Oxidative stress and antioxidant status in elderly diabetes mellitus and glucose intolerance patients

Atlı, Teslime; Keven, Kenan; Avcı, Aslıhan; Kutlay, Sim; Türkçapar, Nuran; Varlı, Murat; Aras, Sevgi; Ertuğ, Ergün; Canbolat, Orhan

doi:10.1016/j.archger.2004.04.065

Cited by 64 publications

(42 citation statements)

References 21 publications

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“…Although we do not have yet an exact explanation for the differential region-specific increase of these antioxidant enzyme activities, this may result from adaptation at the transcription level to sustained production of reactive species (Harris 1992), mainly superoxide radical and hydrogen peroxide scavenged by SOD and catalase, respectively. Therefore, augmented SOD and CAT activities in the mutant mice may represent a compensatory upregulation of protein synthesis induced by chronic misbalance of pro-oxidant/antioxidant status in deficient animals (Atli et al 2004;Koch et al 2004;Mecocci et al 2000;Rohrdanz et al 2001).…”

Section: Discussionmentioning

confidence: 97%

Evidence for oxidative stress in tissues derived from succinate semialdehyde dehydrogenase‐deficient mice

Latini

Scussiato

Leipnitz

et al. 2007

J of Inher Metab Disea

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Animal models of inborn errors of metabolism are useful for investigating the pathogenesis associated with the corresponding human disease. Since the mechanisms involved in the pathophysiology of succinate semialdehyde dehydrogenase (SSADH) deficiency (Aldh5a1; OMIM 271980) are still not established, in the present study we evaluated the tissue antioxidant defences and lipid peroxidation in various cerebral structures (cortex, cerebellum, thalamus and hippocampus) and in the liver of SSADH-deficient mice. The parameters analysed were total radical-trapping antioxidant potential (TRAP) and glutathione (GSH) levels, the activities of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx), as well as thiobarbituric acid-reactive substances (TBARS). We first observed that the tissue nonenzymatic antioxidant defences were significantly reduced in the SSADH-deficient animals, particularly in the liver (decreased TRAP and GSH) and in the cerebral cortex (decreased GSH), as compared to the wild-type mice. Furthermore, SOD activity was significantly increased in the liver and cerebellum, whereas the activity of CAT was significantly higher in the thalamus. In contrast, GPx activity was significantly diminished in the hippocampus. Finally, we observed that lipid peroxidation (TBARS levels) was markedly increased in the liver and cerebral cortex, reflecting a high lipid oxidative damage in these tissues. Our data showing an imbalance between tissue antioxidant defences and oxidative attack strongly indicate that oxidative stress is involved in the pathophysiology of SSADH deficiency in mice, and likely the corresponding human disorder.

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Section: Discussionmentioning

confidence: 97%

Evidence for oxidative stress in tissues derived from succinate semialdehyde dehydrogenase‐deficient mice

Latini

Scussiato

Leipnitz

et al. 2007

J of Inher Metab Disea

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“…Since both groups of GI subjects had comparable fasting and 2-h plasma glucose levels, one possible reason for the difference in serum Hsp27 concentration is that endothelial cells of GI subjects without CVD may not be exposed to oxidative stress due to the possible differences in antioxidant status (Bhatia et al 2003;Atli et al 2004;Ozdemir et al 2005;Ceriello et al 2000).…”

Section: Discussionmentioning

confidence: 99%

Serum heat shock protein 27 antigen and antibody levels appear to be related to the macrovascular complications associated with insulin resistance: a pilot study

Burut

Borai

Livingstone

et al. 2010

Cell Stress and Chaperones

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Heat shock protein 27 (Hsp27) is over-expressed when cells are exposed to stressful conditions that include oxidative stress. Oxidative stress has been implicated in the pathogenesis of cardiovascular disease (CVD), diabetes and insulin resistance. We have investigated the concentrations of serum Hsp27 antigen and antibodies in subjects from different glycaemic categories, who either did or did not have established CVD. Serum Hsp27 antigen and antibody levels (immunoglobulins M and G (IgM and IgG)) were determined by enzyme-linked immunosorbent assays (ELISAs) in 68 individuals: 26 with normal glucose tolerance (NGT), 10 with (+) and 16 without (-) a history of CVD and 42 individuals with varying degrees of glucose intolerance (GI; 21 with and 21 without a history of CVD). Insulin sensitivity was determined in each subject using indices derived from the homeostasis model assessment of sensitivity and the insulin sensitivity index for glycaemia. Serum Hsp27 concentrations were significantly higher in GI (+CVD) subjects compared to GI (-CVD) subjects (p = 0.03), NGT (-CVD) subjects (p = 0.02) and NGT (+CVD) subjects (p = 0.04) and were positively correlated to fasting plasma glucose for all subjects (r = 0.28, p = 0.03). IgM antibody levels were significantly higher in GI (+CVD) subjects compared to NGT (-CVD) group (p = 0.02) and were inversely related to fasting insulin concentrations (r = -0.27, p = 0.04) and the 2-h insulin concentrations (r = -0.29, p = 0.03) for all subjects. Serum IgG antibody levels were higher in GI (+CVD) group compared to GI (-CVD) group (p = 0.06). In conclusion, Hsp27 and its antibody concentrations appear to relate to the presence of cardiovascular complications in patients with GI.

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“…Increased oxidative stress and impaired antioxidant defence have been suggested to contribute to initiation and progression of diabetes and glucose intolerance (31,32). Moderate increase in glucose could affect oxidative status (32), and the balance between several components of the anti-oxidant defence appears to be sensitive to glucose levels.…”

Section: Trace Elements and Antioxidant Enzymes With Regard To Glucosmentioning

confidence: 98%

Antioxidants, trace elements and metabolic syndrome in elderly subjects

Pizent

Pavlović

Jurasović

et al. 2010

The Journal of nutrition, health and aging

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Oxidative stress and antioxidant status in elderly diabetes mellitus and glucose intolerance patients

Cited by 64 publications

References 21 publications

Evidence for oxidative stress in tissues derived from succinate semialdehyde dehydrogenase‐deficient mice

Evidence for oxidative stress in tissues derived from succinate semialdehyde dehydrogenase‐deficient mice

Serum heat shock protein 27 antigen and antibody levels appear to be related to the macrovascular complications associated with insulin resistance: a pilot study

Antioxidants, trace elements and metabolic syndrome in elderly subjects

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