Oxidative Stress and Antioxidant Status in Immune Thrombocytopenia

Li, Xuewei; Wang, Zhaoyue; Qi, Xiaofei; Dong-jie, Zhang

doi:10.4172/2155-9864.1000392

Cited by 2 publications

(1 citation statement)

References 42 publications

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“…As mentioned previously, MIS-C has been associated due to its clinical characteristics with other inflammatory syndromes (TSS and KD), for which some common pathways and divergences are mentioned that may explain the participation of OS in MIS-C. It has been proposed that platelet count can help differentiate KD and MIS-C, since KD patients are characterized by normal/high platelet counts while MIS-C patients commonly present with lower platelet counts (70) which leads us to reinforce our hypothesis that OS could be involved in this process, as occurs in immune thrombocytopenia (IT), in which multiple lines of evidence suggest that OS participates in the pathogenesis of this disorder, observing elevation of lipid peroxidation and the reduction of antioxidant capacity, as well as the use of antioxidants improves the prognosis in these patients (71,72). It has also been described that patients with acute MIS-C present increased binding of antibodies to antigens associated with the development of the endothelium and the heart and other common targets with autoimmunity compared to healthy controls (73).…”

Section: Influence Of Os On the Pathophysiology Of Mis-csupporting

confidence: 71%

Multisystem Inflammatory Syndrome in Children (MIS-C) Following SARS-CoV-2 Infection: Role of Oxidative Stress

et al. 2021

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With the appearance of the SARS-CoV-2 virus in December 2019, all countries in the world have implemented different strategies to prevent its spread and to intensively search for effective treatments. Initially, severe cases of the disease were considered in adult patients; however, cases of older school-age children and adolescents who presented fever, hypotension, severe abdominal pain and cardiac dysfunction, positive for SARS-CoV-2 infection, have been reported, with increased pro-inflammatory cytokines and tissue damage, condition denominated multisystemic inflammatory syndrome (MIS-C); The emerging data from patients with MIS-C have suggested unique characteristics in the immunological response and also clinical similarities with other inflammatory syndromes, which can support as a reference in the search for molecular mechanisms involved in MIS-C. We here in propose that oxidative stress (OE) may play a very important role in the pathophysiology of MIS-C, such as occurs in Kawasaki disease (KD), severe COVID-19 in adults and other processes with characteristics of vascular damage similar to MIS- C, for which we review the available information that can be correlated with possible redox mechanisms.

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Section: Influence Of Os On the Pathophysiology Of Mis-csupporting

confidence: 71%

Multisystem Inflammatory Syndrome in Children (MIS-C) Following SARS-CoV-2 Infection: Role of Oxidative Stress

et al. 2021

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Antioxidants as supplements during drug-induced thrombocytopenia: a comparative analysis of Vanillic acid, L-carnitine and Caripill™

Mithun,

Rajashekaraiah

2024

Ukr.Biochem.J.

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Drug-induced thrombocytopenia (DIT) is a disorder where platelet count declines as an adverse effect of therapeutic drugs. Plant extract of C. papaya Caripill™ is known to elevate platelet count under thrombocytopenic conditions. To evaluate the contribution of supplements with antioxidant potential to treat DIT, the comparative study of Caripill™, vanillic acid L-carnitine effect on platelet count and indices of oxidative stress in a model of rat thrombocytopenia induced through oral administration of hydroxyurea was performed. Wistar rats were grouped into four categories with five animals in each group: control (without any treatment); control + antioxidants; thrombocytopenia; thrombocytopenia + antioxidants. The above-mentioned antioxidants were supplemented orally at 50 mg/kg for 7 days. The level of lipid peroxidation products, superoxides, protein carbonyls and sulfhydryls, SOD and CAT activity in isolated platelets as oxidative stress markers, and indices of platelets aggregation and ATP secretion as functional markers were used. Vanillic acid was shown to be beneficial, similar to Caripill™, during hydroxyurea-induced thrombocytopenia by maintaining platelet functions, enhancing both the antioxidant capacity of platelets and its number. L-carnitine efficiently up-regulated the enzymatic antioxidants, maintained platelet functions and protected lipids and proteins from oxidation in thrombocytopenic rats, however, it could not improve the platelet count. These findings open new avenues for employing the studied antioxidants as supplements for therapeutic purposes.

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Oxidative Stress and Antioxidant Status in Immune Thrombocytopenia

Cited by 2 publications

References 42 publications

Multisystem Inflammatory Syndrome in Children (MIS-C) Following SARS-CoV-2 Infection: Role of Oxidative Stress

Multisystem Inflammatory Syndrome in Children (MIS-C) Following SARS-CoV-2 Infection: Role of Oxidative Stress

Antioxidants as supplements during drug-induced thrombocytopenia: a comparative analysis of Vanillic acid, L-carnitine and Caripill™

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