Oxidative damage induced by copper and beta-cypermethrin in gill of the freshwater crayfish Procambarus clarkii

Wei, Keqiang; Yang, Junxian

doi:10.1016/j.ecoenv.2014.12.032

Cited by 65 publications

(22 citation statements)

References 36 publications

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“…The cells generally maintain essential functions by promoting or inhibiting synthesis or degradation of proteins 41 , however, under stress, protein degradation becomes a key process for production of ATP, liberation of amino acids and other substances for gluconeogenesis, synthesis of antioxidants and detoxification enzymes and to meet the energy demands 42 – 44 . TCS is known to induce ROS generation in organisms 13 , 45 which cause carbonyl protein formation and as a result of this, there is change in the conformation of proteins, increase in photolytic susceptibility and decline in enzyme activity 38 , 46 . Less intake of feed by the exposed hatchlings seems to be an additional factor for further decline in protein content during the post exposure period.…”

Section: Discussionmentioning

confidence: 99%

Biomarkers for the toxicity of sublethal concentrations of triclosan to the early life stages of carps

Dar

Sharma

Singh

et al. 2020

Sci Rep

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Accumulation, contents of protein, non-enzymatic antioxidant glutathione (GSH and GSSG), lipid peroxidation product (melondialdehyde-MDA) and organic acids (fumarate, succinate, malate and citrate), and activities of neurological (acetylcholinesterase-AChE), detoxification (glutathione S-transferase-GST) and metabolic (lactate dehydrogenase-LDH, aspartate transaminase-AST and alanine transaminase-ALT) enzymes were recorded in the hatchlings of Cyprinus carpio, Ctenopharyngodon idella, Labeo rohita and Cirrhinus mrigala after 7 and 14 days exposure and 10 days post exposure (recovery period) to sublethal concentrations (0.005, 0.01, 0.02 and 0.05 mg/L) of triclosan, a highly toxic and persistent biocide used in personal care products. Accumulation was maximum between 7–14 days at 0.01 mg/L for C. carpio and L. rohita but at 0.005 mg/L for C. idella and C. mrigala. No triclosan was observed at 0.005 mg/L in C. carpio and C. mrigala after recovery. Significant decline in protein, glutathione and acetylcholinesterase but increase in glutathione S-transferase, lactate dehydrogenase, aspartate transaminase, alanine transaminase, melondialdehyde and organic acids over control during exposure continued till the end of recovery period. Integrated biomarker response (IBR) analysis depicted higher star plot area for glutathione and glutathione S-transferase during initial 7 days of exposure, thereafter, during 7–14 days of exposure and the recovery period, higher star plot area was observed for acetylcholinesterase, aspartate transaminase, alanine transaminase and organic acids. Higher star plot area was observed for protein in all the species throughout the study. The study shows that L. rohita is most sensitive and glutathione, acetylcholinesterase, aspartate transaminase and alanine transaminase are the biomarkers for the toxicity of sublethal concentrations of TCS.

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Section: Discussionmentioning

confidence: 99%

Biomarkers for the toxicity of sublethal concentrations of triclosan to the early life stages of carps

Dar

Sharma

Singh

et al. 2020

Sci Rep

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“…When the production of ROS in cell exceeds the antioxidant generation, excessive ROS can destroy biomolecules through free radical attaches to polyunsaturated fatty acid side chains in cell membranes and it leads to LPO [32]. LPO is a highly destructive process that increases the rigidity and decreases the fluidity of cellular membranes [53]. It has been reported that the levels of MDA increased as a result of oxidation of lipoprotein and lipids in cell membranes during oxidative stress [47,54].…”

Section: Discussionmentioning

confidence: 99%

The Change of Metallothionein and Oxidative Response in Gills of the Oreochromis niloticus after Exposure to Copper

Ma’rifah

Saputri

Soegianto

et al. 2019

Animals

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In the present study, we investigated the effects of waterborne copper (Cu) on the levels of metallothionein (MT) and malondialdehyde (MDA), as well as activities of superoxide dismutase (SOD) and catalase (CAT) in gills of cichlid fish Oreochromis niloticus. The Cu concentrations in gills were measured using an atomic absorption spectrometer. The sandwich-ELISA was used to measure MT, SOD, CAT, and MDA. The Cu concentrations in gills of fish that were exposed to 1, 5, and 10 mg Cu/L were significantly increased at day 1 (D1), then gradually decreased starting from D2, and reaches the similar value with the controls at D5. A similar tendency has been observed in the MT levels in the gills. All of the Cu-exposed fish showed the highest level of MT on D1, and then decreased at D3 and a plateau at D4 and D5. The levels of SOD and CAT in gills in all Cu-exposed fish showed a similar pattern: increased significantly at D1, then gradually decreased starting from D2, and increased again at D4 and D5. The levels of MDA in gills of all Cu-exposed fish showed no significant difference. The indifference levels of MDA in gills of all Cu-exposed fish suggested the antioxidant defense systems (SOD and CAT) combined with the induction of MT were able to completely scavenge the increased ROS.

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“…Considering their distances from MRC, other sources of contaminants may be responsible for the low dissolved oxygen, high levels of Cr in the water, low condition factor of the fish in SS reservoir, as well as toxic concentrations of Pb, Cu, and Zn in the sediment, and Pb in the muscle in SO reservoir. These metals may lead to gills dysfunction, oxidative damage (Wei and Yang, 2015), apoptosis (Luzio et al 2013;Monteiro et al 2009), and neurotoxicity (White et al 2007).…”

Section: Physicochemical Parameters Are Not Enough To Predict the Chementioning

confidence: 99%

Bioavailability of pollutants sets risk of exposure to biota and human population in reservoirs from Iguaçu River (Southern Brazil)

Yamamoto

Pereira

Lottermann

et al. 2016

Environ Sci Pollut Res

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The Iguaçu River, located at the Southern part of Brazil, has a great socioeconomic and environmental importance due to its high endemic fish fauna and its potential to generate hydroelectric power. However, Iguaçu River suffers intense discharge of pollutants in the origin of the river. In a previous report, the local environmental agency described water quality to improve along the river course. However, no study with integrated evaluation of chemical analysis and biological responses has been reported so far for the Iguaçu River. In the current study, three different Brazilian fish species (Astyanax bifasciatus, Chrenicicla iguassuensis, and Geophagus brasiliensis) were captured in the five cascading reservoirs of Iguaçu River for a multi-biomarker study. Chemical analysis in water, sediment, and muscle indicated high levels of bioavailable metals in all reservoirs. Polycyclic aromatic hydrocarbons (PAHs) were detected in the bile of the three fish species. Integration of the data through a FA/PCA analysis demonstrated the poorest environmental quality of the reservoir farthest from river's source, which is the opposite of what has been reported by the environmental agency. The presence of hazardous chemicals in the five reservoirs of Iguaçu River, their bioaccumulation in the muscle of fish, and the biological responses showed the impacts of human activities to this area and did not confirm a gradient of pollution between the five reservoirs, from the source toward Iguaçu River's mouth. Therefore, diffuse source of pollutants present along the river course are increasing the risk of exposure to biota and human populations.

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Oxidative damage induced by copper and beta-cypermethrin in gill of the freshwater crayfish Procambarus clarkii

Cited by 65 publications

References 36 publications

Biomarkers for the toxicity of sublethal concentrations of triclosan to the early life stages of carps

Biomarkers for the toxicity of sublethal concentrations of triclosan to the early life stages of carps

The Change of Metallothionein and Oxidative Response in Gills of the Oreochromis niloticus after Exposure to Copper

Bioavailability of pollutants sets risk of exposure to biota and human population in reservoirs from Iguaçu River (Southern Brazil)

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