2014
DOI: 10.1155/2014/302528
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Oxidative Damage to Nucleic Acids and Benzo(a)pyrene-7,8-diol-9,10-epoxide-DNA Adducts and Chromosomal Aberration in Children with Psoriasis Repeatedly Exposed to Crude Coal Tar Ointment and UV Radiation

Abstract: The paper presents a prospective cohort study. Observed group was formed of children with plaque psoriasis (n=19) treated by Goeckerman therapy (GT). The study describes adverse (side) effects associated with application of GT (combined exposure of 3% crude coal tar ointment and UV radiation). After GT we found significantly increased markers of oxidative stress (8-hydroxy-2′-deoxyguanosine, 8-hydroxyguanosine, and 8-hydroxyguanine), significantly increased levels of benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE)… Show more

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Cited by 22 publications
(30 citation statements)
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“…Monitored groups consisted of patients (men, women, and children) suffering from psoriasis treated by GT. In the groups of children, we found high degree of dermal absorption of PAHs (elevated levels of urinary 1-hydroxypyrene and hydroxylated phenanthrenes), elevated urinary mutagenicity (Ames test), and increased genotoxicity (chromosomal aberration in peripheral lymphocytes) (8,10,11). In addition, we found an elevated level of cellular stress (heat shock proteins; Hsp70) (11), oxidative stress (8-hydroxy-2′-deoxyguanosine, 8-hydroxyguanosine and 8-hydroxyguanine), and BPDE-DNA adducts (8).…”
Section: Discussionmentioning
confidence: 83%
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“…Monitored groups consisted of patients (men, women, and children) suffering from psoriasis treated by GT. In the groups of children, we found high degree of dermal absorption of PAHs (elevated levels of urinary 1-hydroxypyrene and hydroxylated phenanthrenes), elevated urinary mutagenicity (Ames test), and increased genotoxicity (chromosomal aberration in peripheral lymphocytes) (8,10,11). In addition, we found an elevated level of cellular stress (heat shock proteins; Hsp70) (11), oxidative stress (8-hydroxy-2′-deoxyguanosine, 8-hydroxyguanosine and 8-hydroxyguanine), and BPDE-DNA adducts (8).…”
Section: Discussionmentioning
confidence: 83%
“…Basic characteristics of the study group were described in our previous work (8). Briefly, the group was formed of children with chronic stable plaque psoriasis, treated by GT at the Clinic of Dermal and Venereal Diseases, University Hospital, Hradec Králové (Czech Republic).…”
Section: Study Groupmentioning
confidence: 99%
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