“…Metabolic drift and broad scale decreases in aerobic glycolysis, the tricarboxylic acid cycle, and oxidative phosphorylation are a common feature of brain aging ( Pandya et al, 2015 , 2016 ; Ivanisevic et al, 2016 ; Pollard et al, 2016 ; Goyal et al, 2017 ; Mattson and Arumugam, 2018 ; Watts et al, 2018 ; Guo et al, 2020 ). Metabolic impairments are associated with dysfunctional mitochondria and increasing levels of reactive oxygen species (ROS), which damage proteins and membranes ( Di Domenico et al, 2010 ; Paradies et al, 2011 ; Diot et al, 2016 ; Islam, 2017 ).…”