Oxidative stress and insulin resistance in policemen working shifts

Demir, Irfan; Toker, Aysun; Zengin, Suat; Laloğlu, Esra; Aksoy, Hülya

doi:10.1007/s00420-015-1079-1

Cited by 22 publications

(14 citation statements)

References 39 publications

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“…It has been reported that a number of key metabolic functions follow the circadian rhythms, 13 and epidemiological studies confirm that long‐term circadian misalignment associates with the development of insulin resistance, metabolic syndrome, and T2DM 14 . Animal experiments have confirmed that circadian rhythms of the T2DM classical model in db/db mice are disrupted completely 15 .…”

Section: Introductionmentioning

confidence: 93%

The association of energy and macronutrient intake at dinner vs breakfast with the incidence of type 2 diabetes mellitus in a cohort study: The China Health and Nutrition Survey, 1997‐2011

Ren

Yang

Jiang

et al. 2021

Journal of Diabetes

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Background This study aims to investigate the association of energy and macronutrient intake at dinner vs breakfast with the incidence of type 2 diabetes mellitus (T2DM). Methods A total of 11 153 adults, including 811 with T2DM, completed a questionnaire about energy and macronutrient intake in the China Health and Nutrition Survey (1997‐2011). The differences (Δ) in energy and macronutrient intake between dinner and breakfast (Δ = dinner − breakfast) were categorized into quintiles. Cox proportional hazards regression models were performed to explore the association between Δ and the risk of T2DM and to investigate the change of the risk when 5% total energy or energy provided by macronutrients at dinner was substituted with total energy or energy provided by macronutrients at breakfast by isocaloric substitution models. Results After adjustment for potential confounders, compared with participants in the lowest quintile, participants in the highest quintile were more likely to develop T2DM (hazard ratio [HR]Δenergy 1.46, 95% CI 1.13‐1.87; HRΔfat 1.85, 95% CI 1.43‐2.41; HRΔprotein 1.37, 95% CI 1.06‐1.78). Isocalorically replacing 5% energy at dinner with energy at breakfast was associated with a 7% lower T2DM risk. Replacing 5% energy provided by fat at dinner with energy provided by carbohydrate, protein, and fat at breakfast was associated with a 9%, 5%, and 7% lower T2DM risk, respectively. Replacing 5% energy provided by protein at dinner with energy provided by carbohydrate or protein at breakfast was associated with a 5% lower T2DM risk. Conclusions Higher intake of energy, protein, and fat at dinner than at breakfast increased the risk of T2DM.

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Section: Introductionmentioning

confidence: 93%

The association of energy and macronutrient intake at dinner vs breakfast with the incidence of type 2 diabetes mellitus in a cohort study: The China Health and Nutrition Survey, 1997‐2011

Ren

Yang

Jiang

et al. 2021

Journal of Diabetes

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“…Epidemiological studies suggest that long-term circadian misalignment, such as occurs with shift work, is a risk factor for insulin resistance (13), type 2 diabetes (9), metabolic syndrome (27), obesity (10,16,52,55), hyperlipidemia (7), and nonalcoholic fatty liver disease (NAFLD) (34,35). There are various animal models to mimic human shift work, including altering the timing of food intake, activity, sleep, or light exposure (40).…”

Section: Introductionmentioning

confidence: 99%

A rotating light cycle promotes weight gain and hepatic lipid storage in mice

Christie

Vincent

et al. 2018

American Journal of Physiology-Gastrointestinal and Liver Physi

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Processes involved in regulation of energy balance and intermediary metabolism are aligned to the light-dark cycle. Shift-work and high fat diet (HFD)-induced obesity disrupt circadian rhythmicity and are associated with increased risk of non-alcoholic fatty liver disease (NAFLD). This study aimed to determine the effect of simulating shift work on hepatic lipid accumulation in lean and HFD-mice. C57BL/6 mice fed a standard laboratory diet (SLD) or HFD for 4wks were further allocated to a normal light (NL)-cycle (lights on:0600-1800hr) or rotating light (RL)-cycle (3-days NL and 4-days reversed (lights on:1800-0600hr) repeated) for 8wks. Tissue was collected every 3hrs beginning at 0600hr. HFD-mice gained more weight than SLD-mice, and RL-mice gained more weight than NL-mice. SLD-NL and HFD-NL mice, but not RL-mice, were more active, had higher respiratory quotients and consumed/expended more energy during the dark phase compared to the light phase. Blood glucose and plasma cholesterol and triglyceride concentrations were elevated in HFD and SLD-RL compared to SLD-NL mice. Hepatic glycogen was elevated in HFD compared to SLD-mice. Hepatic triglycerides were elevated in SLD-RL and HFD-mice compared to SLD-NL. Circadian rhythmicity of hepatic acetyl-CoA carboxylase (ACACA) mRNA was phase shifted in SLD-RL and HFD-NL and lost in HFD-RL mice. Hepatic ACACA protein was reduced in SLD-RL and HFD-mice compared to SLD-NL mice. Hepatic adipose triglyceride lipase was elevated in HFD-NL compared to SLD-NL but lower in RL-mice compared to NL-mice irrespective of diet. -Conclusion: A RL-cycle model of shift-work promotes weight gain and hepatic lipid storage even in lean conditions.

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“…So increased CRP due to reduced sleep could lead to systemic inflammation, but CRP is a nonspecific inflammatory marker and there are factors that might have role in association between night work and low grade inflammation including circadian disruption, poor sleep quality and reduce sleep duration. Nevertheless CRP can be a useful biomarker to assess the risk of future diabetes and metabolic syndrome, 39 it could be used to monitor metabolic risk in night shift workers. Metabolic risk and oxidative stress are grouped into high and low risk.…”

Section: Inflammatory Marker and Night Shiftmentioning

confidence: 99%

Association between metabolic risk, oxidative stress and rotating shift work in a tertiary health care facility

Gowda

Sukumar

Gowda

2019

Clinical Epidemiology and Global Health

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Healthcare industry employees, work in rotating shift duties to provide 24/7 services. Shift work is known to disrupt circadian rhythm and predispose the employees to metabolic risk and oxidative stress, subsequently increasing the risk for Non-Communicable Diseases. Present study attempts to evaluate this association. Aims: To evaluate the association between metabolic risk and oxidative stress among health care personnel working in rotating night-shift as compared to dayshift. Settings and design: Cross sectional study. Methods and materials: Eligible 124 employees [(night shift (61), Day shift (63)] working in a tertiary care hospital in Bengaluru were randomly selected and tested for anthropometric and laboratory parameters pertaining to metabolic risk and oxidative stress and categorized accordingly using standard criteria. Statistical tests (student t-test) were applied to test for association between shift work, metabolic risk and oxidative stress. Results: Metabolic risk and Oxidative stress were significantly higher in rotating night shift workers as compared to day shift (p < 0.001) and (p < 0.017) respectively. Conclusion: Rotating night shift work is associated with increase in metabolic risk and oxidative stress and there is a need to consider this enhanced risk during periodical medical examination and employee health interventions. There is a need for further research to quantify risk for metabolic risk and understand this association in other occupations as well.

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Oxidative stress and insulin resistance in policemen working shifts

Abstract: It may be concluded that 12/24 shift system might give rise to insulin resistance and oxidative stress. Additionally, workers in this system may under risk of systemic inflammatory response. Working hours must be arranged in accordance with the physiological rhythm.

Cited by 22 publications

References 39 publications

The association of energy and macronutrient intake at dinner vs breakfast with the incidence of type 2 diabetes mellitus in a cohort study: The China Health and Nutrition Survey, 1997‐2011

The association of energy and macronutrient intake at dinner vs breakfast with the incidence of type 2 diabetes mellitus in a cohort study: The China Health and Nutrition Survey, 1997‐2011

A rotating light cycle promotes weight gain and hepatic lipid storage in mice

Association between metabolic risk, oxidative stress and rotating shift work in a tertiary health care facility

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