Oxidative stress and antioxidants in diabetes mellitus

Ghasemi‐Dehnoo, Maryam; Amini‐Khoei, Hossein; Lorigooini, Zahra; Rafieian-Kopaei, Mahmoud

doi:10.4103/1995-7645.291036

Cited by 34 publications

(20 citation statements)

References 3 publications

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“…Clinical studies of the OS reactions in DM. Most case-control studies postulate an increase in biomarkers of oxidative damage to lipids, proteins, and nucleic acids in patients with prediabetes and with DM1 and DM2 in comparison with the controls [31,35,44]. Similar results were obtained in patients with DM and micro-and macrovascular complications in comparison with the groups data without micro-and macrovascular complications [71,83].…”

Section: Deactivation Of the Insulin Signaling Pathwaymentioning

confidence: 68%

“…It was found that even short-term exposure to hyperglycemia leads to a selective increase in the expression of iNOS gene, followed by an increase in NO. Simultaneous elevation of NO and superoxide radicals increases the formation of peroxynitrite, which is a strong oxidant with a toxic effect on the vascular network, which can contribute to the disease progression and myocardium damage [33,44]. Various isoforms of NOX are expressed in monocytes, macrophages, and vascular cells, and both perform a protective role and contribute to the development of endothelial dysfunction and inflammation [44].…”

Section: Deactivation Of the Insulin Signaling Pathwaymentioning

confidence: 99%

“…Simultaneous elevation of NO and superoxide radicals increases the formation of peroxynitrite, which is a strong oxidant with a toxic effect on the vascular network, which can contribute to the disease progression and myocardium damage [33,44]. Various isoforms of NOX are expressed in monocytes, macrophages, and vascular cells, and both perform a protective role and contribute to the development of endothelial dysfunction and inflammation [44]. Activation of PKC, AP-2 and AGE generation, increase the expression of NOX isoforms in monocytes and macrophages, stimulate ROS increase, as well as the synthesis of proinflammatory proteins such as IL-6, monocyte chemoattractant protein 1 (MCP-1), and intercellular adhesion molecules 1 (ICAM-1) [55,89].…”

Section: Deactivation Of the Insulin Signaling Pathwaymentioning

confidence: 99%

“…These indicators were elevated and closely correlated with unsatisfactory control of glycaemia and DM2 course severity. In most studies, 8-iso-prostaglandin F2α (8-iso-PGF2a) and 8-OHdG levels in plasma and urine were also elevated in the prediabetic stage [44,72]. These biomarkers measured in urine are considered significant in predicting micro-and macrovascular complications of DM2 [72].…”

Section: Deactivation Of the Insulin Signaling Pathwaymentioning

confidence: 99%

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Oxidative Stress: Pathogenetic Role in Diabetes Mellitus and Its Complications and Therapeutic Approaches to Correction

2021

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The review presents modern views about the role of oxidative stress reactions in the pathogenesis of types 1 and 2 diabetes mellitus and their complications based on the analysis of experimental and clinical studies. The sources of increased ROS generation in diabetes are specified, including the main pathways of altered glucose metabolism, oxidative damage to pancreatic β-cells, and endothelial dysfunction. The relationship between oxidative stress, carbonyl stress, and inflammation is described. The significance of oxidative stress reactions associated with hyperglycemia is considered in the context of the “metabolic memory” phenomenon. The results of our studies demonstrated significant ethnic and age-related variability of the LPO—antioxidant defense system parameters in patients with diabetes mellitus, which should be considered during complex therapy of the disease. Numerous studies of the effectiveness of antioxidants in diabetes mellitus of both types convincingly proved that antioxidants should be a part of the therapeutic process. Modern therapeutic strategies in the treatment of diabetes mellitus are aimed at developing new methods of personalized antioxidant therapy, including ROS sources targeting combined with new ways of antioxidant delivery.

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Section: Deactivation Of the Insulin Signaling Pathwaymentioning

confidence: 68%

Section: Deactivation Of the Insulin Signaling Pathwaymentioning

confidence: 99%

Section: Deactivation Of the Insulin Signaling Pathwaymentioning

confidence: 99%

Section: Deactivation Of the Insulin Signaling Pathwaymentioning

confidence: 99%

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Oxidative Stress: Pathogenetic Role in Diabetes Mellitus and Its Complications and Therapeutic Approaches to Correction

2021

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“…Numerous studies have demonstrated that reactive oxygen species (ROS), which are mainly generated by the glycation reaction in a variety of tissues, cause chronic oxidative stress in diabetic patients. This oxidative stress may result in various types of tissue damage in diabetic patients [2,3]. Therefore, innovative approaches utilizing both traditional and novel antioxidants need to be used to treat diabetes [4].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Antioxidant and Antidiabetic properties of leaves aqueous extract of Sonchus maritimus

Chetehouna,

Derouiche,

Réggami

2024

Int J Chem Biochem Sci

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One of the most serious health issues facing worldwide today is diabetes mellitus. Although they have inevitable adverse effects, conventional antidiabetic medications are effective. However, plants might also provide an alternate source of anti-diabetic chemicals. This study was focused on determining the antioxidant activities of the leaves aqueous extract of Sonchus maritimus using 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity and ferric reducing ability assay power (FRAP), as well as its antidiabetic activities, which were performed using different protocols, including alpha-amylase inhibitory properties, glucose uptake by yeast cell’s ability, and glucose adsorption capacity. It was noted that S. maritimum extract exhibited moderate activities to scavenge the free radical DPPH and to reduce ferric iron to ferrous iron compared to standard (ascorbic acid). However, the aqueous extract of S. maritimus showed better alpha-amylase inhibitory activity compared to acarbose. It also showed good adsorption strength for binding to glucose molecules. Moreover, the extract showed excellent improvement in glucose uptake by yeast cells at different glucose concentrations in the medium compared to metformin. In conclusion, the aqueous extract of S. maritimus leaves is a promising source of potential antidiabetic compounds that can help prevent diabetes complications and alleviate associated oxidative stress.

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Phytochemical Profile, Antioxidant, Enzyme Inhibition, Acute Toxicity, In Silico Molecular Docking and Dynamic Analysis of Apis Mellifera Propolis as Antidiabetic Supplement

Syaifie,

Ibadillah,

Jauhar

et al. 2024

Chemistry & Biodiversity

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This study aims to identification of phytochemical profile of Apis mellifera propolis and explore potential of its anti‐diabetic activity through inhibition on α‐amylase (α‐AE), α‐glucosidase(α‐GE) and finally identified the novel antidiabetic compounds from propolis. Apis mellifera propolis extract (AMPE) exhibited elevated polyphenol 33.26 ± 0.17 (mg GAE/g) and flavonoid (15.45 ± 0.13 mg RE/g), while its also indicated moderate strong antioxidant activity (EC50 793.09 ±1.94 µg/ml). This study found that AMPE displayed promising α‐AE and α‐GE inhibition through in vitro study. Based on LC‐MS/MS screening, 18 unique AMPE compounds were identified, majorly belonging to anthraquinone and flavonoid compounds. In silico study determined that 8 compounds of AMPE compounds exhibited strong binding to α‐AE, interacting to catalytic residue of ASP197. Moreover, 2 compounds exhibit potential inhibition of α‐AG, by interacting to crucial amino acids of ARG315, ASP352, and ASP69. Finally, we suggested 2,7‐Dihydroxy‐1‐(p‐hydroxybenzyl)‐4‐methoxy‐9,10‐dihydrophenanthrene and 3(3‐(3,4‐Dihydroxybenzyl)‐7‐hydroxychroman‐4‐one as novel inhibitors of α‐AE and α‐GE. Notably, these compounds were initially discovered in Apis mellifera propolis, and molecular dynamic analysis confirmed their stable binding with both enzymes over 100 ns simulations. In vivo acute toxicity test reveals AMPE as a practically non‐toxic product with LD50 value of 16050mg/kg.

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Oxidative stress and antioxidants in diabetes mellitus

Cited by 34 publications

References 3 publications

Oxidative Stress: Pathogenetic Role in Diabetes Mellitus and Its Complications and Therapeutic Approaches to Correction

Oxidative Stress: Pathogenetic Role in Diabetes Mellitus and Its Complications and Therapeutic Approaches to Correction

In Vitro Antioxidant and Antidiabetic properties of leaves aqueous extract of Sonchus maritimus

Phytochemical Profile, Antioxidant, Enzyme Inhibition, Acute Toxicity, In Silico Molecular Docking and Dynamic Analysis of Apis Mellifera Propolis as Antidiabetic Supplement

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