Oxidative Stress and Antioxidant Activity in Hypothermia and Rewarming: Can RONS Modulate the Beneficial Effects of Therapeutic Hypothermia?

Alva, Norma; Palomeque, J.; Carbonell, Teresa

doi:10.1155/2013/957054

Cited by 64 publications

(33 citation statements)

References 93 publications

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“…Hypothermia is routinely used as a protective therapeutic tool for moderate to severe HIE in clinical application [56]. Selective head cooling (34.5 °C) and total body cooling (33.5 °C) are the two therapeutic hypothermia methods.…”

Section: Clinical Strategies Of Antioxidants In Hiementioning

confidence: 99%

Oxidative Stress in Hypoxic-Ischemic Encephalopathy: Molecular Mechanisms and Therapeutic Strategies

Zhao

Zhu

Fujino

et al. 2016

IJMS

165

108

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Hypoxic-ischemic encephalopathy (HIE) is one of the leading causes of morbidity and mortality in neonates. Because of high concentrations of sensitive immature cells, metal-catalyzed free radicals, non-saturated fatty acids, and low concentrations of antioxidant enzymes, the brain requires high levels of oxygen supply and is, thus, extremely sensitive to hypoxia. Strong evidence indicates that oxidative stress plays an important role in pathogenesis and progression. Following hypoxia and ischemia, reactive oxygen species (ROS) production rapidly increases and overwhelms antioxidant defenses. A large excess of ROS will directly modify or degenerate cellular macromolecules, such as membranes, proteins, lipids, and DNA, and lead to a cascading inflammatory response, and protease secretion. These derivatives are involved in a complex interplay of multiple pathways (e.g., inflammation, apoptosis, autophagy, and necrosis) which finally lead to brain injury. In this review, we highlight the molecular mechanism for oxidative stress in HIE, summarize current research on therapeutic strategies utilized in combating oxidative stress, and try to explore novel potential clinical approaches.

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Section: Clinical Strategies Of Antioxidants In Hiementioning

confidence: 99%

Oxidative Stress in Hypoxic-Ischemic Encephalopathy: Molecular Mechanisms and Therapeutic Strategies

Zhao

Zhu

Fujino

et al. 2016

IJMS

165

108

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show abstract

“…(8,9) The neuroprotective mechanisms of TTM include the attenuation of oxidative stress and antiinflammatory effects. (10)(11)(12)(13) However, recent studies reported that TTM does not exert beneficial effects on cytokine levels in PCAS. (6,(14)(15)(16)(17) Molecular hydrogen (H 2 ) is a mild antioxidant that selectively reduces highly active oxidants such as hydroxyl radicals and peroxynitrites.…”

mentioning

confidence: 99%

Hydrogen gas inhalation alleviates oxidative stress in patients with post-cardiac arrest syndrome

Tamura

Suzuki

Hayashida

et al. 2020

J. Clin. Biochem. Nutr.

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Oxidative stress plays a key role in the pathophysiology of post cardiac arrest syndrome. Molecular hydrogen reduces oxidative stress and exerts anti inflammatory effects in an animal model of cardiac arrest. However, its effect on human post cardiac arrest syndrome is unclear. We consecutively enrolled five comatose post cardiac arrest patients (three males; mean age, 65 ± 15 years; four cardiogenic, one septic cardiac arrest) and evaluated temporal changes in oxidative stress markers and cytokines with inhaled hydrogen. All patients were treated with target temperature management. Hydrogen gas inhalation (2% hydrogen with titrated oxygen) was initiated upon admission for 18 h. Blood hydrogen concentrations, plasma and urine oxidative stress markers (derivatives of reactive oxygen metabolites, biological antioxidant potential, 8 hydroxy 2' deoxyguanosine, N ε hexanoyl lysine, lipid hydroperoxide), and cytokines (interleukin 6 and tumor necrosis factor α) were measured before and 3, 9, 18, and 24 h after hydrogen gas inhalation. Arterial hydrogen concentration was measurable and it was equilibrated with inhaled hydrogen. Oxidative stress was reduced and cytokine levels were unchanged in cardiogenic patients, whereas oxidative stress was unchanged and cytokine levels were diminished in the septic patient. The effect of inhaled hydrogen on oxidative stress and cytokines in comatose post cardiac arrest patients remains indefinite because of methodological weaknesses.

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“…Moreover, HBH exposure also led to hypothermia, however, no change was observed in UCP1 and SIRT 1 levels in HBH exposed animals. The unconventional link between oxidative stress and hypothermia has elsewhere been described (Alva, Palomeque, & Carbonell, ) and mild hypothermia has shown therapeutic effects against ischemia (Zhao et al, ). Interestingly, extract modulated UCP1 and SIRT1 in cold stress while thermogenic response of extract was independent of UCP1 and SIRT1 under hypoxia stress which needs further investigation.…”

Section: Discussionmentioning

confidence: 97%

Pharmacological effects ofGanoderma lucidumextract against high‐altitude stressors and its subchronic toxicity assessment

Sharma

Tulsawani

Agrawal³

2019

J Food Biochem

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Acclimatization is a major pathophysiological concern during ascent to high altitude and may cause mortality in unacclimatized individuals. Absence of target drugs, especially prophylactics, emphasizes the need for development of herbal agents. Present study revealed that animals pre‐administered with aqueous extract of Ganoderma lucidum (GLAQ) dose dependently (50, 100, 200 mg/kg) delayed onset of convulsion following severe hypoxia (SH) and restored rectal temperature post‐cold restraint (CR) and hypobaric hypoxia (HBH). The compromised antioxidant status (MDA, GSH, SOD, GPx), biochemical (ALT, AST, glucose, triglycerides, cholesterol, urea), and hematological parameters (red blood cells, white blood cells) were ameliorated with GLAQ treatment. Further, extract modulated inflammatory and thermogenic response by attenuating pro‐inflammatory cytokines (NFĸB, TNFα, IL6) and restoring UCP1, SIRT1, respectively. Notably, extract did not produce any noxious effects subchronically in rats of both sexes with GLAQ administered at 100, 500, and 1,000 mg/kg in a single dose/day for 90 days, deeming it fit for therapeutic purpose. Practical applications GLAQ exhibited better efficacy compared to internal control (gallic acid) suggest that array of bioactive compounds in extract might contribute toward efficacy. Further, antistress properties of GLAQ against multiple stressors including SH, CR, and HBH demonstrate its therapeutic potential for inducing rapid acclimatization and preventing mountain sickness. Conclusively, the present study based on Ganoderma lucidum extract intents to fill the lacunae behind development of nontoxic therapeutic agent for controlling high altitude‐related maladies.

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Oxidative Stress and Antioxidant Activity in Hypothermia and Rewarming: Can RONS Modulate the Beneficial Effects of Therapeutic Hypothermia?

Cited by 64 publications

References 93 publications

Oxidative Stress in Hypoxic-Ischemic Encephalopathy: Molecular Mechanisms and Therapeutic Strategies

Oxidative Stress in Hypoxic-Ischemic Encephalopathy: Molecular Mechanisms and Therapeutic Strategies

Hydrogen gas inhalation alleviates oxidative stress in patients with post-cardiac arrest syndrome

Pharmacological effects ofGanoderma lucidumextract against high‐altitude stressors and its subchronic toxicity assessment

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