Oxidative DNA Damage to Sperm Cells and Peripheral Blood Leukocytes in Infertile Men

Taken, Kerem; Hakan, Hamit; Eryılmaz, Recep; Dönmez, Muhammet İrfan; Demir, Murat; Güneş, Mustafa; Aslan, Rahmi; Şekeroğlu, Mehmet Ramazan

doi:10.12659/msm.898631

Cited by 22 publications

(17 citation statements)

References 32 publications

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“…Oxidative damage to lipids results in lipid peroxidation, and malondialdehyde (MDA) is one of the by-products of lipid peroxidation, which has been used in various biochemical assays to monitor the degree of peroxidative damage sustained by spermatozoa [ 88 ]. There were 28 articles including 1412 infertile patients and 871 fertile controls that were used to perform the meta-analysis of seminal plasma MDA concentration [ 13 , 26 , 27 , 29 , 30 , 33 – 35 , 39 , 40 , 43 , 45 – 47 , 51 – 58 , 60 , 62 , 65 , 66 , 71 , 72 ]. The statistical heterogeneity was notable ( I 2 = 95%), so the random-effect model was chosen to calculate the integrated effect, showing that the seminal plasma MDA concentrations in infertile patients were higher than those in control groups (SMD = 1.86, 95% CI: 1.40, 2.33, Z = 7.85, p < 0.00001; Figure 2 ).…”

Section: Resultsmentioning

confidence: 99%

“…Excessive NO could cause sperm hypomotility and reduce fertility in humans [ 95 ]. Six studies were included in the meta-analysis to evaluate the NO concentration in seminal plasma, containing 326 infertile patients and 222 fertile controls [ 33 , 37 , 44 , 54 , 64 , 69 ]. The heterogeneity was notable (I 2 = 87%), so the integrated effect was calculated from a random-effect model.…”

Section: Resultsmentioning

confidence: 99%

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Is male infertility associated with increased oxidative stress in seminal plasma? A-meta analysis

et al. 2018

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ObjectivesWe conducted a systematic review and meta-analysis of observational case-control studies to evaluate markers of oxidative stress in seminal plasma of patients with male infertility.BackgroundCurrent evidence links oxidative stress to male infertility, in which multiple markers of oxidative stress have been widely detected, publishing inconsistent results with regard to the role of oxidative stress markers in the evaluation of male infertility. Therefore, a systematic review and meta-analysis on this issue is necessary.ResultsFrom the 1024 articles initially retrieved, 65 studies were included in our meta-analysis with 11 oxidative stress markers, containing 3819 male infertility patients and 2012 controls. The concentrations of malondialdehyde (SMD = 1.86, p < 0.00001), NO (SMD = 0.89, p = 0.001), carbonyl protein (SMD = 2.09, p < 0.00001) in seminal plasma were significantly higher in infertility patients. The concentrations of GSH (SMD = –1.68, p < 0.00001), vitamin C (SMD = –1.12, p < 0.00001), and vitamin E (SMD = –1.48, p = 0.003), as well as the activities of catalase (SMD = –1.91, p < 0.0001), glutathione peroxidase (SMD = –1.96, p = 0.0002) and glutathione-S-transferase (SMD = –1.62, p = 0.009) declined remarkably, resulting in decreased total antioxidant capacity (SMD = –1.77, p < 0.00001). Besides, the activity of superoxide dismutase showed no statistical difference between infertility patients and controls (SMD = –0.51, p = 0.07).ConclusionsOur meta-analysis suggests that oxidative stress in seminal plasma resulting from decreased antioxidant defense are associated with male infertility.MethodsUsing PubMed, EMBASE, CNKI, VIP, and Wanfang database, we searched for literature reporting the detection of oxidative stress markers in the seminal plasma of male infertility published up to June 2017. Standardized mean differences (SMDs) and 95% confidence intervals (95%CI) were calculated for the finally analysis.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Is male infertility associated with increased oxidative stress in seminal plasma? A-meta analysis

et al. 2018

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“…These findings agree with Delfino et al (2007) [8] that reported significantly lower results of the percent of normal sperm morphology and motility in diabetic patients compared to the non-diabetic group. Considering the morphology of sperms, it is a fact that the sperm cells being rapidly proliferating cells can be an easy target of damage by this oxidative stress caused by diabetes and abnormal sperm shape [14]. In fact, sperm morphology is probably the most difficult part of semen analysis to perform, and it is not easy to interpret, but the authors of this study confirmed that the part was well done according to WHO criteria, so it is suggested to conduct other studies in Sudanese with larger sample size that might be more helpful to confirm this difference.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Semen Quality in Type 2 Diabetes Mellitus Sudanese Patients Compared to Non-Diabetic Subjects

Ibrahim¹,

Rida²,

Abdrabo³

2018

TOCCHEMJ

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Background: Diabetes leads to metabolic abnormalities. These abnormalities produce problems in a variety of organ systems such as ophthalmopathies, neuropathies, nephropathies, and vasculopathies. Infertility is common in diabetic patients, caused by abnormal semen. Objectives: This study was conducted to check semen quality in diabetic Sudanese patients. Method: This is a retrospective cross-sectional designed study. The data were collected in a period from January 2015 to February 2017. A total of 600 individuals was included, 300 with type 2 diabetes mellitus and 300 apparently healthy as a non-diabetic. Semen analysis was performed according to WHO criteria. Results: Significant lower results were found in diabetic patients compared to non diabetic regarding the following parameters: volume of ejaculation (p = 0.047), percent motility (p = 0.001), percent normal morphology (p = 0.000), while there was no difference in the sperm count between diabetic and non-diabetic subjects. Conclusion: Semen of types 2 diabetes mellitus patients is of low volume, abnormal motility and morphology compared to non-diabetic subjects.

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“…Researchers observed that similar to seminal plasma antioxidants, blood antioxidants also associated with semen quality in infertile men as compared with fertile (healthy) controls [24] . These findings suggest that blood antioxidants could be a valuable diagnostic tool for evaluating sperm quality potential [26] . Therefore, this study mainly focused on blood antioxidants since their correlation with sperm quality has been less emphasized.…”

Section: Research Papermentioning

confidence: 76%

Impact of Smoking and Alcohol Consumption on Oxidative Status in Male Infertility and Sperm Quality

Ramgir¹,

Abilash²

2019

ijps

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Ramgir and Abilash: Smoking and Alcohol in Male Infertility The most common unhealthy lifestyle factors like cigarette smoking and drinking alcohol have controversial reports on how these impact male fertility. The present study assessed the potential effects of these habits on sperm quality, male reproductive hormones, and blood plasma oxidative profile in 133 infertile men with 124 fertile, healthy controls. Among the participants, 28 (10.8 %), 29 (11.2 %), 33 (12.8 %), 34 (13.2 %) fertile men were non-alcoholics and non-smokers (total abstainers), smokers, alcohol drinkers, and smokers plus alcohol drinkers, respectively. On the other hand, 32 (12.4 %), 30 (11.6 %), 34 (13.2 %), 37 (14.3 %) infertile men were total abstainers, smokers, alcohol drinkers, and smokers plus alcohol drinkers, respectively. The conventional sperm parameters and reproductive hormone levels were found to be significantly different in the subsets of infertile men than those of fertile men (p<0.001). In these subsets of infertile men, blood plasma malondialdehyde, nitric oxide concentrations were significantly higher and superoxide dismutase, reduced glutathione activities were significantly lower when compared to fertile men and infertile men total abstainers group (p<0.001). In infertile subjects, particularly smoking-alcohol drinking group was more affected than only smoking or alcohol drinking groups. Furthermore, these oxidative markers were correlated with sperm concentration, motility, and morphology, except nitric oxide concentration, which was only associated with sperm motility. These findings highlighted that blood plasma antioxidants are as efficient as seminal plasma antioxidants in male fertility evaluation.

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Oxidative DNA Damage to Sperm Cells and Peripheral Blood Leukocytes in Infertile Men

Cited by 22 publications

References 32 publications

Is male infertility associated with increased oxidative stress in seminal plasma? A-meta analysis

Is male infertility associated with increased oxidative stress in seminal plasma? A-meta analysis

Evaluation of Semen Quality in Type 2 Diabetes Mellitus Sudanese Patients Compared to Non-Diabetic Subjects

Impact of Smoking and Alcohol Consumption on Oxidative Status in Male Infertility and Sperm Quality

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