Oxidative Stress and Antioxidant Nanotherapeutic Approaches for Inflammatory Bowel Disease

Liu, Ping; Li, Yixuan; Wang, Ran; Ren, Fazheng; Wang, Xiaoyu

doi:10.3390/biomedicines10010085

Cited by 17 publications

(7 citation statements)

References 110 publications

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“…Numerous pieces of evidence suggest that IBD is linked to the increased production of reactive species [ 56 ]. Oxidative stress not only directly disrupts the intestinal barrier, which leads to cell dysfunction and tissue damage in the colon, but also causes dysregulation of multiple cell types, such as intestinal epithelial cells and immune cells [ 56 , 57 ]. To determine the impact of CMC-AXT-NPs on oxidative stress in mice with UC, the levels of oxidative stress markers were measured.…”

Section: Resultsmentioning

confidence: 99%

Oral Delivery of Astaxanthin via Carboxymethyl Chitosan-Modified Nanoparticles for Ulcerative Colitis Treatment

Zhang,

et al. 2024

Molecules

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The oral delivery strategy of natural anti-oxidant and anti-inflammatory agents has attracted great attention to improve the effectiveness of ulcerative colitis (UC) treatment. Herein, we developed a novel orally deliverable nanoparticle, carboxymethyl chitosan (CMC)-modified astaxanthin (AXT)-loaded nanoparticles (CMC-AXT-NPs), for UC treatment. The CMC-AXT-NPs were evaluated by appearance, morphology, particle size, ζ-potential, and encapsulation efficiency (EE). The results showed that CMC-AXT-NPs were nearly spherical in shape with a particle size of 34.5 nm and ζ-potential of −30.8 mV, and the EE of CMC-AXT-NPs was as high as 95.03%. The CMC-AXT-NPs exhibited preferable storage stability over time and well-controlled drug-release properties in simulated intestinal fluid. Additionally, in vitro studies revealed that CMC-AXT-NPs remarkably inhibited cytotoxicity induced by LPS and demonstrated superior antioxidant and anti-inflammatory abilities in Raw264.7 cells. Furthermore, CMC-AXT-NPs effectively alleviated clinical symptoms of colitis induced by dextran sulfate sodium salt (DSS), including maintaining body weight, inhibiting colon shortening, and reducing fecal bleeding. Importantly, CMC-AXT-NPs suppressed the expression of pro-inflammatory cytokines like TNF-α, IL-6, and IL-1β and ameliorated DSS-induced oxidative damage. Our results demonstrated the potential of CMC-modified nanoparticles as an oral delivery system and suggested these novel AXT nanoparticles could be a promising strategy for UC treatment.

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Section: Resultsmentioning

confidence: 99%

Oral Delivery of Astaxanthin via Carboxymethyl Chitosan-Modified Nanoparticles for Ulcerative Colitis Treatment

Zhang,

et al. 2024

Molecules

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“…Besides, P. distasonis possesses catalase and oxidative stress tolerance genes such as KatE gene and the OxyR gene ( Ezeji et al, 2021 ). Oxidative stress is associated with the initiation and progress of IBD while catalase is an important factor in oxidative stress tolerance ( Knaus et al, 2017 ; Liu et al, 2021 ). While DNA transcription, protein translation, biosynthesis, and spore-forming are accounted for a large proportion of functional annotation in the downregulated species at the remission stage.…”

Section: Discussionmentioning

confidence: 99%

The Distinguishing Bacterial Features From Active and Remission Stages of Ulcerative Colitis Revealed by Paired Fecal Metagenomes

Zhu

Tang²,

Xing³

et al. 2022

Front. Microbiol.

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Ulcerative colitis (UC) is a serious chronic intestinal inflammatory disease, with an increased incidence in recent years. The intestinal microbiota plays a key role in the pathogenesis of UC. However, there is no unified conclusion on how the intestinal microbiota changes. Most studies focus on the change between UC patients and healthy individuals, rather than the active and remission stage of the same patient. To minimize the influences of genetic differences, environmental and dietary factors, we studied the intestinal microbiota of paired fecal samples from 42 UC patients at the active and remission stages. We identified 175 species of microbes from 11 phyla and found no difference of the alpha and beta diversities between the active and remission stages. Paired t-test analysis revealed differential microbiota at levels of the phyla, class, order, family, genus, and species, including 13 species with differential abundance. For example, CAG-269 sp001916005, Eubacterium F sp003491505, Lachnospira sp000436475, et al. were downregulated in the remission, while the species of Parabacteroides distasonis, Prevotellamassilia sp900540885, CAG-495 sp001917125, et al. were upregulated in the remission. The 13 species can effectively distinguish the active and remission stages. Functional analysis showed that the sporulation and biosynthesis were downregulated, and the hydrogen peroxide catabolic process was upregulated in remission of UC. Our study suggests that the 13 species together may serve as a biomarker panel contributing to identify the active and remission stages of UC, which provides a valuable reference for the treatment of UC patients by FMT or other therapeutic methods.

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“…Numerous studies have shown the efficacy of phytochemicals against TLR4-mediated inflammation ( Figure 1 ) ( 137 , 138 ). Flavonoids such as quercetin, catechin, and silymarin have proven therapeutic efficacy in the treatment of IBD ( Figure 3 ) ( 139 , 140 ). Here, they operate as effective antioxidants and cellular modulators of the protein kinase and lipid kinase signaling pathways that drive chronic intestinal inflammation ( 139 , 140 ).…”

Section: Role Of Antioxidants For Ibd-related Therapeutic Application...mentioning

confidence: 99%

“…Flavonoids such as quercetin, catechin, and silymarin have proven therapeutic efficacy in the treatment of IBD ( Figure 3 ) ( 139 , 140 ). Here, they operate as effective antioxidants and cellular modulators of the protein kinase and lipid kinase signaling pathways that drive chronic intestinal inflammation ( 139 , 140 ). Dogs with idiopathic IBD also have up-regulated activity of the JAK/STAT pathway marked by phosphorylated STAT3 (pSTAT3) overexpression ( 141 ).…”

Section: Role Of Antioxidants For Ibd-related Therapeutic Application...mentioning

confidence: 99%

Oxidative stress, hormones, and effects of natural antioxidants on intestinal inflammation in inflammatory bowel disease

Sahoo,

Heilmann,

Paital

et al. 2023

Front. Endocrinol.

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Inflammatory bowel disease (IBD) is a chronic, relapsing gastrointestinal (GI) disorder characterized by intestinal inflammation. The etiology of IBD is multifactorial and results from a complex interplay between mucosal immunity, environmental factors, and host genetics. Future therapeutics for GI disorders, including IBD, that are driven by oxidative stress require a greater understanding of the cellular and molecular mechanisms mediated by reactive oxygen species (ROS). In the GI tract, oxidative stressors include infections and pro-inflammatory responses, which boost ROS generation by promoting the production of pro-inflammatory cytokines. Nuclear factor kappa B (NF-κB) and nuclear factor erythroid 2–related factor 2 (Nrf2) represent two important signaling pathways in intestinal immune cells that regulate numerous physiological processes, including anti-inflammatory and antioxidant activities. Natural antioxidant compounds exhibit ROS scavenging and increase antioxidant defense capacity to inhibit pro-oxidative enzymes, which may be useful in IBD treatment. In this review, we discuss various polyphenolic substances (such as resveratrol, curcumin, quercetin, green tea flavonoids, caffeic acid phenethyl ester, luteolin, xanthohumol, genistein, alpinetin, proanthocyanidins, anthocyanins, silymarin), phenolic compounds including thymol, alkaloids such as berberine, storage polysaccharides such as tamarind xyloglucan, and other phytochemicals represented by isothiocyanate sulforaphane and food/spices (such as ginger, flaxseed oil), as well as antioxidant hormones like melatonin that target cellular signaling pathways to reduce intestinal inflammation occurring with IBD.

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Oxidative Stress and Antioxidant Nanotherapeutic Approaches for Inflammatory Bowel Disease

Cited by 17 publications

References 110 publications

Oral Delivery of Astaxanthin via Carboxymethyl Chitosan-Modified Nanoparticles for Ulcerative Colitis Treatment

Oral Delivery of Astaxanthin via Carboxymethyl Chitosan-Modified Nanoparticles for Ulcerative Colitis Treatment

The Distinguishing Bacterial Features From Active and Remission Stages of Ulcerative Colitis Revealed by Paired Fecal Metagenomes

Oxidative stress, hormones, and effects of natural antioxidants on intestinal inflammation in inflammatory bowel disease

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