Oxidative stress and genotoxicity in oral epithelial cells from subjects undergoing orthodontic treatment with fixed appliances

Angeles-Estrada, Lucía; Pérez-Soto, Elvia; Pérez-Vielma, Nadia Mabel; Gómez-López, Modesto; Sánchez-Monroy, Virginia

doi:10.1007/s00784-023-05039-6

Cited by 3 publications

(3 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Buczko et al [ 45 ] observed significant increases in salivary markers such as tiobarbituric acid reactive substances and total oxidant status shortly after appliance placement, with tiobarbituric acid reactive substances rising one week post-treatment and total protein concentration increasing significantly at twenty-four weeks. On the other hand, Angeles-Estrada et al [ 46 ] reported increases in the oxidative stress marker 8-hydroxy-2′deoxyguanosine and significant changes in antioxidant enzymes, with superoxide dismutase levels increasing by 2.5 times after six months and catalase tripling after six months, then returning to baseline by nine months.…”

Section: Discussionmentioning

confidence: 99%

Evaluating the Therapeutic Properties of Natural Products in Orthodontic and Surgical Treatment of Dentofacial Deformities: A Systematic Review of Clinical Trials

Talpos Niculescu,

Avramut,

Hajaj

et al. 2024

Nutrients

View full text Add to dashboard Cite

The use of natural products as alternatives to traditional pharmacological treatments in orthodontics is gaining interest due to their anti-inflammatory, antibacterial, and antioxidant properties. This systematic review synthesizes evidence from clinical trials to evaluate the efficacy of natural products in reducing inflammation and bacterial presence in orthodontic and orthognathic treatment settings. The database search was conducted across PubMed, Scopus, and Embase up to January 2024. The review focused on randomized controlled trials only. The selected studies centered on the anti-inflammatory, antibacterial, and antioxidant effects of natural products, adhering to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines for data extraction. Nine studies, totaling 358 participants, were included. Significant findings demonstrated a reduction in gingival inflammation by over 40% with the use of Aloe vera compared to chlorhexidine. Another study noted a decrease in bleeding on probing by 13.6 points in the treatment group over placebo. Additionally, honey showed a rapid modulation of plaque pH and significantly reduced bacterial counts of Streptococcus mutans. Furthermore, the use of resveratrol emulgel was linked to substantial improvements in gingival health, with a reduction in the gingival index and probing pocket depth. The results indicate that natural products can significantly enhance orthodontic treatment outcomes by reducing inflammation and bacterial levels. These products offer effective alternatives to traditional treatments and show potential for integration into routine orthodontic care protocols. Further research is encouraged to standardize application methods and dosages to maximize clinical benefits and patient satisfaction.

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluating the Therapeutic Properties of Natural Products in Orthodontic and Surgical Treatment of Dentofacial Deformities: A Systematic Review of Clinical Trials

Talpos Niculescu,

Avramut,

Hajaj

et al. 2024

Nutrients

View full text Add to dashboard Cite

show abstract

“…The data suggest a biological adaptation response to orthodontic treatment that occurs after approximately 6 months, as indicated by alterations in antioxidant enzyme expression and DNA degradation and instability. This study contributes to the understanding of the effects of orthodontic treatment on oral health and underscores the importance of long-term investigations to comprehensively assess DNA damage induced by fixed orthodontic appliances [ 73 ].…”

Section: Discussionmentioning

confidence: 99%

“… Robins tool to evaluate bias [ 17 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 ]. …”

Section: Figureunclassified

Oxidative Stress and Natural Products in Orthodontic Treatment: A Systematic Review

Inchingolo,

Latini

et al. 2023

Nutrients

View full text Add to dashboard Cite

In recent years, orthodontics, a specialized branch of dentistry, has evolved considerably in terms of both techniques and materials used. Aimed at correcting dental malocclusions and craniofacial anomalies, it improves the functionality and aesthetics of the face and oral cavity. However, orthodontic treatment, in its developmental stages, may induce oxidative stress (O.S.) phenomena, with an increase in the production of reactive oxygen species (ROS), damaging the dental and periodontal tissues involved, affecting the short-, medium- and long-term results. Studies on the antioxidant effects of natural products (e.g., resveratrol, green tea, turmeric, etc.) in the medical field have aroused considerable interest in recent years. A systematic literature review was conducted on the PubMed, Scopus, and Web of Science databases using natural products (N.P.s), O.S., and orthodontic as keywords. The study aims to consider the determinants of the increase in ROS occurring during orthodontic treatment and the possibility of natural products being able to control and neutralize biochemical phenomena by restoring the physiological process in which the balance between the production of ROS and the ability of the body’s antioxidant system to neutralize them is in favor of the latter.

show abstract

Metal ion release from orthodontic appliances: Concerns regarding potential carcinogenic effects

Suryawanshi,

Hande,

Dasari

et al. 2024

Oral Oncology Reports

View full text Add to dashboard Cite

Oxidative stress and genotoxicity in oral epithelial cells from subjects undergoing orthodontic treatment with fixed appliances

Cited by 3 publications

References 38 publications

Evaluating the Therapeutic Properties of Natural Products in Orthodontic and Surgical Treatment of Dentofacial Deformities: A Systematic Review of Clinical Trials

Evaluating the Therapeutic Properties of Natural Products in Orthodontic and Surgical Treatment of Dentofacial Deformities: A Systematic Review of Clinical Trials

Oxidative Stress and Natural Products in Orthodontic Treatment: A Systematic Review

Metal ion release from orthodontic appliances: Concerns regarding potential carcinogenic effects

Contact Info

Product

Resources

About