Oxidative stress and inflammation associated with decreased fibrinolysis as an early marker for peripheral vascular disease stratification: A clinical study

Jelinek, Herbert F.; Khalaf, Kinda; Robinson, Caroline; McDonald, Simon; Butkowski, Eugene; Al-Aubaidy, Hayder A.; Wild, T. Cameron

doi:10.1016/j.wndm.2015.03.003

Cited by 1 publication

(6 citation statements)

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“…Biomarkers are the products of oxidative damage in the body. Identifying and investigating these biomarkers might be useful in the process of avoiding prediabetes situations (26,35). The following are some of the oxidative stress biomarkers related to prediabetes: 8-hydroxy-2'-deoxyguanosine (8-OHdG), malondialdehyde (MDA), and glutathione (GSH).…”

Section: Biomarkers Of Oxidative Stress In Prediabetesmentioning

confidence: 99%

“…Hyperglycaemia leads to the generation of excess free 8-hydroxy-2'-deoxyguanosine (8-OHdG) 8-OHdG is a biomarker of oxidative stress in prediabetes and diabetes mellitus, which results mainly from cellular DNA damage; it is the most frequently detected in prediabetes and diabetes mellitus (9,13,26,33). A recent study showed a significant increase of this marker in blood samples of 200 prediabetes compared to 200 control subjects (13).…”

Section: Oxidative Stress In Prediabetes the Relation Between Oxidati...mentioning

confidence: 99%

“…Thus, increased levels of 8-OHdG reflect an increase in the degree of oxidative stress and progressing of prediabetes condition toward diabetes (13,33). Therefore, early detection of oxidative stress biomarkers related to prediabetes such as 8-OHdG might be the key to treating prediabetes people and stopping the mechanism of converting to T2DM and its complications (9,26).…”

Section: Oxidative Stress In Prediabetes the Relation Between Oxidati...mentioning

confidence: 99%

“…Inflammation is part of the immune system to defeat against foreign materials and microorganisms. Inflammation is involved in the pathophysiology of many diseases and conditions such as prediabetes and diabetes mellitus; the cytokines might help identify prediabetes cases at risk of developing T2DM and complications (3,26,37). The following are some inflammatory markers related to prediabetes: interleukin-6 (IL-6), C-reactive protein (CRP), and fibrinogen (38,39).…”

Section: Inflammatory Markersmentioning

confidence: 99%

“…Inflammation and oxidative stress are known to be present in prediabetes patients and predispose them to dyslipidaemia and cardiovascular diseases (4,5,25). Oxidative stress and inflammatory components are also considered risk factors for peripheral vascular diseases (26).…”

Section: Introductionmentioning

confidence: 99%

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The Role of Oxidative Stress and Inflammation in Prediabetes: A Review

Saghir,

Ibrahim,

Amom

et al. 2023

MJMHS

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Prediabetes is a condition in which blood glucose level is above the normal but below the diagnostic value of diabetes mellitus. Hyperglycaemia can upregulate markers of chronic inflammation and contribute to the overproduction of reactive oxygen species (ROS), which ultimately causes increased oxidative stress. This leads to beta-cell dysfunction and insulin resistance, which are involved in the pathogenesis of prediabetes status. Proper treatment of hyperglycaemia, inhibition of ROS overproduction, and suppression of inflammation are crucial for delaying the onset of diabetes. Therefore, it is essential to determine and understand the mechanisms involved in prediabetes. This review discusses the relationship between oxidative stress and prediabetes, along with the inflammation’s role in prediabetes. Additionally, the effects of some biomarkers of oxidative stress in prediabetes, inflammatory markers, and their influence on chronic inflammation are also briefly reviewed. Finally, the role of antioxidant and anti-inflammatory markers are discussed.

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Section: Biomarkers Of Oxidative Stress In Prediabetesmentioning

confidence: 99%