Oxidative Stress and Major Depression

Bajpai, A; Verma, Akhilesh K.; Srivastava, Mona; Srivastava, Ragini

doi:10.7860/jcdr/2014/10258.5292

Cited by 136 publications

(149 citation statements)

References 31 publications

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“…Thus, increased corticosterone level is often used as an important indicator of chronic stress response [de Kloet et al, ; Oken et al, ]. Excess cortisol produced during chronic stress response can damage vital organs of the body especially the brain via the induction of oxidative stress and neuroinflammation [Bajpai et al, ; Munhoz et al, ; Oken et al, ; Umukoro et al, ; Vaváková et al, ]. There is a growing body of literature that supports a role of oxidative stress and neuroinflammation in the pathophysiology of depression [Bajpai et al, ; Munhoz et al, ; Vaváková et al, ].…”

Section: Discussionmentioning

confidence: 99%

“…The extent of oxidative stress‐induced tissue damage is often quantify by the levels of MDA and GSH as well as the activity of antioxidant enzymes. High levels of MDA, a major marker of the extent of oxidative stress‐mediated tissue damage, occur in patients with depression [Bajpai et al, ; Munhoz et al, ; Vaváková et al, ]. Studies have also shown a close correlation between clinical outcomes of antidepressant treatment and level of oxidative stress in the brains of depressed patients [Munhoz et al, ; Vaváková et al, ].…”

Section: Discussionmentioning

confidence: 99%

“…Studies have also shown a close correlation between clinical outcomes of antidepressant treatment and level of oxidative stress in the brains of depressed patients [Munhoz et al, ; Vaváková et al, ]. Also, elevated levels of inflammatory cytokines in the brains of patients with depressive disorders have been reported [Bajpai et al, ; Munhoz et al, ; Vaváková et al, ]. Accordingly, oxidative and inflammatory pathways are viewed as potential targets for the development of novel antdepressants [Bajpai et al, ; Munhoz et al, ; Vaváková et al, ].…”

Section: Discussionmentioning

confidence: 99%

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Methyl Jasmonate Ameliorates Unpredictable Chronic Mild Stress‐Induced Behavioral and Biochemical Alterations in Mouse Brain

Adebesin

Ajayi

Olonode

et al. 2017

Drug Development Research

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Preclinical Research The effects of methyl jasmonate (MJ; 5, 10, 20 mg/kg, i.p), a natural product widely used for the relief of stress, depression, and exhaustion on unpredictable chronic mild stress (UCMS)-induced depression-like behaviors in mice was assessed and compared to those of imipramine (IMP; 10 mg/kg, i.p). MJ and IMP were given 30 min before exposure to UCMS with the procedure repeated daily for 2 weeks; 24 h after the stress session, the tail suspension test (TST) and sucrose preference test were assessed. MJ decreased immobility time in the TST and reversed impaired intake of sucrose relative to the stressed control suggesting antidepressant-like activity. MJ also reduced UCMS-induced increases in corticosterone and MDA (malondialdehyde) levels and attenuated UCMS-induced decreases in GSH and TNF-α levels and SOD activity. These findings suggest that MJ attenuated UCMS-induced depressive-like behaviors through decreased levels of corticosterone and decreasing oxidative stress and neuroinflammation in mouse brain.Drug Dev Res 78 : 381-389, 2017. © 2017 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Methyl Jasmonate Ameliorates Unpredictable Chronic Mild Stress‐Induced Behavioral and Biochemical Alterations in Mouse Brain

Adebesin

Ajayi

Olonode

et al. 2017

Drug Development Research

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“…Oxidative stress related disturbances in SZ, BD and MD are an integral part of these diseases, yet our understanding of the underlying pathophysiology is quite limited (Bajpai et al, 2014; Reyazuddin et al, 2014). As free radicals are found in very low concentrations in human biomaterials and have short half-life (Reyazuddin et al, 2014), the majority of past experiments relied on indirect measures of oxidative stress such as DNA damage, lipid peroxidation, levels of antioxidants and enzyme sets in the blood or the brain tissue (Reyazuddin et al, 2014).…”

Section: Understanding Pathophysiological Processes Using Hdfsmentioning

confidence: 99%

“…Postmortem and peripheral biomarker studies reveal a diminished ability to maintain redox homeostasis in psychiatric disorders (Bajpai et al, 2014; Reyazuddin et al, 2014). In addition, HDF cultures obtained from SZ and MD patients show impaired GSH regeneration (Gysin et al, 2007; 2009; Tosic et al, 2006; Cohen et al, 1986; Gibson et al, 2012; Ranjekar et al, 2003).…”

Section: Similarities Between Hdf and Cns Cellsmentioning

confidence: 99%

Human dermal fibroblasts in psychiatry research

et al. 2016

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Summary In order to decipher the disease etiology, progression and treatment of multifactorial human brain diseases we utilize a host of different experimental models. Recently, patient-derived human dermal fibroblast (HDF) cultures have re-emerged as promising in vitro functional system for examining various cellular, molecular, metabolic and (patho)physiological states and traits of psychiatric disorders. HDF studies serve as a powerful complement to postmortem and animal studies, and often appear to be informative about the altered homeostasis in neural tissue. Studies of HDFs from patients with schizophrenia, depression, bipolar disorder, autism, attention deficit and hyperactivity disorder and other psychiatric disorders have significantly advanced our understanding of these devastating diseases. These reports unequivocally prove that signal transduction, redox homeostasis, circadian rhythms and gene*environment interactions are all amenable for assessment by the HDF model. Furthermore, the reported findings suggest that this underutilized patient biomaterial, combined with modern molecular biology techniques, may have both diagnostic and prognostic value, including prediction of response to therapeutic agents.

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Associations of Depression, Anxiety, Worry, Perceived Stress, and Loneliness Prior to Infection With Risk of Post–COVID-19 Conditions

et al. 2022

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ImportanceFew risk factors for long-lasting (≥4 weeks) COVID-19 symptoms have been identified.ObjectiveTo determine whether high levels of psychological distress before SARS-CoV-2 infection, characterized by depression, anxiety, worry, perceived stress, and loneliness, are prospectively associated with increased risk of developing post–COVID-19 conditions (sometimes called long COVID).Design, Setting, and ParticipantsThis prospective cohort study used data from 3 large ongoing, predominantly female cohorts: Nurses’ Health Study II, Nurses’ Health Study 3, and the Growing Up Today Study. Between April 2020 and November 2021, participants were followed up with periodic surveys. Participants were included if they reported no current or prior SARS-CoV-2 infection at the April 2020 baseline survey when distress was assessed and returned 1 or more follow-up questionnaires.ExposuresDepression, anxiety, worry about COVID-19, perceived stress, and loneliness were measured at study baseline early in the pandemic, before SARS-CoV-2 infection, using validated questionnaires.Main Outcomes and MeasuresSARS-CoV-2 infection was self-reported during each of 6 monthly and then quarterly follow-up questionnaires. COVID-19–related symptoms lasting 4 weeks or longer and daily life impairment due to these symptoms were self-reported on the final questionnaire, 1 year after baseline.ResultsOf 54 960 participants, 38.0% (n = 20 902) were active health care workers, and 96.6% (n = 53 107) were female; the mean (SD) age was 57.5 (13.8) years. Six percent (3193 participants) reported a positive SARS-CoV-2 test result during follow-up (1-47 weeks after baseline). Among these, probable depression (risk ratio [RR], 1.32; 95% CI = 1.12-1.55), probable anxiety (RR = 1.42; 95% CI, 1.23-1.65), worry about COVID-19 (RR, 1.37; 95% CI, 1.17-1.61), perceived stress (highest vs lowest quartile: RR, 1.46; 95% CI, 1.18-1.81), and loneliness (RR, 1.32; 95% CI, 1.08-1.61) were each associated with post–COVID-19 conditions (1403 cases) in generalized estimating equation models adjusted for sociodemographic factors, health behaviors, and comorbidities. Participants with 2 or more types of distress prior to infection were at nearly 50% increased risk for post–COVID-19 conditions (RR, 1.49; 95% CI, 1.23-1.80). All types of distress were associated with increased risk of daily life impairment (783 cases) among individuals with post–COVID-19 conditions (RR range, 1.15-1.51).Conclusions and RelevanceThe findings of this study suggest that preinfection psychological distress may be a risk factor for post–COVID-19 conditions in individuals with SARS-CoV-2 infection. Future work should examine the biobehavioral mechanism linking psychological distress with persistent postinfection symptoms.

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Oxidative Stress and Major Depression

Cited by 136 publications

References 31 publications

Methyl Jasmonate Ameliorates Unpredictable Chronic Mild Stress‐Induced Behavioral and Biochemical Alterations in Mouse Brain

Methyl Jasmonate Ameliorates Unpredictable Chronic Mild Stress‐Induced Behavioral and Biochemical Alterations in Mouse Brain

Human dermal fibroblasts in psychiatry research

Associations of Depression, Anxiety, Worry, Perceived Stress, and Loneliness Prior to Infection With Risk of Post–COVID-19 Conditions

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