F.; Vergara, Vernieda B.; Hoffman, Jessica F.

doi:10.1016/j.crtox.2022.100083

Cited by 2 publications

(1 citation statement)

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“…Studies have shown that contact with CoNPs raises oxidative stress levels in rat muscle tissue, resulting in muscle tissue damage [ 39 ]. In zebrafish embryos, exposure to high concentrations of CoNPs is toxic and negatively impacts development [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Selenium Nanoparticles Attenuate Cobalt Nanoparticle-Induced Skeletal Muscle Injury: A Study Based on Myoblasts and Zebrafish

Tan,

Deng,

Jiang

et al. 2024

Toxics

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Cobalt alloys have numerous applications, especially as critical components in orthopedic biomedical implants. However, recent investigations have revealed potential hazards associated with the release of nanoparticles from cobalt-based implants during implantation. This can lead to their accumulation and migration within the body, resulting in adverse reactions such as organ toxicity. Despite being a primary interface for cobalt nanoparticle (CoNP) exposure, skeletal muscle lacks comprehensive long-term impact studies. This study evaluated whether selenium nanoparticles (SeNPs) could mitigate CoNP toxicity in muscle cells and zebrafish models. CoNPs dose-dependently reduced C2C12 viability while elevating reactive oxygen species (ROS) and apoptosis. However, low-dose SeNPs attenuated these adverse effects. CoNPs downregulated myogenic genes and α-smooth muscle actin (α-SMA) expression in C2C12 cells; this effect was attenuated by SeNP cotreatment. Zebrafish studies confirmed CoNP toxicity, as it decreased locomotor performance while inducing muscle injury, ROS generation, malformations, and mortality. However, SeNPs alleviated these detrimental effects. Overall, SeNPs mitigated CoNP-mediated cytotoxicity in muscle cells and tissue through antioxidative and antiapoptotic mechanisms. This suggests that SeNP-coated implants could be developed to eliminate cobalt nanoparticle toxicity and enhance the safety of metallic implants.

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Section: Discussionmentioning

confidence: 99%