Oxidative Stress and Inflammation as Targets for Novel Preventive and Therapeutic Approaches in Non-Communicable Diseases II

Nediani, Chiara; Dinu, Monica

doi:10.3390/antiox11050824

Cited by 10 publications

(5 citation statements)

References 23 publications

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“…The inflammatory milieu can affect nutritional status in several ways. TNFα promotes a catabolic state by inducing anorexia and engendering both protein degradation and suppression of their synthesis [ 27 , 28 , 29 ]. Therefore, uremic patients with a higher inflammatory state are prone to develop a negative protein balance because of a shift from anabolic protein synthesis to acute-phase protein production [ 29 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

In Patients with Chronic Kidney Disease Advanced Glycation End-Products Receptors Isoforms (sRAGE and esRAGE) Are Associated with Malnutrition

et al. 2022

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Background: in patients with chronic kidney disease (CKD), the inflammatory and pro-oxidant milieu may contribute to malnutrition development. In this study, we investigated the relationship between inflammation, advanced glycation end-products (AGEs), and their receptors (RAGEs) with malnutrition in CKD patients. Methods: we evaluated 117 patients. AGEs were quantified by fluorescence intensity using a fluorescence spectrophotometer, soluble RAGEs isoforms, and inflammatory interleukins by ELISA. Malnutrition was assessed by a malnutrition inflammation score. Results: mean age was 80 ± +11 years, eGFR was 25 ± +11 mL/min/1.73 m2 and BMI was 28 ± 5 Kg/m2. Malnourished individuals were older, had lower estimated protein intake (nPCR 0.65 ± 0.2 vs. 0.8 ± 0.2 vs. 0.8 ± 0.3, p = 0.01), higher C reactive protein (CRP 0.6 ± 1 vs. 0.6 ± 0.7 vs. 0.17 ± 0.13, p = 0.02) and tumor necrosis factor α (TNF α 14.7 ± 8.7 vs. 15.6 ± 8 vs. 11.8 ± 5.8, p = 0.029). Malnourished patients had higher sRAGE (2813 ± 1477 vs. 2158 ± 1236 vs. 2314 ± 1115, p = 0.035) and esRAGE (648 [408–1049] vs. 476 [355–680] vs. 545 [380–730] p = 0.033). In the multivariate analysis, only sRAGE maintained its association with malnutrition (p = 0.02) independently of aging and inflammation. Conclusions: in CKD patients, RAGEs isoforms, but not AGEs, are associated with malnutrition, irrespective of systemic inflammation, aging, and renal function.

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Section: Discussionmentioning

confidence: 99%

In Patients with Chronic Kidney Disease Advanced Glycation End-Products Receptors Isoforms (sRAGE and esRAGE) Are Associated with Malnutrition

et al. 2022

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“…Evidence has demonstrated that reactive oxygen species (ROS) constitute the link between chronic inflammation and neoplasia. Initial experiments on the role of ROS in tumor initiation indicated that oxidative stress directly damages DNA, promoting mutations that favor oncogenic transformation [ 16 , 17 ].…”

Section: Etiology and Epidemiologymentioning

confidence: 99%

Diagnosis, Prognosis, and Treatment of Canine Hemangiosarcoma: A Review Based on a Consensus Organized by the Brazilian Association of Veterinary Oncology, ABROVET

Nardi

Massoco

Fonseca-Alves

et al. 2023

Cancers

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Hemangiosarcoma is a mesenchymal neoplasm originating in the endothelial cells of blood vessels; they can be classified as non-visceral and visceral types. Non-visceral hemangiosarcomas can affect the skin, subcutaneous tissues, and muscle tissues; visceral hemangiosarcomas can affect the spleen, liver, heart, lungs, kidneys, oral cavity, bones, bladder, uterus, tongue, and retroperitoneum. Among domestic species, dogs are most affected by cutaneous HSA. Cutaneous HSA represents approximately 14% of all HSA diagnosed in this species and less than 5% of dermal tumors, according to North American studies. However, Brazilian epidemiological data demonstrate a higher prevalence, which may represent 27 to 80% of all canine HSAs and 13.9% of all skin neoplasms diagnosed in this species. Cutaneous HSA most commonly affects middle-aged to elderly dogs (between 8 and 15 years old), with no gender predisposition for either the actinic or non-actinic forms. The higher prevalence of cutaneous HSA in some canine breeds is related to lower protection from solar radiation, as low skin pigmentation and hair coverage lead to greater sun exposure. Actinic changes, such as solar dermatosis, are frequent in these patients, confirming the influence of solar radiation on the development of this neoplasm. There are multiple clinical manifestations of hemangiosarcoma in canines. The diagnostic approach and staging classification of cutaneous HSAs are similar between the different subtypes. The definitive diagnosis is obtained through histopathological analysis of incisional or excisional biopsies. Cytology can be used as a presurgical screening test; however, it has little diagnostic utility in cases of HSA because there is a high risk of blood contamination and sample hemodilution. Surgery is generally the treatment of choice for dogs with localized non-visceral HSA without evidence of metastatic disease. Recently, electrochemotherapy (ECT) has emerged as an alternative therapy for the local ablative treatment of different neoplastic types; the use of radiotherapy for the treatment of dogs with cutaneous HSA is uncommon. There is greater consensus in the literature regarding the indications for adjuvant chemotherapy in subcutaneous and muscular HSA; doxorubicin is the most frequently used antineoplastic agent for subcutaneous and muscular subtypes and can be administered alone or in combination with other drugs. Other therapies include antiangiogenic therapy, photodynamic therapy, the association of chemotherapy with the metronomic dose, targeted therapies, and natural products. The benefits of these therapies are presented and discussed. In general, the prognosis of splenic and cardiac HSA is unfavorable. As a challenging neoplasm, studies of new protocols and treatment modalities are necessary to control this aggressive disease.

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“…The relationship between increased ROS and iNOS underscores the critical importance of maintaining redox balance in cells to prevent excessive nitric oxide production and oxidative stress. Strategies aimed at reducing ROS levels or inhibiting iNOS activity hold potential for mitigating the detrimental effects of this interplay, offering promising therapeutic avenues for conditions characterized by oxidative stress and inflammation ( Nediani and Dinu, 2022 ). Our research findings have demonstrated that utilizing our innovative device significantly decreases the expression and activity of iNOS, a key contributor to inflammation and oxidative stress when overexpressed.…”

Section: Discussionmentioning

confidence: 99%

Biological effects of magnetic fields emitted by graphene devices, on induced oxidative stress in human cultured cells

Franceschelli,

D’Andrea,

Speranza

et al. 2024

Front. Bioeng. Biotechnol.

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Many recent studies have explored the healing properties of the extremely low-frequency electromagnetic field (ELF-EMF) to utilize electromagnetism for medical purposes. The non-invasiveness of electromagnetic induction makes it valuable for supportive therapy in various degenerative pathologies with increased oxidative stress. To date, no harmful effects have been reported or documented. We designed a small, wearable device which does not require a power source. The device consists of a substrate made of polyethylene terephthalate and an amalgam containing primarily graphene nanocrystals, also known as quantum dots. This device can transmit electromagnetic signals, which could induce biological effects. This study aims to verify the preliminary effects of the electromagnetic emission of the device on leukemic cells in culture. For this purpose, we studied the best-known effects of magnetic fields on biological models, such as cell viability, and the modulations on the main protagonists of cellular oxidative stress.

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Oxidative Stress and Inflammation as Targets for Novel Preventive and Therapeutic Approaches in Non-Communicable Diseases II

Cited by 10 publications

References 23 publications

In Patients with Chronic Kidney Disease Advanced Glycation End-Products Receptors Isoforms (sRAGE and esRAGE) Are Associated with Malnutrition

In Patients with Chronic Kidney Disease Advanced Glycation End-Products Receptors Isoforms (sRAGE and esRAGE) Are Associated with Malnutrition

Diagnosis, Prognosis, and Treatment of Canine Hemangiosarcoma: A Review Based on a Consensus Organized by the Brazilian Association of Veterinary Oncology, ABROVET

Biological effects of magnetic fields emitted by graphene devices, on induced oxidative stress in human cultured cells

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