Oxidative stress and immunological alteration in women with preeclampsia

Silva, Danilla Michelle Costa e; Marreiro, Dilina do Nascimento; Neto, José Machado Moita; Brito, José Araújo; Neta, Eunice Alves da Silva; Matias, Juliana Paz; Sampaio, Fabiane Araújo; Nogueira, Nadir do Nascimento

doi:10.3109/10641955.2013.806540

Cited by 25 publications

(15 citation statements)

References 35 publications

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“…From these findings, it is clear their involvement in the pathophysiology of the disease and that their levels increase according to the severity of PE. In addition, experimental studies [40, 62, 63] also show an increase in levels of inflammatory factors in PE, which is associated with endothelial dysfunction, also observed, as well as the protective role of IL-10, when administered in an appropriate dose/time [64, 65].…”

Section: Pe Vs Inflammatory Biomarkersmentioning

confidence: 99%

Cross-Talk between Oxidative Stress and Inflammation in Preeclampsia

Tenório

Ferreira

Moura

et al. 2019

Oxidative Medicine and Cellular Longevity

163

118

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The occurrence of hypertensive syndromes during pregnancy leads to high rates of maternal-fetal morbidity and mortality. Amongst them, preeclampsia (PE) is one of the most common. This review aims to describe the relationship between oxidative stress and inflammation in PE, aiming to reinforce its importance in the context of the disease and to discuss perspectives on clinical and nutritional treatment, in this line of research. Despite the still incomplete understanding of the pathophysiology of PE, it is well accepted that there are placental changes in pregnancy, associated with an imbalance between the production of reactive oxygen species and the antioxidant defence system, characterizing the placental oxidative stress that leads to an increase in the production of proinflammatory cytokines. Hence, a generalized inflammatory process occurs, besides the presence of progressive vascular endothelial damage, leading to the dysfunction of the placenta. There is no consensus in the literature on the best strategies for prevention and treatment of the disease, especially for the control of oxidative stress and inflammation. In view of the above, it is evident the important connection between oxidative stress and inflammatory process in the pathogenesis of PE, being that this disease is capable of causing serious implications on both maternal and fetal health. Reports on the use of anti-inflammatory and antioxidant compounds are analysed and still considered controversial. As such, the field is open for new basic and clinical research, aiming the development of innovative therapeutic approaches to prevent and to treat PE.

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Section: Pe Vs Inflammatory Biomarkersmentioning

confidence: 99%

Cross-Talk between Oxidative Stress and Inflammation in Preeclampsia

Tenório

Ferreira

Moura

et al. 2019

Oxidative Medicine and Cellular Longevity

163

118

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“…We found no differences in CRP concentrations with end-organ complications. Others have shown both increased CRP concentrations and no difference in severe preeclampsia, but these studies included severe hypertension and other symptoms as severe features and not end-organ complications (15,(18)(19)(20)(21)(22)(23).…”

Section: Results In Contextmentioning

confidence: 99%

Circulating concentrations of pro-inflammatory cytokines in preeclampsia with varying disease severity

Palm

Cluver

Langenegger

et al. 2023

Preprint

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Background Preeclampsia affects about 5% of pregnancies and is diagnosed by new onset of hypertension with end-organ dysfunction. It is hypothesized that systemic inflammation causes maternal vascular endothelial dysfunction and vascular injury. Objective To assess whether plasma concentrations of the circulating inflammatory proteins Interleukin-6 (IL-6), Vascular Cell Adhesion Molecule-1 (VCAM-1) and C-Reactive Protein (CRP) are increased in women with preeclampsia with end-organ complications (severe disease with high morbidity), compared with women with preeclampsia without end-organ complications (hypertension and excessive proteinuria only). Study Design We used samples from a large prospective biobank collection (Preeclampsia Obstetric Adverse Event biobank), and two large, randomized preeclampsia therapeutic treatment trials. All samples were collected in Cape Town, South Africa. The last plasma sample collected prior to birth was analyzed for IL-6, VCAM-1 and CRP concentrations. We categorized cases according to disease severity and compared circulating levels of these analytes. Covariate adjustment was performed for maternal age, body mass index, gestational age and time from sampling to delivery as covariates. Results Of 183 women we included, 119 had preeclampsia without end-organ complications. The remaining 64 had preeclampsia with severe features: 49 had one end-organ complication and 15 had multiple end-organ complications. Compared with women without end-organ complications, those with preeclampsia with multiple end-organ complications had a 4.9-fold (95% CI, 1.81–13.09, p=0.001) increase in IL-6 and a 1.7-fold (95% CI, 1.11–2.72, p=0.012) increase in VCAM-1 plasma concentrations. Comparing women with multiple end-organ complications to those with one end-organ complication, plasma concentrations of IL-6 were 3.2-fold (95% CI, 1.18–8.39, p=0.018) increased, while there was no statistically significant difference for VCAM-1 (1.2-fold higher, 95% CI, 0.79-1.91, p=0.50). Plasma concentrations of CRP did not differ between the groups. Conclusion Plasma concentrations of IL-6 and VCAM-1, but not CRP, were increased among women with preeclampsia and end-organ complications, compared with women without end-organ complications. IL-6 and VCAM-1 could be drivers of disease in preeclampsia and potentially useful to identify women at high risk of severe disease.

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“…But, the largest significant difference was verify between 11 and 16 days after emergence, where all the treatments with physical protector, independently of the filter, originate superior values when compared to the one observed in the absence of the physical protector, being equal at 115, 107 and 100% for the blue protector (BLUE), transparent protector (TRANSP), and red protector (RED), respectively. This way, the higher seedlings emergence may have occur because of the increase of the temperature and phytochrome influence, probably because, the physical protectors may have allowed the canafistula seeds a higher period of time in the optimal temperature for germination, that would explain the maximal germination percentage in a very short time (Silva et al, 2004).…”

Section: Resultsmentioning

confidence: 99%

Influence of physical protectors with different filters on the initial development of Peltophorum dubium (Spreng.) Taub seedlings

Klein¹,

Rodrigues²,

Guimarães³

et al. 2014

Afr. J. Agric. Res.

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The use of physical protectors has been considered as an efficient technique for tillage farming of different species, mainly native ones. Based on the importance of the species, Peltophorum dubium for revegetation of degraded areas, this study evaluated the emergence, survival and initial development of P. dubium seedlings under the influence of physical protectors with different filters. Thus, the following treatments were adopted: absence of physical protector (APP), transparent physical protector (TPP), transparent physical protector + blue cellophane (BPP) and transparent physical protector + red cellophane (RPP). The evaluated characteristics were: emergence velocity index (EVI), seedling survival and emergence percentage, plant height, leaf area and root collar diameter. All of these physical protectors increased the mean values of EVI and survival. In conclusion, the emergence speed and initial development of P. dubium (Spreng.) seedlings grown in the interior of physical protectors, independent on the filters, presented positive results. The reduction on the light intensity interferes positively in the initial growth of these plants.

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Oxidative stress and immunological alteration in women with preeclampsia

Abstract: The MDA is a nonspecific marker for oxidative stress in preeclampsia, and the gestantes with preeclampsia have immune dysfunction.

Cited by 25 publications

References 35 publications

Cross-Talk between Oxidative Stress and Inflammation in Preeclampsia

Cross-Talk between Oxidative Stress and Inflammation in Preeclampsia

Circulating concentrations of pro-inflammatory cytokines in preeclampsia with varying disease severity

Influence of physical protectors with different filters on the initial development of Peltophorum dubium (Spreng.) Taub seedlings

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