Oxidative stress and left ventricular dysfunction following acute coronary syndrome

Charfeddine, S.; Abid, Leïla; Ali, Z. Ben; Yousfi, C.; Gtif, Imen; Hammami, R.; Kammoun, S.

doi:10.1016/j.acvdsp.2019.09.038

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“…Cardiovascular risk factors result in endothelial injury and propagate atherosclerosis [ 2 ]. Accordingly, acute myocardial infarction (MI) is one of the most prevalent forms of ischemic heart diseases [ 3 ]. The most important decision for a patient with ST-segment elevation myocardial infarction (STEMI) is the early and successful myocardial reperfusion by the use of thrombolytic therapy or primary percutaneous coronary intervention (PPCI), which has been shown as effective method on balancing the blood supply as well as demanding and improving the clinical outcome [ 4 – 6 ].…”

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confidence: 99%

Oxidative stress and its association with ST resolution and clinical outcome measures in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention

et al. 2020

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Objective Reperfusion of ischemic myocardium generates oxidative stress, which itself can mediate myocardial injury. So, in this study, we investigated the level of oxidative stress markers and its association with clinical outcomes in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention. Results As indicated in the results, Post MI (Myocardial Infarction) heart failure was significantly higher in the group A (11% vs 4%, p = 0.047). Complete STR (ST-segment resolution) was observed to be significantly higher in the group B (36% vs 17%, p = 0.006). The SOD (Superoxide dismutase) and GPX (Glutathione peroxidase) levels were significantly higher in the group B compared to the other group (1547.51 ± 328.29 vs. 1449.97 ± 246.06, p = 0.019 and 60.62 ± 11.95 vs 57.41 ± 10.14, p = 0.042). The levels of GPX and SOD were shown to be directly related with complete STR and post PCI (Percutaneous coronary intervention)TIMI(Thrombolysis in Myocardial Infarction) flow 3 in the group A (p = 0.002 and p < 0.01, p = 0.005 and p < 0.02, respectively).

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