Oxidative degradation of the piscicide squoxin in aerated river water

Synthesis of 1,1′ [11C]‐methylene‐di‐(2‐naphthol) ([11C]ST1859) for PET studies in humans

“…Reaction times longer than 8 min were considered unpractical due to the short physical half-life of 11 C. We also tried the use of alkaline (i.e. aqueous potassium hydroxide) reaction conditions 3 as an alternative to the acidic conditions, which also failed to give improved yields.…”

“…14 C]ST1859, 3,4 we therefore planned to synthesize [ 11 C]ST1859 by reacting 2-naphthol with [ 11 C]formaldehyde ( Figure 1). [ 11 C]formaldehyde, which has been used as an intermediate in the synthesis of diverse carbon-11-labelled PET tracers, has previously been prepared using different methods, such as catalytic oxidation [5][6][7] or enzymatic conversion of [ 11 C]methanol.…”

Simplified synthesis of 1,1′[14C]‐methylene‐di (2‐naphthol). A radiochemical and kinetic approach

“…17 Its synthesis is reported in literature [17][18][19] but, despite the high production yields, the experimental procedures are characterized by drastic conditions (long reaction time and high temperature) which do not match our synthetic requirements. Oliver et al 20 have also prepared 1,1 0 -methylene-di-(2-naphthol) labeled with 14 C at C-8 of both aromatic rings and, in a different synthesis, at the methylene carbon, starting from 2-[8-…”