Oxidative Stress and Benefits of Antioxidant Agents in Acute and Chronic Hepatitis

Abstract

ContextOxidative damage due to oxidative stress is the failure of the cell's defense against the deleterious effects of harmful agents by means of its numerous autoprotective mechanisms. oxidative stress is a key impairment induced by various conditions, including atherosclerosis, hypertension, ischemia-reperfusion, hepatitis, pancreatitis, cancer, and neurodegenerative diseases.Evidence AcquisitionOxidative stress is a common pathogenetic mechanism contributing to the initiation and progression of hepatic damage in cases of inflammatory liver disorders, including acute and chronic hepatitis. Antioxidant administration is a good therapeutic strategy for the treatment of hepatitis.ResultsOur comprehensive review of the literature revealed that contradictory results have been obtained with many antioxidants and antioxidant agents.ConclusionSince clinical studies to date have generally involved testing of the effects of antioxidant mixtures containing more than 2 antioxidants and also have been limited because of toxic effects of high doses of some antioxidants, antioxidant therapy for acute and chronic hepatitis needs further study.

Oxidative Stress and Liver Cancer: Etiology and Therapeutic Targets

“…In addition, antioxidant drugs composed of ebselen (glutathione peroxidase analogue) have been used in early liver damage caused by alcohol. Studies have shown that vitamin E inhibits HBV replication and TGF- β gene expression in a rat model of NASH [68, 69]. …”

Glutathione S-Transferase P1 Correlated with Oxidative Stress in Hepatocellular Carcinoma

“…Previous studies have reported that oxidative stress takes part in pathogenesis of both HCC and CHB 5, 6. Bolukbas et al reported that increased oxidative stress was involved in various forms of HBV infection 7.…”

Oxidative stress modulation in hepatitis C virus infected cells

“…However, because the symptoms and pathology of viral diseases are ultimately the result of complex host reactions in addition to direct viral effects, there is a scientific basis for this strategy of viral disease therapy. Clearly, this does not obviate the need for further research to identify a drugs that may specifically interfere with viral replication [40,42,43] . The modulation of major signaling the Nrf2/ARE signaling pathway is triggered at least by five of the HCV viral proteins (core, E1, E2, NS4B, and NS5A).…”

“…Triple antioxidants therapies have been tested in clinical trials, which include alpha-lipoic acid, silymarin and selenium in order to suppress HCV-induced liver damage, when used together with Vitamins C and E, and in a healthy diet and exercise regime [43,75,76] . Several studies are in favor of a positive control of HCV replication by oxidative stress and to search counteracting this effect.…”