Oxidative Stress and Gut Microbiome in Inflammatory Skin Diseases

Ni, Qingrong; Zhang, Ping; Li, Qiang; Han, Zheyi

doi:10.3389/fcell.2022.849985

Cited by 20 publications

(17 citation statements)

References 172 publications

(197 reference statements)

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“…Taken together, these results provide some indications for a close interaction between oxidative status and skin microbiome composition [13].…”

Section: Introductionsupporting

confidence: 53%

Skin Beautification with an ImmunatuRNA® Complex: A Natural Complex Based on Yeast RNA and Marine Derivatives on the Human Skin Immunity and Microbiome Composition

Neymann¹

2023

J Immuno Allerg

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The skin is the largest organ of human body implicated in vital physiological and immunological processes, including protection against injury, infections, and environmental exposures. Nevertheless, a number of negative external and internal factors, including increased pollution along with modern lifestyle can significantly influence on the skin immunity, promote aging and reduce regenerative capabilities. Cosmetic formulations based on natural ingredients, including plant and marine/algae extracts, and microbial-derived bio-actives may help to maintain healthy skin condition and protect its beautiful appearance. The ImmunatuRNA®* (*The trademark ImmunatuRNA® is a registered trademark in the European Union EUTM 018365297 and Great Britain UK00003630172. Any reference to the registration of the ImmunatuRNA® trademark applies to the designated territories), a signature complex (VRFD SA/VERDILAB Switzerland) based on the Natural RNA molecules obtained from yeasts, with added marine exopolysaccharides and natural hyaluronic acid with potential benefits for antibacterial and antiradical defense and maintaining skin detox homeostasis. Therefore, the main aim of this study is to experimentally assess the ImmunatuRNA® complex capabilities to enhance natural skin antioxidant defenses and protection against oxidative stress, by using human fibroblast cell culture. Additionally, this study will investigate the effects of the skincare products with added ImmunatuRNA® complex on the skin microbiome composition in the group of healthy adults with various skin types. The results obtained from the in vitro studies consistently demonstrated that treatment with an ImmunatuRNA® complex protects human fibroblasts against exposure to pro-oxidants, while at the same time enhances anti-oxidative defenses of these cells, demonstrated as reduced formation of free radicals and upregulation of SIRT-1 protein. Furthermore, the cosmetic intervention carried on the group of 10 healthy human volunteers with different skin types (oily, dry, combined, normal) aged between 23 and 65 years old demonstrated that using interchangeably of two cosmetic products-a Natural Moisturizer Probiotic Cream and Natural Detox Replenishing Face Mask containing the ImmunatuRNA® complex, for 4-weeks led to favorable changes in the composition of skin microbiome observed as a reduction of relative abundance of adverse microorganisms, previously linked to the skin inflammation and infections, such as Citrobacter koseri, Bacillus spp., Enterococcus spp., Alcaligenes spp., Pantoea spp. and Staphylococcus aureus. Based on following results, the use of skincare products containing the ImmunatuRNA® complex can help maintain a healthy skin microbiome while possibly preventing against infections and negative environmental exposures, in particularly against oxidative stress in healthy adults with all types of skin with age range 23-65 years old.

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“…Taken together, these results provide some indications for a close interaction between oxidative status and skin microbiome composition [13].…”

Section: Introductionsupporting

confidence: 53%

Skin Beautification with an ImmunatuRNA® Complex: A Natural Complex Based on Yeast RNA and Marine Derivatives on the Human Skin Immunity and Microbiome Composition

Neymann¹

2023

J Immuno Allerg

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“…In this scenario, the presence of reactive species, mainly reactive oxygen species (ROS), reactive nitrogen species (RNS) and reactive sulphur species (RSS), is elevated and may induce DNA damage and cell death. 29 Consequently, these effects negatively impact skin inflammation. The overproduction of ROS plays a crucial role in the pathogenesis of AD, psoriasis and vitiligo.…”

Section: Antioxidant and Anti-inflammatory Propertiesmentioning

confidence: 99%

“…Oxidative stress is a key feature in inflammatory skin conditions correlated with dysbiosis. In this scenario, the presence of reactive species, mainly reactive oxygen species (ROS), reactive nitrogen species (RNS) and reactive sulphur species (RSS), is elevated and may induce DNA damage and cell death 29 . Consequently, these effects negatively impact skin inflammation.…”

Section: Symptomsmentioning

confidence: 99%

Therapeutic textiles: A promising approach for human skin dysbiosis?

de Oliveira,

Tavaria

2024

Experimental Dermatology

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The close interaction between skin and clothing has become an attractive cornerstone for the development of therapeutic textiles able to alleviate skin disorders, namely those correlated to microbiota dysregulation. Skin microbiota imbalance is known in several skin diseases, including atopic dermatitis (AD), psoriasis, seborrheic dermatitis, rosacea, acne and hidradenitis suppurative (HS). Such microbiota dysregulation is usually correlated with inflammation, discomfort and pruritus. Although conventional treatments, that is, the administration of steroids and antibiotics, have shown some efficacy in treating and alleviating these symptoms, there are still disadvantages that need to be overcome. These include their long‐term usage with side effects negatively impacting resident microbiota members, antibiotic resistance and the elevated rate of recurrence. Remarkably, therapeutic textiles as a non‐pharmacological measure have emerged as a promising strategy to treat, alleviate the symptoms and control the severity of many skin diseases. This systematic review showcases for the first time the effects of therapeutic textiles on patients with skin dysbiosis, focusing on efficacy, safety, adverse effects and antimicrobial, antioxidant and anti‐inflammatory properties. The main inclusion criteria were clinical trials performed in patients with skin dysbiosis who received treatment involving the use of therapeutic textiles. Although there are promising outcomes regarding clinical parameters, safety and adverse effects, there is still a lack of information about the impact of therapeutic textiles on the skin microbiota of such patients. Intensive investigation and corroboration with clinical trials are needed to strengthen, define and drive the real benefit and the ideal biomedical application of therapeutic textiles.

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“…ROS can exacerbate inflammatory skin diseases. For instance, they play a crucial role in the pathogenesis of atopic dermatitis (AD), psoriasis, and vitiligo [ 121 ].…”

Section: Microbiota and Oxidative Stressmentioning

confidence: 99%

Microbiota, Oxidative Stress, and Skin Cancer: An Unexpected Triangle

et al. 2023

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Mounting evidence indicates that the microbiota, the unique combination of micro-organisms residing in a specific environment, plays an essential role in the development of a wide range of human diseases, including skin cancer. Moreover, a persistent imbalance of microbial community, named dysbiosis, can also be associated with oxidative stress, a well-known emerging force involved in the pathogenesis of several human diseases, including cutaneous malignancies. Although their interplay has been somewhat suggested, the connection between microbiota, oxidative stress, and skin cancer is a largely unexplored field. In the present review, we discuss the current knowledge on these topics, suggesting potential therapeutic strategies.

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Oxidative Stress and Gut Microbiome in Inflammatory Skin Diseases

Cited by 20 publications

References 172 publications

Skin Beautification with an ImmunatuRNA® Complex: A Natural Complex Based on Yeast RNA and Marine Derivatives on the Human Skin Immunity and Microbiome Composition

Skin Beautification with an ImmunatuRNA® Complex: A Natural Complex Based on Yeast RNA and Marine Derivatives on the Human Skin Immunity and Microbiome Composition

Therapeutic textiles: A promising approach for human skin dysbiosis?

Microbiota, Oxidative Stress, and Skin Cancer: An Unexpected Triangle

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