Oxidative Stress and Anti-oxidative Defence in Patients with Age-related Macular Degeneration

Abstract

The results of the present study show that there is a significant increase in oxidative stress in AMD patients and significant decrease in antioxidant defence, in the total thiol level and in PON1 activity in AMD patients compared with controls. The increased oxidative stress and decreased antioxidant levels may have a synergistic role in AMD development.

A Novel Tool for the Assessment Oxidative Stress in Age-Related Macular Degeneration: Thiol/Disulfide Homeostasis Revisited

“…22 Previous studies indicated that total thiol levels were lower in patients with AMD compared to healthy subjects. 23,24 Similar to these studies, total thiol levels were lower in AMD patients in our study group compared to healthy subjects. However, in a recent study, Erel and Neselioglu 15 described that total thiol levels might remain in a plateau level despite the significant variability in plasma oxidant concentrations in the human metabolism.…”

Analysis of antioxidative factors related to AMD risk development in the polish patients

“…), TTS (total thiol status), PON1 (paraoxonase) and high‐level TOS (total oxidant status) (Uğurlu et al. ) and concentration of plasma malondialdehyde (MDA; Evereklioglu et al. ) were indicated.…”

Human plasma metabolomics in age-related macular degeneration (AMD) using nuclear magnetic resonance spectroscopy

“…[2],[3] Serologic biomarkers of AMD incidence and progression have been sought, primarily relating to pathways responsive to inflammation,[5–7] cell stress (particularly oxidative stress) or toxicity. [2],[7],[8] Such studies have, however, provided inconsistent results and, hence, clinical practice still solely relies on the evaluation of phenotypic characteristics, such as fundus appearance. Biofluid markers may be useful to help predict incidence and prevalence of the disease, but reliable markers are still lacking.…”