Oxidative Stress and Antioxidant Pathway in Allergic Rhinitis

Han, Mun Soo; Lee, Dabin; Lee, Sang Hag; Kim, Tae Hoon

doi:10.3390/antiox10081266

Cited by 39 publications

(29 citation statements)

References 102 publications

(129 reference statements)

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“…And due to the higher requirement of iron than manganese, a substitution of iron with manganese occurs when iron concentration decreased during growth; therefore, the concentration of SOD-Mn increased. As for doubling that GPX concentration, Han et al [45] explained that it increased when the cells are exposed to oxidative stresses.…”

Section: Defense or Antioxidant Enzymesmentioning

confidence: 99%

Biotechnological studies on Arthrospira platensis biomass cultivated in enriched culture with chelated leather waste and chelated glycinate

Jacob

Afify²,

Shanab³

et al. 2022

Biomass Conv. Bioref.

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The current work aims to evaluate the growth rate, molecular patterns and biological activities of Arthrospira platensis cultivated in culture enriched with different chelated minerals (Fe, Zn, Cu, Mn, and Mg) of leather protein hydrolysates (LPHs) and glycine in addition to determine the phytochemical contents of Arthrospira platensis cultivated in modified Zarrouk medium. Also, the work study the protein profile with molecular variations (using SDS-PAGE, Comet assay, and SCOT-PCR) in collected biomasses when compared with control (cyanobacteria cultivated in Zarrouk medium). Superoxide dismutase (SOD), glutathione peroxidase (GPX), and mineral content of each treatment were also determined. The obtained Results showed that a significant increment of growth rate of A. platensis in glycinate treatments was observed especially with Cu-glycinate more than control medium. Additionally, T11 has high O.D. than other chelated minerals but control medium had the highest O.D. than LW-chelated minerals. All A. platensis treated with the glycine-chelates possessed both conserved and additional proteins in their SDS-PAGE banding patterns. Moreover, A. platensis treated by chelated minerals with leather waste hydrolysate induced high discrimination than their analogues chelated with glycine. Six ScoT primers were applied and produced 323 amplicons with an average of 68% polymorphism/primer. SDS and Scot dendrogram revealed that among all treatments, control and Mg-glycine-chelated treatment were closely related. All A. platensis samples treated by chelated minerals with leather waste hydrolysate possessed more polymorphic bands than monomorphic ones (either as proteins or DNA), despite that no significant DNA damage (as % tDNA) was detected on A. platensis treated with either chelated treatment.

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Section: Defense or Antioxidant Enzymesmentioning

confidence: 99%

Biotechnological studies on Arthrospira platensis biomass cultivated in enriched culture with chelated leather waste and chelated glycinate

Jacob

Afify²,

Shanab³

et al. 2022

Biomass Conv. Bioref.

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“…Although AR does not cause death, its clinical symptoms can have serious effects on patients' daily activities (e.g., sleep habits, cognitive function, work, etc.) and overall quality of life 3–5 . AR is usually accompanied by asthma, atopic disease, sinusitis, conjunctivitis and otitis media, thus complicating the treatment and management of patients 6 .…”

Section: Introductionmentioning

confidence: 99%

Association between IL1RL1 gene polymorphisms and allergic rhinitis risk in the Chinese Han population

Ren

Zhang

et al. 2022

Clinical Laboratory Analysis

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Background Although it has been confirmed that IL1RL1 is involved in the occurrence of allergic rhinitis (AR), the role of IL1RL1 gene single nucleotide polymorphisms (SNPs) in AR is still unclear. Methods We performed a case–control study including 1000 AR patients and 1000 healthy controls. The four SNPs rs72823628 G > A, rs950881 G > T, rs72823641 T > A and rs3771175 T > A in IL1RL1 were chosen and genotyped using Agena MassARRAY platform. The relationship between IL1RL1 SNPs and AR risk was analyzed by logistic regression and assessed with odds ratios (ORs) and corresponding 95% confidence intervals (95% CIs). Results Overall analysis revealed that IL1RL1 gene rs72823628, rs950881 and rs3771175 were associated with a reduced AR risk. Stratified analysis showed that the three SNPs (rs72823628, rs950881 and rs3771175) were obviously linked to a reduced risk of AR in males. Moreover, no correlation was observed between haplotypes and reduced AR risk after the false discovery rate (FDR) correction. The false positive report probability (FPRP) analysis was used to further validate significant findings. Conclusion Our study is the first to indicate that IL1RL1 gene polymorphisms (rs72823628, rs950881 and rs3771175) may be correlated with decreased risk of AR in the Chinese Han population.

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“…Under oxidative stress conditions, Nrf2 is separated from Keap1 and translocated into the nucleus, where it binds to the antioxidant response element and induces the expression of antioxidant enzymes such as heme oxygenase-1 (HO-1), NAD(P)H, quinone oxidoreductase (NQO1), and superoxide dismutase (SOD) [ 22 , 23 ]. These antioxidant enzymes promote ROS detoxification and serve as biomarkers of oxidative stress [ 24 , 25 ]. To treat AR, it is also necessary to regulate antioxidant activity and ROS production.…”

Section: Introductionmentioning

confidence: 99%

Caesalpinia sappan Linn. Ameliorates Allergic Nasal Inflammation by Upregulating the Keap1/Nrf2/HO-1 Pathway in an Allergic Rhinitis Mouse Model and Nasal Epithelial Cells

Pyun

Lee

et al. 2022

Antioxidants

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Allergic rhinitis (AR) is a common upper-airway inflammatory disease of the nasal mucosa caused by immunoglobulin (IgE)-mediated inflammation. AR causes various painful clinical symptoms of the nasal mucosa that worsen the quality of daily life, necessitating the urgent development of therapeutic agents. Herein, we investigated the effects of Caesalpinia sappan Linn. heartwood water extract (CSLW), which has anti-inflammatory and antioxidant properties, on AR-related inflammatory responses. We examined the anti-inflammatory and anti-allergic effects of CSLW in ovalbumin (OVA)-induced AR mice and in primary human nasal epithelial cells (HNEpCs). Administration of CSLW mitigated allergic nasal symptoms in AR mice, decreased total immune cell and eosinophil counts in nasal lavage fluid, and significantly reduced serum levels of OVA-specific IgE, histamine, and Th2 inflammation-related cytokines. CSLW also inhibited the infiltration of several inflammatory and goblet cells, thereby ameliorating OVA-induced thickening of the nasal mucosa tissue. We found that CSLW treatment significantly reduced infiltration of eosinophils and production of periostin, MUC5AC, and intracellular reactive oxygen species through the Keap1/Nrf2/HO-1 pathway in HNEpCs. Thus, our findings strongly indicate that CSLW is a potent therapeutic agent for AR and can improve the daily life of patients by controlling the allergic inflammatory reaction of the nasal epithelium.

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Oxidative Stress and Antioxidant Pathway in Allergic Rhinitis

Cited by 39 publications

References 102 publications

Biotechnological studies on Arthrospira platensis biomass cultivated in enriched culture with chelated leather waste and chelated glycinate

Biotechnological studies on Arthrospira platensis biomass cultivated in enriched culture with chelated leather waste and chelated glycinate

Association between IL1RL1 gene polymorphisms and allergic rhinitis risk in the Chinese Han population

Caesalpinia sappan Linn. Ameliorates Allergic Nasal Inflammation by Upregulating the Keap1/Nrf2/HO-1 Pathway in an Allergic Rhinitis Mouse Model and Nasal Epithelial Cells

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