Oxidative stress and dietary phytochemicals: Role in cancer chemoprevention and treatment

Chikara, Shireen; Nagaprashantha, Lokesh Dalasanur; Singhal, Jyotsana; Horne, David; Awasthi, Yogesh C.; Singhal, Sharad S.

doi:10.1016/j.canlet.2017.11.002

Cited by 454 publications

(314 citation statements)

References 212 publications

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“…Importantly, many phytochemicals have been shown to suppress cellular signaling pathways and promote cancer cell death. They behave like pro-oxidants, increasing oxidative stress in cancer cells by inhibiting ROS scavenging system, inactivating pro-survival signaling pathways, and finally triggering apoptotic cell death [7]. Bioflavonoids are a large group of bioactive compounds that mediate antitumor effects in many cancer models.…”

Section: Introductionmentioning

confidence: 99%

Antitumor effects of candidone extracted from <i>Derris indica</i> (Lamk) Bennet in cholangiocarcinoma cells

Kurasug¹,

Kukongviriyapan²,

Prawan³

et al. 2018

Trop. J. Pharm Res

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Section: Introductionmentioning

confidence: 99%

Antitumor effects of candidone extracted from <i>Derris indica</i> (Lamk) Bennet in cholangiocarcinoma cells

Kurasug¹,

Kukongviriyapan²,

Prawan³

et al. 2018

Trop. J. Pharm Res

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“…Moreover, ROS activates several molecules and affects multiple cellular processes such as apoptosis, proliferation and gene expression . Oxidative stress can trigger carcinogenesis and damage cells and is significant in tumor expansion . Several toxic agents including inflammatory cytokines, irradiation and chemical oncogens induce ROS formation and thereby change redox potential, and can activate various signaling pathways.…”

Section: The Mechanisms Of Leukemia Pathogenesismentioning

confidence: 99%

Melatonin: A promising agent targeting leukemia

Shafabakhsh

Mirzaei

Asemi

2019

J of Cellular Biochemistry

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Leukemia or cancer of blood is a well‐known cancer, which affects a range of people from newborns to the very old. It is a public health problem throughout the world. By way of treatment, due to the lack of specific anticancer therapies, common treatments of leukemia lead to severe side effects. Nonspecific anticancer drugs result in inhibition of normal cell growth and thereby their necrosis. Moreover, drug resistance is an additional problem, which stands in the way of leukemia treatment. Thus, finding new treatments for leukemia is essential. Melatonin, as a natural product, has been shown to be effective in a wide variety of diseases such as coronary heart disease, schizophrenia, chronic pain, and Alzheimer's disease. In addition, melatonin levels have been observed to be altered in different cancers, such as breast cancer, colorectal cancer endometrial cancer, and hematopoetical cancers. Anticancer features of melatonin such as pro‐oxidation, apoptosis induction, antiangiogenesis property and metastasis and invasion inhibition suggest that this natural compound can be used as a potential agent in novel therapeutic strategies for cancers. Also, it has been reported that melatonin has positive and protective effects on different physiological reactions and in normal bone marrow cells suggesting effectiveness in leukemia therapy. Thus, the aim of our paper was to depict and summarize the main molecular targets of melatonin on leukemia models.

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“…During the promotion stage, oxidation of methionine and cysteine residues in proteins can affect their structure and enzymatic activities that result in deregulation of some signaling pathways, such as RAS‐MEK‐ERK1/2, phosphoinositide 3‐kinase (PI3K)/AKT, Keap1‐Nrf2‐ARE, nuclear factor κB, and JAK/STAT . Toward inactivation of phosphatases by ROS‐mediated oxidation of the reactive cysteine thiol at their catalytic site, they are unable to dephosphorylate, and cannot inactivate target proteins, such as those belonging to RAS‐MEK‐ERK and PI3K/AKT signaling pathways . Thus, elevated levels of ROS by generating genomic instability, contribute to the progression phase of carcinogenesis.…”

Section: Mechanisms Of Os In Cancer: Trace Elements Implicationmentioning

confidence: 99%

“…To limit these toxic effects of ROS in response to OS, various oncogenes also increase the expression of nuclear factor E2‐related factor 2 (Nrf2), which stimulates tumorigenesis and reduces ROS levels . Intracellular ROS reduction is regulated by antioxidant enzymes such as SODs, catalase (CAT), heme oxygenase‐1 (HMOX‐1), glutathione peroxidase (GPx), thioredoxins (TXN), thioredoxin reductase (TRXR), peroxiredoxins (PRDx), NAD(P)H quinone oxidoreductase 1 (NQO1), and glutathione‐ S ‐transferase (GSTs) . The content and activity of enzymatic antioxidants are associated with the concentration of trace elements .…”

Section: Mechanisms Of Os In Cancer: Trace Elements Implicationmentioning

confidence: 99%

The crosstalk between trace elements with DNA damage response, repair, and oxidative stress in cancer

Tehrani

Hosseini

Yousefi

et al. 2018

J of Cellular Biochemistry

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DNA damage response (DDR) is a regulatory system responsible for maintaining genome integrity and stability, which can sense and transduce DNA damage signals. The severity of damage appears to determine DDRs, which can include damage repair, cell‐cycle arrest, and apoptosis. Furthermore, defective components in DNA damage and repair machinery are an underlying cause for the development and progression of various types of cancers. Increasing evidence indicates that there is an association between trace elements and DDR/repair mechanisms. In fact, trace elements seem to affect mediators of DDR. Besides, it has been revealed that oxidative stress (OS) and trace elements are associated with cancer development. In this review, we discuss the role of some critical trace elements in the risk of cancer. In addition, we provide a brief introduction on DDR and OS in cancer. Finally, we will further review the interactions between some important trace elements including selenium, zinc, chromium, cadmium, and arsenic, and DDR, and OS in cancer.

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Oxidative stress and dietary phytochemicals: Role in cancer chemoprevention and treatment

Cited by 454 publications

References 212 publications

Antitumor effects of candidone extracted from <i>Derris indica</i> (Lamk) Bennet in cholangiocarcinoma cells

Antitumor effects of candidone extracted from <i>Derris indica</i> (Lamk) Bennet in cholangiocarcinoma cells

Melatonin: A promising agent targeting leukemia

The crosstalk between trace elements with DNA damage response, repair, and oxidative stress in cancer

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