Oxidative Stress and Male Infertility: The Protective Role of Antioxidants

Abstract

Oxidative stress is a significant factor in male infertility, compromising sperm function and overall reproductive health. As male infertility garners increasing attention, effective therapeutic interventions become paramount. This review investigates the therapeutic role of antioxidants in addressing male infertility. A detailed examination was conducted on antioxidants such as vitamin C, E, B12, D, coenzyme Q10, zinc, folic acid, selenium, l-carnitine, l-arginine, inositols, and alpha-lipoic acid. This analysis examines the methodologies, outcomes, and constraints of current clinical studies. Antioxidants show notable potential in counteracting the negative effects of oxidative stress on sperm. Based on the evidence, these antioxidants, individually or synergistically, can enhance sperm health and reproductive outcomes. However, certain limitations in the studies call for careful interpretation. Antioxidants are integral in tackling male infertility attributed to oxidative stress. The current findings underscore their therapeutic value, yet there’s a pressing need for deeper, comprehensive research. Future studies should focus on refining dosage guidelines, identifying potential side effects, and discerning the most efficacious antioxidant combinations for male infertility solutions.

Spermotrend Improves Semen Quality and Infertility in Men with Varicocele <br/>—Spermotrend and Male Infertility

“…Regarding the varicocele condition, the percentage of patients with varicocele grade Therefore, this study demonstrates that daily supplementation of Spermotrend for a continuous period of 6 months has a beneficial effect on sperm quality and the control of venous flow and dilation associated with varicocele, despite the heterogeneity of altered parameters associated with male infertility. The antioxidants and micronutrients of Spermotrend ® help restore proper REDOX balance and sperm metabolism, thus promoting the correct sperm morphology, motility, mobility, and maturation [44].…”

Ameliorative role of β-Caryophyllene on antioxidant biomarkers in Paroxetine induced erectile dysfunctional rats

“…Empirical evidence has demonstrated that an imbalance between free radical generation and antioxidant defense capacity in the testes and epididymis of rats may signify sexual dysfunction (Aitken & Roman, 2008;Finelli et al, 2022;Kaltsas, 2023). Reactive oxygen species, particularly superoxides, play a central role in the impairment of erectile function within cavernosal tissues (Agarwal et al, 2006).…”

Effects of Chicory (Cichorium intybus L.) Extract on Male Rat Reproductive System, Pregnancy and Offspring Development

“…Excessive oxidative stress is one of the mechanisms responsible for male infertility [ 29 , 30 , 31 ]. It damages spermatozoan activities and male fertility.…”