Oxidative damage of dust storm fine particles instillation on lungs, hearts and livers of rats

Meng, Ziqiang; Zhang, Quanxi

doi:10.1016/j.etap.2006.04.005

Cited by 37 publications

(26 citation statements)

References 22 publications

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“…Lipid peroxidation causes dysfunction in the cell membrane, decreased fluidity, and inactivation of receptors and enzymes and changes ion permeability [2]. Hatano [10] studied that Cu accumulation in fibrotic livers caused by chronic hepatitis C may contribute to hepatic injury.…”

Section: Introductionmentioning

confidence: 99%

“…Hepatitis can also be due to toxins (notably alcohol), other infections, or from autoimmune process [1]. Essential micronutrients are involved in many metabolic pathways in the liver, such as enzymatic functions, protein synthesis, oxidative damage, anti-oxidant defense, immunological competence, and interferon therapy response to virus genomes [2]. Reactive oxygen species (ROS) have also been implicated in a number of hepatic pathologies in exacerbating liver diseases [3].…”

Section: Introductionmentioning

confidence: 99%

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Determination of Copper and Iron in Biological Samples of Viral Hepatitis (A–E) Female Patients

Afridi

Kazi

et al. 2008

Biol Trace Elem Res

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There is accumulative evidence that the metabolism of iron and copper is altered in viral hepatic diseases, and these nutrients might have specific roles in their pathogenesis and progress. The aim of present study was to compare the level of copper (Cu) and iron (Fe) in biological samples (serum, urine, and scalp hair) of female patients suffering from different viral hepatitis (A, B, C, D, and E; n = 253) of age range 31-45 years. For comparative study, 95 healthy females of the same age group residing in the same city were selected. The elements in the biological samples were analyzed by flame atomic absorption spectrophotometry, prior to microwave-assisted acid digestion. The validity and accuracy of the methodology was checked by using certified reference materials (CRMs) and with those values obtained by conventional wet acid digestion method on same CRMs. The results of this study showed that the mean values of Cu and Fe were higher in sera and scalp hair samples of hepatitis patients than age-matched control subjects, while the difference was significant (p < 0.001), in the cases of viral hepatitis B and viral hepatitis C as compared to viral hepatitis A, D, and E. The urinary levels of these elements were found higher in the hepatitis patients than in the age-matched healthy controls (p < 0.05). These results are consistent with literature-reported data, confirming that hepatic iron and copper overload can directly cause lipid peroxidation and eventually hepatic damage.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Determination of Copper and Iron in Biological Samples of Viral Hepatitis (A–E) Female Patients

Afridi

Kazi

et al. 2008

Biol Trace Elem Res

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“…Dust and dust storms have a considerable effect on visibility [1], air quality [2], human health [3] and the climate system [4]. Even though these dust storm effects had been broadly studied, the processes at the sources such as the frequency, duration, intensity or aerosol number-size distribution had not been adequately described.…”

Section: Introductionmentioning

confidence: 99%

Monitoring Dust Concentrations over Desert and Cropland during Dust Storms Using Visibility Sensors

Yonemura

Shen

et al. 2018

IOP Conf. Ser.: Earth Environ. Sci.

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Abstract. Directly measuring the dust concentration during a dust storm is very important for studying dust emission and wind erosion processes. The Mira visibility sensors were introduced for directly measuring dust concentrations over desert and cropland during dust storm events. The output of the sensor was compared with that of optical particle counter. We found that the Mira visibility sensors can directly measure the particle numbers concentrations. Characteristics of dust concentrations at the two ground surfaces during dust storms were analyzed. By using the Mira visibility sensors and optical particle counters and other meteorological elements in Dunhuang, China, dust emission processes and characteristics over desert and oasis during dust storms was discussed.

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“…Exposure to high levels of Cu results in various changes in the liver tissues that are consistent with oxidative damage to membranes and molecules. Lipid peroxidation causes dysfunction in the cell membrane, decreased fluidity, inactivation of enzymes and changes ion permeability [10,11]. Hatano studied that Cu accumulation in fibrotic livers caused by chronic hepatitis C may contribute to hepatic injury [12].…”

Section: Introductionmentioning

confidence: 99%

Estimate the Levels of Copper in Serum Samples of Hepatitis C Patients at Different Stages after Interferon-α Therapy

Ia¹,

GK²

2016

Pharm Anal Acta

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In this study, we evaluated the copper (Cu) levels in serum samples of patients infected by hepatitis C virus (HCV) at different stages and examined the changes in its content before and after interferon α (IFN-α) therapy with related to healthy subjects. The 199 HCV patients of both genders at different stages including (acute, fibrosis and cirrhosis) were enrolled in this study, who have completed IFN-α treatment and were followed for at least 1 year after the end the therapy. We have also evaluated the changes in biochemical parameters before and after treatment. Blood samples were collected from patients before and after treatment of IFN-α therapy. For comparative purposes healthy subjects of same age group (30-50) were also selected. The trace level of Cu in serum samples was determined by flame atomic absorption spectrometry after preconcentration by dual-cloud point extraction method. It was observed that after INF-α treatment the level of Cu in serum samples of HCV patients were reduced in decreasing order such as acute> fibrosis> cirrhosis.

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Oxidative damage of dust storm fine particles instillation on lungs, hearts and livers of rats

Cited by 37 publications

References 22 publications

Determination of Copper and Iron in Biological Samples of Viral Hepatitis (A–E) Female Patients

Determination of Copper and Iron in Biological Samples of Viral Hepatitis (A–E) Female Patients

Monitoring Dust Concentrations over Desert and Cropland during Dust Storms Using Visibility Sensors

Estimate the Levels of Copper in Serum Samples of Hepatitis C Patients at Different Stages after Interferon-α Therapy

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