Oxidative Stress and Genetic Variants of Xenobiotic-Metabolising Enzymes Associated with COPD Development and Severity in Serbian Adults

Malic, Zivka; Topić, Aleksandra; Francuski, Djordje; Stanković, Marija; Nagorni-Obradović, Ljudmila; Marković, Bojan; Radojković, Dragica

doi:10.1080/15412555.2016.1199667

Cited by 9 publications

(3 citation statements)

References 38 publications

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“…By means of these methods, a significant increase or no differences in the levels of DNA damage has been detected in the blood and urine of COPD patients compared to the controls; however, a significant increase has been found in sputum. [25,30,37,43,75,[92][93][94][95][96][97] (Table 2).…”

Section: Total Oxidant Statusmentioning

confidence: 99%

Reliability and Usefulness of Different Biomarkers of Oxidative Stress in Chronic Obstructive Pulmonary Disease

Zinellu

Fois

et al. 2020

Oxidative Medicine and Cellular Longevity

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Introduction. Chronic obstructive pulmonary disease (COPD) is a progressive disease characterized by airflow limitation that is not fully reversible after inhaled bronchodilator use associated with an abnormal inflammatory condition. The biggest risk factor for COPD is cigarette smoking. The exposure to noxious chemicals contained within tobacco smoke is known to cause airway epithelial injury through oxidative stress, which in turn has the ability to elicit an inflammatory response. In fact, the disruption of the delicate balance between oxidant and antioxidant defenses leads to an oxidative burden that has long been held responsible to play a pivotal role in the pathogenesis of COPD. There are currently several biomarkers of oxidative stress in COPD that have been evaluated in a variety of biological samples. The aim of this review is to identify the best studied molecules by summarizing the key literature findings, thus shedding some light on the subject. Methods. We searched for relevant case-control studies examining oxidative stress biomarkers in stable COPD, taking into account the analytical method of detection as an influence factor. Results. Many oxidative stress biomarkers have been evaluated in several biological matrices, mostly in the blood. Some of them consistently differ between the cases and controls even when allowing different analytical methods of detection. Conclusions. The present review provides an overview of the oxidative stress biomarkers that have been evaluated in patients with COPD, bringing focus on those molecules whose reliability has been confirmed by the use of different analytical methods.

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Section: Total Oxidant Statusmentioning

confidence: 99%

Reliability and Usefulness of Different Biomarkers of Oxidative Stress in Chronic Obstructive Pulmonary Disease

Zinellu

Fois

et al. 2020

Oxidative Medicine and Cellular Longevity

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“…In vitro studies, tyrosine at codon 113 in exon 3 was replaced by histidine (Tyr113His), which reduced the enzyme activity by > 50%, and the mutant is referred as the “slow” allele. Histidine at codon 139 in exon 4 was replaced by arginine (His139Arg), which increased the enzyme activity by more than 25%, and is referred as the “fast” allele [ 18 ]. In this meta-analysis, the “slow” allele was significantly associated with increased COPD risk, and the “fast” allele with decreased COPD risk.…”

Section: Discussionmentioning

confidence: 99%

Association between the oxidative stress gene polymorphism and chronic obstructive pulmonary disease risk: a meta-analysis

Zhou,

Zuo,

Chen

et al. 2023

BMC Pulm Med

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Background The association between the oxidative stress gene polymorphism and chronic obstructive pulmonary disease (COPD) risk has been extensively studied but the results have been controversial. This study aimed to investigate the overall association between the oxidative stress gene including glutathione S-transferase (GST), epoxide hydrolase exon (EPHX), superoxide dismutase (SOD), catalase (CAT), cytochrome P450 system (CYP) and heme oxygenase (HO-1) polymorphism and the risk of COPD. Methods We searched the PubMed and EMBASE database to identify studies that investigated the association between the oxidative stress gene polymorphism and risk of COPD. The relevant data were extracted and statistical analyses were performed using the Revman 5.4 and STATA 12 software. Dominant genetic model, recessive model, co-dominant model, heterozygote model, and allele model were analyzed. Venice criteria and publication bias were conducted to access the credibility and reliability. Results In total, 63 publications including 14,733 patients and 50,570 controls were included in the meta-analysis.15 genetic variants of 6 genes were analyzed, and 7 SNPs in GSTP1, CAT, CYP, SOD were first analyses until now. In our study, EPHX T113C C allele, GSTM1 null, GSTT1 null, GSTP1 A313G G and C341T T allele, CYP1A1 MspI C allele, SOD3 A213G G allele and L type in Ho-1 showed increased COPD risk, especially in Asians. T allele in CAT C262T and C allele in SOD2 Val 9 Ala were associated with decreased COPD risk. To avoid high heterogeneity and publications bias, subgroups analysis was performed in accord with HWE and ethnicity. Publication bias was assessed by Begg’s funnel plots and Egger’s test, and no publication bias were found for recessive models. 4 variants were identified with strong levels of epidemiological evidence of associations with the COPD risk. Conclusions Our results confirm that oxidative stress gene polymorphism was associated with COPD risk. These finding can improve human understanding of this disease gene molecular level and enable early intervention and prevention of COPD. Well-designed studies with large sample sizes are essential to clarify the association of these significant variants with the susceptibility to COPD.

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“…Size of the organ, and extent of the oxidative stress in that organ, will be among the factors influencing whether localized oxidative stress impacts systemic measures. This is demonstrated in many studies in the literature, for example the presence of chronic lung inflammation (e.g., chronic obstructive pulmonary disease, COPD) has been found to significantly increase the urinary levels of oxidative stress biomarkers up to two times [ 241 , 286 ], and critically ill patients on mechanical ventilation in intensive care units have approximately three times higher levels of oxidised nucleic acids products in urine, compared to COPD patients [ 241 ].…”

Section: Perspectives On the Interpretation Of Biomarkers Of Oxidatively Generated Damage To Nucleic Acids In Surrogate Tissues Or Biologmentioning

confidence: 99%

Biomarkers of nucleic acid oxidation – A summary state-of-the-art

Chao

Evans

et al. 2021

Redox Biology

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Oxidatively generated damage to DNA has been implicated in the pathogenesis of a wide variety of diseases. Increasingly, interest is also focusing upon the effects of damage to the other nucleic acids, RNA and the (2′-deoxy-)ribonucleotide pools, and evidence is growing that these too may have an important role in disease. LC-MS/MS has the ability to provide absolute quantification of specific biomarkers, such as 8-oxo-7,8-dihydro-2′-deoxyGuo (8-oxodG), in both nuclear and mitochondrial DNA, and 8-oxoGuo in RNA. However, significant quantities of tissue are needed, limiting its use in human biomonitoring studies. In contrast, the comet assay requires much less material, and as little as 5 μL of blood may be used, offering a minimally invasive means of assessing oxidative stress in vivo , but this is restricted to nuclear DNA damage only. Urine is an ideal matrix in which to non-invasively study nucleic acid-derived biomarkers of oxidative stress, and considerable progress has been made towards robustly validating these measurements, not least through the efforts of the European Standards Committee on Urinary (DNA) Lesion Analysis. For urine, LC-MS/MS is considered the gold standard approach, and although there have been improvements to the ELISA methodology, this is largely limited to 8-oxodG. Emerging DNA adductomics approaches, which either comprehensively assess the totality of adducts in DNA, or map DNA damage across the nuclear and mitochondrial genomes, offer the potential to considerably advance our understanding of the mechanistic role of oxidatively damaged nucleic acids in disease.

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Oxidative Stress and Genetic Variants of Xenobiotic-Metabolising Enzymes Associated with COPD Development and Severity in Serbian Adults

Cited by 9 publications

References 38 publications

Reliability and Usefulness of Different Biomarkers of Oxidative Stress in Chronic Obstructive Pulmonary Disease

Reliability and Usefulness of Different Biomarkers of Oxidative Stress in Chronic Obstructive Pulmonary Disease

Association between the oxidative stress gene polymorphism and chronic obstructive pulmonary disease risk: a meta-analysis

Biomarkers of nucleic acid oxidation – A summary state-of-the-art

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