Oxidative status shifts in uterine cervical incompetence patients

Zolotukhin, Peter; Александрова, А. А.; Goncharova, Anna S.; Шестопалов, А. В.; Rymashevskiy, A.N.; Шкурат, Т. П.

doi:10.3109/19396368.2013.864343

Cited by 5 publications

(4 citation statements)

References 38 publications

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“…The underlying mechanisms leading to spontaneous preterm labour are not fully understood. Evidence for oxidative stress in women with cervical incompetence is inconsistent, 40 and this may reflect the heterogeneous nature of this population. Another study has reported significantly decreased serum selenium concentrations in women who went on to deliver preterm compared to controls.…”

Section: Preterm Labour and Preterm Pre-labour Rupture Of Membranesmentioning

confidence: 99%

Oxidative stress in pregnancy and reproduction

2016

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Oxidative stress is implicated in the pathophysiology of many reproductive complications including infertility, miscarriage, pre-eclampsia, fetal growth restriction and preterm labour. The presence of excess reactive oxygen species can lead to cellular damage of deoxyribonucleic acids, lipids and proteins. Antioxidants protect cells from peroxidation reactions, limiting cellular damage and helping to maintain cellular membrane integrity. There is overwhelming evidence for oxidative stress causing harm in reproduction. However, there is sparse evidence that supplementation with commonly used antioxidants (mostly vitamins C and E) makes any difference in overcoming oxidative stress or reversing disease processes. There may be potential for antioxidant therapy to ameliorate or prevent disease, but this requires a thorough understanding of the mechanism of action and specificity of currently used antioxidants.

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Section: Preterm Labour and Preterm Pre-labour Rupture Of Membranesmentioning

confidence: 99%

Oxidative stress in pregnancy and reproduction

2016

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“…Clinical and experimental evidence suggests that uric acid plays a major role in the human body as an antioxidant and OS marker (38). Studies on the etiopathogenesis of abortion have not yet measured serum uric acid level as a biomarker of OS; however, the marker has been measured in some pregnancy complications such as cervical insufficiency (39) and preeclampsia (40).…”

Section: Discussionmentioning

confidence: 99%

Oxidative Stress Markers in Early Pregnancy Loss: A Case-Control Study

Torkzahrani

Ataei

Hedayati

et al. 2018

International Journal of Women’s Health and Reproduction Scienc

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Objectives: Evidence suggests that oxidative stress (OS) plays a prominent role in the pathophysiology of pregnancy complications in women. The present study was conducted to determine the levels of OS markers in early pregnancy loss and to compare the results with those in healthy pregnant women. Materials and Methods: A total of 32 women with early pregnancy loss and 32 healthy women in the first trimester of pregnancy, with similar demographic characteristics entered this study as the cases and controls. Serum levels of malondialdehyde (MDA), total antioxidant capacity (TAC), uric acid, and bilirubin levels were determined in both groups. The data obtained were then analyzed and compared between the groups using the independent samples t test and Mann-Whitney U test. Results: The 2 groups matched in terms of personal-demographic characteristics including mother’s age, father’s age, gravidity, and body mass index (BMI). MDA levels increased significantly in the women with spontaneous abortion compared to the healthy pregnant women (4.35±1.47 vs. 3.42±1.68 µM/L; P=0.026) and TAC decreased significantly in the cases compared to the healthy controls (552.34±212.79 vs. 1003.23±1168.68 U/mL; P=0.040). Uric acid and bilirubin levels did not differ between the groups. Conclusions: The results of this study provides further evidence on the effect of increased OS on the incidence of early spontaneous abortion in the first trimester of pregnancy. High serum MDA levels and low TAC during pregnancy were 2 risk factors for spontaneous abortion. The present findings support the hypothesis that OS plays a key role in the etiopathogenesis of spontaneous abortion. Further studies are required for assessing the preventive role of antioxidant therapy in this complication.

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“…Our lab developed an NFE2L2/ AP-1 pathway-based systemic biomarker for assessing slight changes in physiological parameters of the human organism using peripheral blood leukocytes as the preferred sample type [66]. The same systemic approach utilizing another set of oxidative status markers was successfully used for unveiling features of uterine cervical incompetence patients [67]. Other labs also successfully apply pathway activation-based technologies in various field and other sample types, with special attention paid to fresh solid tumors samples and paraffin blocks [68].…”

Section: Current Advances In Developing Systemic Biomarkersmentioning

confidence: 99%

Oxidative Status Pathways: Systemic Biomarkers

Zolotukhin¹,

Chmykhalo²,

Belanova³

et al. 2018

Biomarker - Indicator of Abnormal Physiological Process

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Systemic biomarkers (i.e. biomarkers of functioning of cellular pathways) offer a broad spectrum of diagnostic capabilities. There are several approaches to using systemic biomarkers that derive from exact needs of a researcher or a clinical specialist. First, analyzing a multifunctional and multi-systemic pathway in circulating cells (e.g. leukocytes) allows to gather generalized information on functioning of the organism. Second, there are numerous pathways that, even still in circulating cells, allow to assess risks of developing or stage of development of numerous diseases, including the leaders of non-infection diseases mortality-cardiovascular diseases. Third, biopsy specimens can readily be used to assess the exact signaling type of a disease (especially cancer) thus helping in selecting the best treatment option. Due to unique properties of the human oxidative status pathways that are discussed in the present chapter, diagnostics specialists are now acquiring an allin-one toolbox for profiling and detecting almost any non-infectious and a broad range of infectious diseases. In addition to properties of the human oxidative status pathways opening these possibilities, this chapter considers exact systemic biomarkers deriving from this approach, reveals some examples of usage of the resulting diagnostic technology and provides instances of successful clinical application of the systemic biomarker approach.

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Oxidative status shifts in uterine cervical incompetence patients

Cited by 5 publications

References 38 publications

Oxidative stress in pregnancy and reproduction

Oxidative stress in pregnancy and reproduction

Oxidative Stress Markers in Early Pregnancy Loss: A Case-Control Study

Oxidative Status Pathways: Systemic Biomarkers

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