Oxidative stress and innate immunity status in chickens exposed to high dose of ascorbic acid

Berzina, Nadezhda; Markovs, Jurijs; Dizhbite, Tatiana; Apsite, M. R.; Vasilyeva, Svetlana V.; N., Basova,; Смирнова, Г. В.; Isajevs, Sergejs

doi:10.1002/cbf.2934

Cited by 8 publications

(5 citation statements)

References 43 publications

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“…[17,[56][57][58][59] Imbalance of minerals (Se, Zn, Mn, Cu, etc.) and other nutrients [2,15,18,19,[60][61][62][63] Low water quality [2,18,19,[64][65][66][67] Usage of coccidiostats and other drugs via feed or water [2,18,19,68,69]…”

Section: Nutritional Stressorsmentioning

confidence: 99%

Antioxidant Defence Systems and Oxidative Stress in Poultry Biology: An Update

et al. 2019

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Poultry in commercial settings are exposed to a range of stressors. A growing body of information clearly indicates that excess ROS/RNS production and oxidative stress are major detrimental consequences of the most common commercial stressors in poultry production. During evolution, antioxidant defence systems were developed in poultry to survive in an oxygenated atmosphere. They include a complex network of internally synthesised (e.g., antioxidant enzymes, (glutathione) GSH, (coenzyme Q) CoQ) and externally supplied (vitamin E, carotenoids, etc.) antioxidants. In fact, all antioxidants in the body work cooperatively as a team to maintain optimal redox balance in the cell/body. This balance is a key element in providing the necessary conditions for cell signalling, a vital process for regulation of the expression of various genes, stress adaptation and homeostasis maintenance in the body. Since ROS/RNS are considered to be important signalling molecules, their concentration is strictly regulated by the antioxidant defence network in conjunction with various transcription factors and vitagenes. In fact, activation of vitagenes via such transcription factors as Nrf2 leads to an additional synthesis of an array of protective molecules which can deal with increased ROS/RNS production. Therefore, it is a challenging task to develop a system of optimal antioxidant supplementation to help growing/productive birds maintain effective antioxidant defences and redox balance in the body. On the one hand, antioxidants, such as vitamin E, or minerals (e.g., Se, Mn, Cu and Zn) are a compulsory part of the commercial pre-mixes for poultry, and, in most cases, are adequate to meet the physiological requirements in these elements. On the other hand, due to the aforementioned commercially relevant stressors, there is a need for additional support for the antioxidant system in poultry. This new direction in improving antioxidant defences for poultry in stress conditions is related to an opportunity to activate a range of vitagenes (via Nrf2-related mechanisms: superoxide dismutase, SOD; heme oxygenase-1, HO-1; GSH and thioredoxin, or other mechanisms: Heat shock protein (HSP)/heat shock factor (HSP), sirtuins, etc.) to maximise internal AO protection and redox balance maintenance. Therefore, the development of vitagene-regulating nutritional supplements is on the agenda of many commercial companies worldwide.

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Section: Nutritional Stressorsmentioning

confidence: 99%

Antioxidant Defence Systems and Oxidative Stress in Poultry Biology: An Update

et al. 2019

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“…This suggests that domestic fowl under heat stress should receive vitamin C supplementation. Ascorbic acid participates in several biological processes; it assists collagen synthesis and maintenance; it is essential for formation and maintenance of connective tissue, bone and cartilage; it, stimulates the immune system and enhances disease resistance (Farquharson et al, 1998;Berzina et al, 2013;Sgavioli et al, 2013;Chand et al, 2014). Finally, ascorbic acid influences the development of the leg bones in stressed birds (Lesson & Summers, 2001).…”

Section: Introductionmentioning

confidence: 99%

Effect of In-Ovo Ascorbic Acid Injection on the Bone Development of Broiler Chickens Submitted to Heat Stress During Incubation and Rearing

Sgavioli

Domingues

Santos

et al. 2016

Rev. Bras. Cienc. Avic.

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Ash, mineral density, femoral bone strength, tibia, vitamin C. ABSTRACTThis experiment was conducted to evaluate the effect of in-ovo ascorbic acid (AA) injection on the bone development of broilers submitted to heat stress during incubation and rearing. One thousand (1,000) Cobb ® fertile broiler eggs were randomly distributed according to the weight into five incubators, with 200 eggs per incubator. The incubation treatments were: eggs not injected with AA and incubated at 37.5°C; eggs not injected with AA and incubated at 39°C; and eggs injected with 6 µg AA/100 µL water prior to incubation and incubated at 39ºC. The hatched birds were reared at three different house temperatures: cold, thermoneutral, or and hot. The high incubation temperature negatively influenced broilers' bone characteristics. The femur of the birds hatched from eggs incubated at 39°C and injected with AA presented lower shaft mineral density, lower maximum force and lower elongation at maximum force. Their tibia presented reduced mineral density at the proximal and distal epiphysis. In-ovo AA injection of eggs incubated at high temperature did not minimize the negative effects of high rearing temperature on the performance andbone development of broiler chickens reared until 42 days of age.

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“…Collagen is a crucial component of human tissues, including the periodontal membrane, and is necessary for wound healing, periodontal regeneration, and the integrity of the gingival vasculature. Some evidence suggesting that vitamin C affects host immunoreaction by exerting an influence on phagocytosis in a chemotactic row of polymorphonuclear leukocytes has also been presented 22 23 …”

Section: Discussionmentioning

confidence: 99%

“…Some evidence suggesting that vitamin C affects host immunoreaction by exerting an influence on phagocytosis in a chemotactic row of polymorphonuclear leukocytes has also been presented. 22 Therefore, vitamin C is considered a main component of the human body's antioxidant defense mechanism. 23 A number of biological mechanisms have been suggested to explain how vitamin C can influence the periodontal condition.…”

Section: Discussionmentioning

confidence: 99%

Interaction between serum vitamin C levels and smoking on the periodontal condition in older adults

Yoshihara

Nakashima

Suwama

et al. 2022

J of Periodontal Research

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Background and Objectives: Several epidemiological studies have reported that smokers have a higher prevalence and severity of periodontal disease than do nonsmokers, and that smoking negatively affects nutritional status and is associated with a reduced intake of antioxidants, particularly vitamin C. The present investigation aimed to examine the relationship between serum vitamin C levels and smoking and its influence on the periodontal condition in older adults. Materials and Methods: A total of 353 respondents met the inclusion criteria andwere enrolled in the present study. The periodontal status of the study participants was determined through examinations of one or more residual teeth, which included a measurement of the probing pocket depth (PPD) and clinical attachment level (CAL) at six regions of each tooth. Blood samples were collected during the dental examinations and then sent to a laboratory to evaluate serum vitamin C and cotinine levels. A serum cotinine concentration of 100 ng/ml was considered a relevant threshold for active smoking. After dividing the participants into two groups according to serum cotinine levels, Poisson regression analysis was carried out to compare vitamin C levels with the prevalence rate ratio (PRR) for periodontal condition markers for each group based on serum cotinine levels.Results: We evaluated differences in the PRR of serum vitamin C tertiles between participants with high (≥100 ng/ml) or low (<100 ng/ml) serum cotinine levels after adjusting for sex, the use of interdental brushes or dental floss, and the number of teeth. A negative tendency between the PRR of vitamin C tertiles for the PPD or CAL was seen for both groups. Especially, a bigger difference was observed in the group with high serum cotinine levels. The PRR of the first tertiles in the high serum cotinine group was 5.03, compared with 2.69 in the low serum cotinine group (relative risk:1.9). Conclusion:The results of this study suggest a potential association between vitamin C levels and the periodontal condition, which may be influenced by smoking status.

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Oxidative stress and innate immunity status in chickens exposed to high dose of ascorbic acid

Cited by 8 publications

References 43 publications

Antioxidant Defence Systems and Oxidative Stress in Poultry Biology: An Update

Antioxidant Defence Systems and Oxidative Stress in Poultry Biology: An Update

Effect of In-Ovo Ascorbic Acid Injection on the Bone Development of Broiler Chickens Submitted to Heat Stress During Incubation and Rearing

Interaction between serum vitamin C levels and smoking on the periodontal condition in older adults

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