Male Infertility 2020
DOI: 10.1007/978-3-030-32300-4_6
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Oxidative Stress and Its Association with Male Infertility

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Cited by 49 publications
(42 citation statements)
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“…1); this finding agrees with previously reported results [24,25]. The negative correlation between ROS and antioxidants has been confirmed; low seminal antioxidant potential allows ROS overproduction in infertile men [26]. The exposure to ROS is extremely destructive to sperm plasma membrane [12].…”
Section: Discussionsupporting
confidence: 90%
“…1); this finding agrees with previously reported results [24,25]. The negative correlation between ROS and antioxidants has been confirmed; low seminal antioxidant potential allows ROS overproduction in infertile men [26]. The exposure to ROS is extremely destructive to sperm plasma membrane [12].…”
Section: Discussionsupporting
confidence: 90%
“…ROS have a determinant role regarding the causes of abnormal sperm function. Excessive ROS production the seminal plasma seems to be associated with reduced sperm fertilising potential, impaired metabolism, motility and morphology (Agarwal & Sengupta, 2020). ROS‐induced cell damage occurs due to an unbalanced cell redox, especially when the antioxidant systems cannot compensate for the increased ROS.…”
Section: Discussionmentioning
confidence: 99%
“…Depending on the concentration, location and time of exposure, ROS can have a beneficial or harmful effect on spermatozoa. At normal physiological levels, ROS are essential for motility, capacitation, hyperactivation, acrosome reaction and, therefore, fertilisation (Agarwal & Sengupta, 2020; Di Meo et al., 2016). Overproduction of free radicals exceeding the antioxidant capacity of both the spermatozoa and the seminal plasma, known as oxidative stress (OS), can lead to apoptosis, lipid peroxidation, low sperm quality, and protein and DNA damage (Aitken, 2017; Subramanian et al., 2018).…”
Section: Introductionmentioning
confidence: 99%
“…ROS are major causes of sperm DNA damage (Agarwal & Sengupta, 2020). ROS affect spermatozoa mainly during the transit through the epididymis where they enhance endonuclease and caspases activities, resulting in an increasing rate of germ cell apoptosis (Sakkas & Alvarez, 2010).…”
Section: What Are the Current Guidelines For Testing Sperm Dna Intementioning
confidence: 99%