Oxidative stress and antioxidant responses of liver and kidney tissue after implantation of titanium or titanium oxide coated plate in rat tibiae

Abstract

Coating with titanium oxides is a promising method to improve the blood compatibility of materials to be used for medical implants. However, biodegradation of the coating can result in microparticles that subsequently cause oxidative stress. Therefore, the present study was carried out to throw some light on the mechanisms affecting the reaction of tissue surroundings Ti implants either in the form of titanium oxide or not in tibiae of rats. The serum collected twice from animals during the period of study and rats were sacrificed after two months of implantation. The complete blood picture, total proteins content and the activities of some serum enzymes were determined as liver biomarker. Kidney function was examined by measuring the levels of serum creatinine and uric acid. The level of lipid peroxidation and the activities of superoxide dismutase, catalase and glutathione S-transferase as well as glutathione content in liver and kidney tissue were evaluated. It has been indicated that the lipid peroxidation is one of the molecular mechanisms involved in Ti-plate induced cytotoxicity however; the TiO(2)-plate did not. The biodegradation of Ti-plate was very slow that could explain why the all enzymatic and non-enzymatic antioxidant not affected by implantation of Ti-plate. The total antioxidant level in serum was better in rats had TiO(2)/Ti-plate than those animals that had Ti-plate. The coating of titanium implants with titanium oxide leads to attaining of reduced the oxidative state in the cells, which enhance the healing process in comparison with the uncoated implants.

Construction of Nanophase Novel Coatings-Based Titanium for the Enhancement of Protein Adsorption

“…1c) shows that the anodization of TNP at 20 V for 2 h in the safe chloride bath at room temperature is considered as the optimum anodizing condition to form a spongy homogeneous nanoporous layer from TiO 2 . This observation is agreement with other reports [30]. The presence of 15 wt% of oxygen in the EDX analysis of ATNP surface can be explained due to the formation of TiO 2 film.…”

Surface Modification of Titanium Plate with Anodic Oxidation and Its Application in Bone Growth

“…These results are fully compatible with the findings of researchers [48]. The surface properties of biomaterials play a critical role in the establishment of cell-biomaterial interfaces [49].…”

Titanium dioxide dental implants surfaces related oxidative stress in bone remodeling: a systematic review

“…Of the fourteen studies, five publications were undertaken in vitro ; most of them were performed in China ( Zhang et al, 2011 ; Xie et al, 2014 ; Yu et al, 2018 ; Shen et al, 2019 ) and only one was performed in Poland ( Niska et al, 2015 ). Other five studies were conducted in vitro/vivo , three of them performed in China ( Hu et al, 2018 ; Yang et al, 2020 ; Huang et al, 2021 ), One in Saudi Arabia ( El-Shenawy et al, 2012 ) and one in Korea ( Lee et al, 2013 ). The last four studies were done in humans and, three of them performed in Italy ( Pietropaoli et al, 2013 ; Mariarosaria et al, 2017 ; Mijiritsky et al, 2019 ) and one in Poland ( Borys et al, 2018 ).…”

“…The fourteen articles that were chosen did not all shed the light on the same type of titanium dioxide, in fact 6 of those ( El-Shenawy et al, 2012 ; Lee et al, 2013 ; Yu et al, 2018 ; Shen et al, 2019 ; Yang et al, 2020 ; Huang et al, 2021 ) focused on of titanium dioxide nanotube effect on oxidative stress and osteogenesis and 3 studies ( Zhang et al, 2011 ; Xie et al, 2014 ; Niska et al, 2015 ) focused on the effect of titanium dioxide nanoparticles on oxidative stress and osteogenesis therefore, highlighting theses results were done first.…”