Oxidative stress and liver disease

Abstract

In humans, oxidative stress and antioxidant defenses are the sum of a complicated network of enzymatic and non-enzymatic processes. Depending on the stage and severity of diseases, a patient's antioxidant armamentarium may increase as an appropriate response to an oxidant challenge, whereas others may decrease as an indication of unbalanced consumption. In some cases, the formation of reactive oxygen species is a requisite and healthy event. In fact, free radicals can affect intracellular signal transduction and gene regulation, resulting in cytokine production essential to the inflammatory process. In many other cases, especially liver diseases, excessive oxidative stress undoubtedly contributes to the progression and pathological findings of disease and serves as a prognostic indicator. Reactive oxygen species are highly reactive molecules that are naturally generated in small amounts through metabolism and could damage cellular molecules such as lipids, proteins or DNA. Oxidative stress plays a major role in many liver diseases. In this review, we summarize the biological character of free radicals and some antioxidants, and the related methods of analysis. Then, we discusses the association of oxidative stress to many types of liver diseases.

Biological Studies on Some Nutritional Products Supplemented With Fish Oil for Hyperlepidmic Rats.

“…The obtained results were in parallel with Zhu et al(2012) found that Post-transplant parenteral nutritional support combined with omega-3 fatty acids can significantly improve the liver in jury, reduce the infectious morbidities, and shorten the post-transplant hospital stay.…”

Biochanin A Protects against Acute Carbon Tetrachloride-Induced Hepatotoxicity in Rats

“…30) As seen by our results, during hepatotoxicity, these enzymes are structurally and functionally impaired by an overload of free radicals, resulting in dysfunction. 31) BCA restored their levels and even boosted their activities at higher doses. A similar effect was seen in the level of GR, which was significantly decreased by CCl 4 and boosted by BCA administration.…”

Glutathione and glutathione S-transferase levels in patients with liver metastases of colorectal cancer and other hepatic disorders

“…However, the excessive formation of ROS and their reactive derivatives induces oxidative stress, which is associated with different chronic pathologic conditions, including cancer as well as liver diseases (1)(2)(3)(4)(5).…”