Oxidative DNA Damage in Prostate Cancer Patients Consuming Tomato Sauce-Based Entrees as a Whole-Food Intervention

Chen, Longwen; Stacewicz‐Sapuntzakis, Maria; Duncan, Claudine; Sharifi, Roohollah; Ghosh, Luna; Breemen, Richard B. van; Ashton, David; Bowen, Phyllis E.

doi:10.1093/jnci/93.24.1872

Cited by 372 publications

(219 citation statements)

References 29 publications

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“…26,27 Subsequent analysis provided in vivo evidence that these effects related to tomato sauce consumption may be a result of an increase in apoptotic cell death. 28 Furthermore, men with metastatic CaP have been shown, in a randomized study, to have an improved outcome on many fronts, including diseasespecific mortality, when treated with androgen deprivation by orchidectomy with the addition of lycopene supplementation (2 mg b.d.)…”

Section: Discussionmentioning

confidence: 99%

Lycopene inhibits DNA synthesis in primary prostate epithelial cells in vitro and its administration is associated with a reduced prostate-specific antigen velocity in a phase II clinical study

Barber

Zhang

Zhu

et al. 2006

Prostate Cancer Prostatic Dis

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Interest in lycopene has focused primarily on its use in the chemoprevention of prostate cancer (CaP); there are few clinical trials involving men with established disease. In addition, most data examining its mechanism of action have been obtained from experiments using immortal cell lines. We report the inhibitory effect(s) of lycopene in primary prostate epithelial cell (PEC) cultures, and the results of a pilot phase II clinical study investigating whole-tomato lycopene supplementation on the behavior of established CaP, demonstrating a significant and maintained effect on prostatespecific antigen velocity over 1 year. These data reinforce the justification for a large, randomized, placebo-controlled study.

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Section: Discussionmentioning

confidence: 99%

Lycopene inhibits DNA synthesis in primary prostate epithelial cells in vitro and its administration is associated with a reduced prostate-specific antigen velocity in a phase II clinical study

Barber

Zhang

Zhu

et al. 2006

Prostate Cancer Prostatic Dis

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“…As patients with type II diabetes are at an increased risk of developing coronary heart disease, and oxidized LDLs have been shown to contribute to this risk of arterial disease (Libby, 2006), tomato product supplementation maybe of potential benefit in these patients. Tomato lycopene consumption in patients before prostatectomy has been reported in few studies to lower prostate DNA oxidative damage, serum prostate-specific antigen, and cause an overall reduction in disease aggressiveness (Chen et al, 2001;Kucuk et al, 2001Kucuk et al, , 2002Bowen et al, 2002; Table 1). Tomato product or purified lycopene supplementation has previously been shown to decrease oxidative damage in cellular DNA in healthy volunteers (Riso et al, 1999(Riso et al, , 2004Porrini and Riso, 2000;Porrini et al, 2002Porrini et al, , 2005Zhao et al, 2006; Table 1).…”

Section: Mechanisms Of Action Of Lycopenementioning

confidence: 99%

Tomatoes versus lycopene in oxidative stress and carcinogenesis: conclusions from clinical trials

2006

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Objective: To review the effects of tomato product supplementation, containing lycopene, on biomarkers of oxidative stress and carcinogenesis in human clinical trials. Results: Supplementation of tomato products, containing lycopene, has been shown to lower biomarkers of oxidative stress and carcinogenesis in healthy and type II diabetic patients, and prostate cancer patients, respectively. Processed tomato products like tomato juice, tomato paste, tomato puree, tomato ketchup and tomato oleoresin have been shown to provide bioavailable sources of lycopene, with consequent increases in plasma lycopene levels versus baseline. Dietary fats enhance this process and should be consumed together with food sources of lycopene. The mechanisms of action involve protection of plasma lipoproteins, lymphocyte DNA and serum proteins against oxidative damage, and anticarcinogenic effects, including reduction of prostate-specific antigen, upregulation of connexin expression and overall decrease in prostate tumor aggressiveness. There is limited in vivo data on the health benefits of lycopene alone. Most of the clinical trials with tomato products suggest a synergistic action of lycopene with other nutrients, in lowering biomarkers of oxidative stress and carcinogenesis. Conclusions: Consumption of processed tomato products, containing lycopene, is of significant health benefit and can be attributed to a combination of naturally occurring nutrients in tomatoes. Lycopene, the main tomato carotenoid, contributes to this effect, but its role per se remains to be investigated.

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“…Fruits are also functional foods that are a source of nutraceuticals. It is through antioxidizing capacity along with anti-carcinogenic and antimutagenic activities that the pigments and other phytochemicals present in the fruit exhibit their protective effects against chronic disease states, different types of cancers, macular and cardiac vascular diseases and other age-related problems (Rao and Agarwal 1998;Chen et al 2001;Powell and Bennett 2002;Giovannucci 2002;Mares-Perlman et al 2002). These health benefits emphasise the need and importance of fruits in our daily diet.…”

Section: Introductionmentioning

confidence: 99%

Role of internal atmosphere on fruit ripening and storability—a review

2011

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Concentrations of different gases and volatiles present or produced inside a fruit are determined by the permeability of the fruit tissue to these compounds. Primarily, surface morphology and anatomical features of a given fruit determine the degree of permeance across the fruit. Species and varietal variability in surface characteristics and anatomical features therefore influence not only the diffusibility of gases and volatiles across the fruits but also the activity and response of various metabolic and physiological reactions/processes regulated by these compounds. Besides the well-known role of ethylene, gases and volatiles; O 2 , CO 2 , ethanol, acetaldehyde, water vapours, methyl salicylate, methyl jasmonate and nitric oxide (NO) have the potential to regulate the process of ripening individually and also in various interactive ways. Differences in the prevailing internal atmosphere of the fruits may therefore be considered as one of the causes behind the existing varietal variability of fruits in terms of rate of ripening, qualitative changes, firmness, shelf-life, ideal storage requirement, extent of tolerance towards reduced O 2 and/or elevated CO 2 , transpirational loss and susceptibility to various physiological disorders. In this way, internal atmosphere of a fruit (in terms of different gases and volatiles) plays a critical regulatory role in the process of fruit ripening. So, better and holistic understanding of this internal atmosphere along with its exact regulatory role on various aspects of fruit ripening will facilitate the development of more meaningful, refined and effective approaches in postharvest management of fruits. Its applicability, specially for the climacteric fruits, at various stages of the supply chain from growers to consumers would assist in reducing postharvest losses not only in quantity but also in quality.

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Oxidative DNA Damage in Prostate Cancer Patients Consuming Tomato Sauce-Based Entrees as a Whole-Food Intervention

Abstract: These data indicate a possible role for a tomato sauce constituent, possibly lycopene, in the treatment of prostate cancer and warrant further testing with a larger sample of patients, including a control group.

Cited by 372 publications

References 29 publications

Lycopene inhibits DNA synthesis in primary prostate epithelial cells in vitro and its administration is associated with a reduced prostate-specific antigen velocity in a phase II clinical study

Lycopene inhibits DNA synthesis in primary prostate epithelial cells in vitro and its administration is associated with a reduced prostate-specific antigen velocity in a phase II clinical study

Tomatoes versus lycopene in oxidative stress and carcinogenesis: conclusions from clinical trials

Role of internal atmosphere on fruit ripening and storability—a review

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