Oxidative Stress: A Common Factor in Testicular Dysfunction

Turner, Terry T.; Lysiak, Jeffrey J.

doi:10.2164/jandrol.108.005132

Cited by 477 publications

(365 citation statements)

References 143 publications

(159 reference statements)

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“…Male germ cell membranes are sensitive to oxygen-induced damage mediated by lipid peroxidation due to their membranes are rich in polyunsaturated fatty acids [40,41]. Therefore, some antioxidants (e.g., vitamin C, vitamin E, glutathione, and coenzyme Q10) have been demonstrated to help treat male infertility [42][43][44].…”

Section: Discussionmentioning

confidence: 99%

Green tea extracts attenuate doxorubicin-induced spermatogenic disorders in conjunction with higher telomerase activity in mice

Sakai

Sueoka

Tanigaki

et al. 2010

J Assist Reprod Genet

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Purpose The aim of this study was to investigate the protective effect of green tea extracts against doxorubicininduced damage in the mouse testes correlating with telomerase activity. Methods Green tea extracts were administered orally. Doxorubicin was coadministered intraperitoneally. These testes were evaluated histologically and the telomerase activity was analyzed. Additional immunostaining was carried out. Results Both the sperm density and sperm motility were significantly increased in green tea extracts coadministration groups as compared to the doxorubicin-treated groups. By histological analysis, germ cell damage was greatly attenuated by green tea extracts coadministration. Telomerase activity significantly increased in association with the coadministration of green tea extracts as compared to that of doxorubicin-only groups. In all groups, human telomerase reverse transcriptase signals were mainly observed in the spermatocytes and spermatids.Conclusions These findings suggest that green tea extracts exert protective effects against doxorubicin-induced spermatogenic disorders in conjunction with higher telomerase activity levels.

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Section: Discussionmentioning

confidence: 99%

Green tea extracts attenuate doxorubicin-induced spermatogenic disorders in conjunction with higher telomerase activity in mice

Sakai

Sueoka

Tanigaki

et al. 2010

J Assist Reprod Genet

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“…Infections can lead to oxidative stress which can be evaluated by measuring reactive oxygen species (ROS) levels in seminal plasma. ROS levels show a significant, age-dependent increase in the aging male (Cocuzza et al, 2008) and may lead to DNA damage (Aitken and De Iuliis, 2007;Turner and Lysiak, 2008).…”

Section: Paternal Age and Infectionsmentioning

confidence: 99%

Paternal age and reproduction

Sartorius

Nieschlag

2009

Human Reproduction Update

291

212

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background: Due to various sociological factors, couples in developed countries are increasingly delaying childbearing. Besides ethical, economical and sociological issues, this trend presents us with several complex problems in reproduction. Although it is well-known that maternal age has a negative effect on fertility and increases the risk of adverse outcome during pregnancy and in offspring, the paternal influence on these outcomes is less well researched and not well-known.methods: We performed a systematic search of PubMed, and retrieved original articles and review articles to update our previous survey in this journal.results: This review highlights the link between male age and genetic abnormalities in the germ line and summarizes the knowledge about the effects of paternal age on reproductive function and outcome. Increasing paternal age can be associated with decreasing androgen levels, decreased sexual activity, alterations of testicular morphology and a deterioration of semen quality (volume, motility, morphology). Increased paternal age has an influence on DNA integrity of sperm, increases telomere length in spermatozoa and is suggested to have epigenetic effects. These changes may, at least in part, be responsible for the association of paternal age over 40 years with reduced fertility, an increase in pregnancy-associated complications and adverse outcome in the offspring. conclusion: Although higher maternal age can be an indication for intensive prenatal diagnosis, including invasive diagnostics, consideration of the available evidence suggests that paternal age itself, however, provides no rationale for invasive procedures.

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“…In this context, oxidative stress is increasingly recognized as a major causative factor in the aetiology of male infertility [15][16][17][18]. However, we have only just begun to understand the origins of such stress and the central role played by the mitochondria in the generation of reactive oxygen species by the male gamete [19].…”

Section: The Futurementioning

confidence: 99%

Whither must spermatozoa wander? The future of laboratory seminology

Aitken

2010

Asian J Androl

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This commentary celebrates the publication of the 5th edition of the World Health Organization Laboratory Manual for the Examination and Processing of Human Semen. This is the most complete text to date on the creation of a conventional semen profile and includes invaluable reference limits for specific aspects of semen quality based on the analysis of over 1 900 recent fathers. The new edition of the manual also includes detailed protocols for monitoring different aspects of sperm function and new chapters on the preparation of spermatozoa for assisted conception and cryopreservation. Given that this publication is the definitive statement on how to perform a descriptive semen analysis, we might speculate on the future of this field and the sorts of tests that might feature in future editions of the manual. Cell biologists are currently being empowered by the 'omics revolution, which is placing at their disposal technologies of unprecedented power to examine the biochemical composition of cells such as spermatozoa. Indeed, spermatozoa are perfect vehicles for this kind of analysis because they can be obtained as extremely pure suspensions, exist naturally in isolation and can be induced to express their capacity for fertilization and the initiation of embryonic development in vitro. The application of 'omics technologies to these cells, in concert with detailed assessments of their functional competence, should provide insights into the biochemical basis of defective semen quality. This information will then help us understand the causes of male infertility and to develop rational methods for its treatment and possible prevention. Keywords: assisted conception, DNA damage, male infertility, miscarriage, semen, seminology, spermatozoa 1 In the beginning A long long time ago, when in vitro fertilization (IVF) was in its first flush of youth and Intracytoplasmic sperm injection (ICSI) had not driven seminology into the reproductive wilderness, the development of robust methods for the diagnosis and treatment of male infertility was regarded as a noble cause worthy of engagement.In those far-off days, the descriptive semen profile was the only means we had of determining the fertility of men attending infertility clinics. This profile focused on an analysis of sperm number, motility and morphology underpinned by the fundamental belief that fertility is essentially a war of attrition. According to this model, the ejaculate must contain more than a certain critical number of motile, morphologically normal spermatozoa in order to withstand the cellular carnage that inevitably accompanies the perilous transition from the point of insemination to the site of fertilization. In diagnostic terms, the concept that male fertility is essentially 'a numbers game' resulted in a preoccupation with threshold counts for sperm number, motility and morphology that define the conventional semen profile, even to this day. The belief that fertility is entirely dependent on sperm number was, ironically,

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Oxidative Stress: A Common Factor in Testicular Dysfunction

Cited by 477 publications

References 143 publications

Green tea extracts attenuate doxorubicin-induced spermatogenic disorders in conjunction with higher telomerase activity in mice

Green tea extracts attenuate doxorubicin-induced spermatogenic disorders in conjunction with higher telomerase activity in mice

Paternal age and reproduction

Whither must spermatozoa wander? The future of laboratory seminology

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