Oxidative markers in children with severe obesity following low‐calorie diets supplemented with mandarin juice

Abstract

The mandarin juice consumption with a reduced calorie diet positively affects the antioxidant defence and produces a decrease in biomarkers of oxidative stress in obese children.

Glutathione s-transferase p in glucose homeostasis in mice.

“…Consistent with the view that ROS-mediated injury can be attributed in part to lipid-derived aldehydes, almost 7% of AFABP in adipose tissue was covalently modified by 4-HNE in obese insulin-resistant C57Bl/6J mice, resulting in a decreased binding affinity for fatty acids [30]. Increased plasma protein carbonyls, as a biomarker of systemic oxidative stress, was positively correlated with IR in obese patients [31] and was significantly decreased following treatment [32,33]. As a result of these (and many more) findings, there has been a surge in interest in evaluating how aldehyde metabolism and protein carbonylation may serve as a mechanistic link between oxidative stress and IR.…”

Vitamin C in the Treatment and/or Prevention of Obesity

“…For example, when children with severe obesity consumed a low-calorie diet with mandarin juice, they experienced a significant decrease in malondialdehyde and carbonyl groups levels in plasma, together with an increase in blood antioxidants such as VC (69). Furthermore, it has been observed that a vitamin E (VE)/VC supplementation induces a reduction of both high sensitive C-reactive protein plasma levels and cobalt-albumin binding score as measures of oxidative stress, indicating anti-atherogenic effects in humans (70).…”

“…Lower intracellular and extracellular ROS content following VC treatment in isolated adipocytes from lean rats (33) Mandarin juice (VC rich), jointly with low-calorie diet consumption, induced significant decrease in MDA and carbonyl group in plasma, and an increase in VC plasma levels, in children with severe obesity (69) Combined VE/VC supplementation induced lower hsCRP and cobalt-albumin binding in humans (70) An antioxidant supplementation (including VC) improved oxidative stress markers in obese children and adolescents (71) Lower lipid peroxidation (measured as F2-isoprostane levels) in humans after VE/VC supplementation. F2-isoprostane was strongly correlated with obesity (72) Improvement in impaired acetylcholine-stimulated vasodilatation in obese subjects following VC infusion (67) An antioxidant supplementation (VE, VC and carotene) prevented rise in oxidative stress induced by lower exercise in young overweight adults (73) Increase in plasma vitamin C levels correlated with decline in plasma free radicals and increase in GSH levels following chronic VC administration (63) Adipocyte differentiation and lipolysis VC treatment stimulated spontaneous 3T3-L1 mouse pre-adipocyte differentiation (74,76) Evidence Detail Reference…”

Impact of anti-inflammatory nutrients on obesity-associated metabolic-inflammation from childhood through to adulthood

“…However, this did not translate into an adult cohort, where supplementation with epigallocatechin gallate did not alter features of the MetS or biomarkers of inflammation such as IL-6, IL-1β and CRP, but did significantly reduce serum amyloid A (101) . In two separate cohorts of overweight and obese adolescents, treatment with an antioxidant supplement influenced anti-oxidant defence and oxidative stress positively, with no improvement in inflammatory markers observed (102,103) .…”