Oxidative metabolism of mescaline in the central nervous system—III

Seiler, Nikolaus; Demisch, L.

doi:10.1016/0006-2952(74)90417-1

Cited by 13 publications

(3 citation statements)

References 37 publications

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“…TMPA is demethylated to form the substance 3,4-dihydroxy-5-methoxyphenylacetic acid, which is finally linked to glutamine by the glutamine N-acyltransferase to be excreted as 3,4-dihydroxy-5-methoxyphenacetylglutamine [45]. In vivo studies on mouse livers and brains have shown that conversion of TMPA to 3,4,5-trimethoxybenzoic acid (3,4,5-TMBA) is also possible [47]. In the brain, detoxification of mescaline is assumed to occur mainly through N-acetylation [47].…”

Section: Mescaline-metabolism Clinical Reactions and Signallingmentioning

confidence: 99%

“…In vivo studies on mouse livers and brains have shown that conversion of TMPA to 3,4,5-trimethoxybenzoic acid (3,4,5-TMBA) is also possible [47]. In the brain, detoxification of mescaline is assumed to occur mainly through N-acetylation [47]. Studies in mice and rats confirm the formation of N-acetylmescaline, its O-demethylated metabolites N-acetyl-3,5-dimethoxy-4-hydroxy-phenylethylamine and N-acetyl-3,4-dimethoxy-5-hydroxy-phenylethylamine [48].…”

Section: Mescaline-metabolism Clinical Reactions and Signallingmentioning

confidence: 99%

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An Overview on the Hallucinogenic Peyote and Its Alkaloid Mescaline: The Importance of Context, Ceremony and Culture

Doesburg-van Kleffens,

Zimmermann-Klemd,

Gründemann

2023

Molecules

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Peyote (Lophophora williamsii) is a cactus that contains various biologically active alkaloids—such as pellotine, anhalonidine, hordenine and mescaline. Here, mescaline induces the psychoactive effects of peyote through the activation of the serotonin 5-HT2A receptor and the subsequent release of calcium (Ca2+) from the endoplasmic reticulum (ER). Moreover, an evaluation of the therapeutic benefits of mescaline is also currently the subject of research. It is important to consider that the outcome of taking a psychedelic drug strongly depends on the mindset of the recipient and the context (set and setting principle), including ceremonies and culture. This overview serves to summarise the current state of the knowledge of the metabolism, mechanism of action and clinical application studies of peyote and mescaline. Furthermore, the benefits of the potential of peyote and mescaline are presented in a new light, setting an example for combining a form of treatment embedded in nature and ritually enriched with our current highly innovative Western medicine.

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Section: Mescaline-metabolism Clinical Reactions and Signallingmentioning

confidence: 99%

Section: Mescaline-metabolism Clinical Reactions and Signallingmentioning

confidence: 99%

An Overview on the Hallucinogenic Peyote and Its Alkaloid Mescaline: The Importance of Context, Ceremony and Culture

Doesburg-van Kleffens,

Zimmermann-Klemd,

Gründemann

2023

Molecules

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“…Diese Verbindungen unterliegen vor oder nach 0-Methylierung einer oxidativen Desaminierung zum Aldehyd, der entweder zum Glycol reduziert, hauptsachlich aber zu Mandelsauren oxidiert wird. Zusatzlich sind auch die entsprechenden Benzoesauren als Katabolite beschrieben worden (DIRSCHERL et al, 1962;GOODALL und 'ALTON, 1969;SEILER und DEMISCH, 1974;CHAPMAN und MAR-CROFT, 1973). Aus Tieren, bzw.…”

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Stoffwechsel Und Abbau Von Phenyläthylaminen in Pflanzlichen Zellsuspensionskulturen

Meyer¹,

Barz²

1975

Planta Med

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T o investigate the catabolic pathways o f pheriylethylamine alcaloids in plant cell suspension cultures preliminary experiments with (2-14C)-tyramine and (2-14C)-dopamine were performed. In numerous cell suspension-cultures formation o f 14C02 from both substrates ranging from 0,5-1,2% (tyramine) to 0,8-2,7% (dopamine) could be observed. As main metabolites of tyramine p-hydroxyphenylacetic acid and p-hydroxybenzoic acid could be identified whereas evidence for the formation of 3,4-dihydroxyphenylacetic acid from tyramine could also be obtained.

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Drug Metabolism: Review of Principles and the Fate of One-Ring Psychotomimetics

Castagnoli

1978

Stimulants

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Oxidative metabolism of mescaline in the central nervous system—III

Cited by 13 publications

References 37 publications

An Overview on the Hallucinogenic Peyote and Its Alkaloid Mescaline: The Importance of Context, Ceremony and Culture

An Overview on the Hallucinogenic Peyote and Its Alkaloid Mescaline: The Importance of Context, Ceremony and Culture

Stoffwechsel Und Abbau Von Phenyläthylaminen in Pflanzlichen Zellsuspensionskulturen

Drug Metabolism: Review of Principles and the Fate of One-Ring Psychotomimetics

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