Oxidative stress and inflammation are associated with physical frailty in patients with Alzheimer's disease

Namioka, Nayuta; Hanyu, Haruo; Hirose, Daisuke; Hatanaka, Hirokuni; Sato, Toshio; Shimizu, Soichiro

doi:10.1111/ggi.12804

Cited by 72 publications

(52 citation statements)

References 31 publications

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“…After excluding 1221 manuscripts through title/abstract screening, 29 full-text articles were examined and 8 studies (14,15,(20)(21)(22)(23)(24)(25) were included in this systematic review (Figure 1). …”

Section: Resultsmentioning

confidence: 99%

“…The derivate of reactive oxygen metabolites (d-ROM) was evaluated in two studies, d-ROM levels were higher in frail/prefrail compare the robust elderly groups (p<0.01) (14,25). Furthermore, levels of isoprostanes were increased in both frail and pre-frail elders in other two studies (p<0.05) (21,25).…”

Section: -Hydroxy-20-deoxyguanosine Derivate Of Reactive Oxygen Metmentioning

confidence: 98%

“…The 8 studies (14,15,(20)(21)(22)(23)(24)(25) included a total of 6,349 participants with a mean age of 75±12 years and mainly women (=56.4%). Overall, there were 588 (=9.3%) frail, 3,036 pre-frail (=47.8%) and 2,685 (=42.3%) robust, and 40 (=0.6%) pre-frail/robust subjects.…”

Section: Study and Participant Characteristicsmentioning

confidence: 99%

“…As shown in Table 2, seven studies (14,15,21,(22)(23)(24)(25) reported data for peripheral OS biomarkers. Only one study did not find any significant difference between frail and robust groups regarding paraoxonase-1 (PON-1) and Malonaldehyde (MDA) levels (p>0.05) (22), but another study found higher MDA levels among frail elders (p<0.01) (24).…”

Section: Association Between Os Biomarkers and Frailtymentioning

confidence: 99%

“…Only one study did not find any significant difference between frail and robust groups regarding paraoxonase-1 (PON-1) and Malonaldehyde (MDA) levels (p>0.05) (22), but another study found higher MDA levels among frail elders (p<0.01) (24). All included studies, except one (22), reported that higher OS biomarkers were significantly associated with frailty (14,15,21,(23)(24)(25). Oxidative stress biomarkers assayed across studies included lipoprotein phospholipase A2 (LpPLA2), isoprostanes, MDA, 4-hydroxy-2,3-nonenal (HNE),…”

Section: Association Between Os Biomarkers and Frailtymentioning

confidence: 99%

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Oxidative stress and frailty: A systematic review and synthesis of the best evidence

et al. 2017

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Highlights There is a lack of clarity around the relationship between oxidative stress and frailty.  Our review provides some cross sectional evidence of increased oxidative stress among frail older people.  There is some preliminary evidence of lower anti-oxidant parameters (vitamin C, E, α-tocopherol, biological anti-oxidant potential, total thiol levels) in frailty. ABSTRACT (250/250)Objective: Oxidative stress (OS) is associated with accelerated aging. Previous studies have suggested a possible relationship between OS and frailty but this association remains unclear.We conducted a systematic review to investigate potential interactions between OS and frailty.Methods: A systematic literature search of original reports providing data on 'OS and antioxidant' parameters and frailty was carried out across major electronic databases from inception until May 2016. Cross-sectional/case control and longitudinal studies reporting data on the association between frailty and anti-oxidants-OS biomarkers were considered for inclusion. Results were summarized with a best-evidence based synthesis.Results: From 1,856 hits, 8 studies (cross-sectional/case control) were included (N=6,349; mean age of 75±12 years; 56.4% females). Overall, there were 588 (=9.3%) frail, 3,036 prefrail (=47.8%), 40 (=0.6%) pre-frail/robust, and 2,685 (=42.3%) robust subjects. Six crosssectional/case control studies demonstrated that frailty was associated with an increase in peripheral OS biomarkers including lipoprotein phospholipase A2 (studies=1), isoprostanes (studies=2), Malonaldehyde (studies=2), 8-hydroxy-20-deoxyguanosine (studies=2), derivate of reactive oxygen metabolites (studies=2), oxidized Glutathione/ Glutathione (studies=1), 4-hydroxy-2,3-nonenal (studies=1), and protein carbonylation levels (study=1). In addition, preliminary evidence points to lower anti-oxidant parameters (vitamin C, E, α-tocopherol, biological anti-oxidant potential, total thiol levels) in frailty. Conclusion:Frailty and pre-frailty appear to be associated with higher OS and possibly lower anti-oxidant parameters. However, due to the cross sectional design, it is not possible to disentangle the directionality of the relationships observed. Thus, future high quality and in particular longitudinal research is required to confirm/refute these relationships and to further elucidate pathophysiological mechanisms.

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Section: Resultsmentioning

confidence: 99%

Section: -Hydroxy-20-deoxyguanosine Derivate Of Reactive Oxygen Metmentioning

confidence: 98%

Section: Study and Participant Characteristicsmentioning

confidence: 99%

Section: Association Between Os Biomarkers and Frailtymentioning

confidence: 99%

Section: Association Between Os Biomarkers and Frailtymentioning

confidence: 99%

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Oxidative stress and frailty: A systematic review and synthesis of the best evidence

et al. 2017

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Sustained frailty remission and dementia risk in older adults: A longitudinal study

Wang,

Li,

Wang

et al. 2024

Alzheimer's & Dementia

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INTRODUCTIONPhysical frailty is reversible, but little is known about the sustainability of frailty remission and its impact on dementia.METHODSData were derived from the National Health and Aging Trends Study (NHATS) (2011 to 2021). Physical frailty was assessed using the Fried frailty phenotype, and frailty transition patterns across three waves were defined. The relationship of sustained frailty remission with incident dementia was examined using Cox proportional regression, stratified by age and gender.RESULTSAmong 1931 participants, 348 (18.0%) were capable of sustained frailty remission. During the 8‐year follow‐up, 279 participants developed dementia. In a fully adjusted model, sustained remission was associated with a lower risk of dementia (hazard ratio = 0.66, 95% confidence interval = 0.47 to 0.93). The association was more pronounced among younger‐old and male participants but not observed among their counterparts.DISCUSSIONSustained frailty remission was associated with a reduced risk of developing dementia. Physical frailty could be an essential forewarning of dementia and a target for interventions.Highlights We provided new insights into the natural progression of frailty and its impact on dementia risk using a nationally representative sample Sustained frailty remission reduced risk of incident dementia. Age and gender played a role in the frailty‐dementia link, and thus individualized dementia risk screening is necessary. Physical frailty could be an essential forewarning of cognitive decline and an ideal target for interventions to prevent dementia.

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Oxidative Stress, Frailty and Cardiovascular Diseases: Current Evidence

Uchmanowicz

2020

Advances in Experimental Medicine and Biology

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Oxidative stress and inflammation are associated with physical frailty in patients with Alzheimer's disease

Abstract: Physical frailty is common in old and female AD patients with comorbid medical diseases. The present results strongly suggest that oxidative stress and inflammation are involved in the pathophysiology of frailty status in individuals with AD. Geriatr Gerontol Int 2017; 17: 913-918.

Cited by 72 publications

References 31 publications

Oxidative stress and frailty: A systematic review and synthesis of the best evidence

Oxidative stress and frailty: A systematic review and synthesis of the best evidence

Sustained frailty remission and dementia risk in older adults: A longitudinal study

Oxidative Stress, Frailty and Cardiovascular Diseases: Current Evidence

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