Oxidative Stress and Inflammatory Biomarkers in People with Methamphetamine Use Disorder

Abstract

Objective This study aimed to investigate the blood serum levels of biomarkers specifying oxidative stress status and systemic inflammation between people using methamphetamine (METH) and the control group (CG). Serum thiol/disulfide balance and ischemia-modified albumin levels were studied to determine oxidative stress, and serum interleukin-6 (IL-6) levels and complete blood count (CBC) were to assess inflammation. Methods Fifty patients with METH use disorder (MUD) and 36 CG participants were included in the study. Two tubes of venous blood samples were taken to measure oxidative stress, serum thiol/disulfide balance, ischemia-modified albumin, and IL-6 levels between groups. The correlation of parameters measuring oxidative stress and inflammation between groups with sociodemographic data was investigated. Results In this study, serum total thiol, free thiol levels, disulfide/native thiol percentage ratios, and serum ischemia-modified albumin levels of the patients were statistically significantly higher than the healthy controls. No difference was observed between the groups in serum disulfide levels and serum IL-6 levels. Considering the regression analysis, only the duration of substance use was a statistically significant factor in explaining serum IL-6 levels. The parameters showing inflammation in the CBC were significantly higher in the patients than in the CG. Conclusion CBC can be used to evaluate systemic inflammation in patients with MUD. Parameters measuring thiol/disulfide homeostasis and ischemia-modified albumin can be, also, used to assess oxidative stress.

Ischemia-Modified Albumin (IMA) Is Associated with Poor Survival in Patients with Newly Diagnosed Idiopathic Pulmonary Fibrosis (IPF): A Pilot Study

“…However, while lower levels of ROS have several important physiological roles as signaling molecules, excessive ROS levels can be toxic and may trigger pathological conditions, including fibrosis [ 7 , 8 ]. Within the spectrum of oxidative stress biomarkers, ischemia-modified albumin (IMA) has emerged as a promising biomarker of oxidative stress [ 9 , 10 ]. IMA reflects the alteration of serum albumin due to the influence of reactive oxygen species that induces structural changes in the N-terminal region of proteins, which may be measured by spectrophotometry using the albumin cobalt binding (ACB) test [ 11 ].…”