Oxidative stress and its biological significance

Uyeda, Mari

doi:10.1016/b978-0-323-90905-1.00003-1

Cited by 2 publications

(2 citation statements)

References 165 publications

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“…31 Additionally, the elevated IFN-gamma signaling in OA can be contrasted with an enrichment for IFN-beta signaling in non-OA conditions, suggesting the significantly different roles these two players can play in promoting the progression of the disease 24 and promoting joint health 42 , respectively. Furthermore, we observed upregulation of NFATC2 and ENTPD1-important for T-cell activation and inflammation modulation, respectively 43,44 . The upregulation of NFATC2 not only influences T-cell activation but also intersects with cartilage integrity and protection mechanisms 45 .…”

Section: Discussionmentioning

confidence: 76%

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Cellular and molecular changes in the human osteoarthritic and aging hip pulvinar

Tilouche,

Farhat,

Short

et al. 2024

Preprint

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Osteoarthritis (OA) represents a multifaceted pathology characterized by intricate signaling across various joint tissues, where the sub-synovial adipose tissue (ssAT) has been suggested to play diverse roles, from serving as a stem cell reservoir, mechanosensing, serving as a neuroendocrine organ, to modulating inflammation. In this study, we aimed to uncouple the cellular and molecular alterations within the human hip ssAT (the pulvinar) linked to OA and aging, elucidating the distinct contributions of disease onset and progression versus normal aging. Our findings show a pronounced increase in mesenchymal stem/progenitor cells (MSPCs) in the osteoarthritic pulvinar, associated with the upregulation of putative MSPC markers (DPP4, and THY1), indicating an adaptive repair response. Concurrently, in OA patients we observed an altered immune landscape featuring reduced innate immune cells and elevated exhausted CD8+ cells, along with upregulation of genes critical for inflammation and fibroblast activation. Our findings reveal a nuanced picture of OA, where increased stem cell numbers and vascularization, combined with specific gene expression patterns differentiate OA from normal aging. This study not only delineates the roles of inflammation, immune regulation, and stem cell activity in the OA pulvinar but also identifies potential therapeutic targets to modulate these pathways, offering novel insights into OA as a complex interplay of degenerative and intrinsic tissue repair.

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Section: Discussionmentioning

confidence: 76%

“…Furthermore, we observed upregulation of NFATC2 and ENTPD1—important for T-cell activation and inflammation modulation, respectively 43,44 . The upregulation of NFATC2 not only influences T-cell activation but also intersects with cartilage integrity and protection mechanisms 45 .…”

Section: Discussionmentioning

confidence: 77%

Cellular and molecular changes in the human osteoarthritic and aging hip pulvinar

Tilouche,

Farhat,

Short

et al. 2024

Preprint

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Anti-Aging Effect of Traditional Plant-Based Food: An Overview

Das,

Kameswaran,

Ramesh

et al. 2024

Foods

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Aging is a complex process that involves many physiological mechanisms that gradually impair normal cellular and tissue function and make us more susceptible to diseases and death. It is influenced by intrinsic factors like cellular function and extrinsic factors like pollution and UV radiation. Recent scientific studies show that traditional plant-based foods and supplements can help mitigate the effects of aging. Nutraceuticals, which are dietary supplements with medicinal properties, have gained attention for their ability to prevent chronic and age-related diseases. Antioxidants like flavonoids, carotenoids, ascorbic acid, terpenes, tannins, saponins, alkaloids, minerals, etc. found in plants are key to managing oxidative stress, which is a major cause of aging. Well-known plant-based supplements from Bacopa monnieri, Curcuma longa, Emblica officinalis, Ginkgo biloba, Glycyrrhiza glabra, and Panax ginseng have been found to possess medicinal properties. These supplements have been shown to improve cognitive function, reduce oxidative stress, improve overall health, and potentially extend life and enhance the excellence of life. The obtained benefits from these plant species are due to the presence of their bioactive secondary metabolites, such as bacosides in Bacopa monnieri, curcumin in Curcuma longa, ginsenosides in Panax ginseng, and many more. These compounds not only protect against free radical damage but also modulate key biological pathways of aging. Also, traditional fermented foods (tempeh and kimchi), which are rich in probiotics and bioactive compounds, support gut health, boost immune function, and have anti-aging properties. The molecular mechanisms behind these benefits are the activation of nutrient-sensing pathways like AMPK, SIRT/NAD+, and mTOR, which are important for cellular homeostasis and longevity. This review shows the potential of traditional plant-based foods and dietary supplements for healthy aging, and more studies are needed to prove their efficacy and safety in humans. Incorporating these natural products into our diet may be a practical and effective way to counteract the effects of aging and overall well-being. The foremost goal of this review is to emphasize the importance of supporting the body’s antioxidant system by consuming the right balance of natural ingredients in the diet.

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Oxidative stress and its biological significance

Cited by 2 publications

References 165 publications

Cellular and molecular changes in the human osteoarthritic and aging hip pulvinar

Cellular and molecular changes in the human osteoarthritic and aging hip pulvinar

Anti-Aging Effect of Traditional Plant-Based Food: An Overview

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