Oxidative stress and male infertility

Bisht, Shilpa; Faiq, Muneeb A.; Tolahunase, Madhuri; Dada, Rima

doi:10.1038/nrurol.2017.69

Cited by 655 publications

(437 citation statements)

References 183 publications

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“…Tobacco smoking has adverse effects on human fertility, reproduction, and early development 34 , 35 . The most consistent association with offspring’s asthma has been found for maternal smoking during pregnancy, 1–4 which may permanently affect the lungs 5 .…”

Section: Discussionmentioning

confidence: 99%

A three-generation study on the association of tobacco smoking with asthma

Accordini

Calciano

Johannessen

et al. 2018

International Journal of Epidemiology

102

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BackgroundMothers’ smoking during pregnancy increases asthma risk in their offspring. There is some evidence that grandmothers’ smoking may have a similar effect, and biological plausibility that fathers’ smoking during adolescence may influence offspring’s health through transmittable epigenetic changes in sperm precursor cells. We evaluated the three-generation associations of tobacco smoking with asthma.MethodsBetween 2010 and 2013, at the European Community Respiratory Health Survey III clinical interview, 2233 mothers and 1964 fathers from 26 centres reported whether their offspring (aged ≤51 years) had ever had asthma and whether it had coexisted with nasal allergies or not. Mothers and fathers also provided information on their parents’ (grandparents) and their own asthma, education and smoking history. Multilevel mediation models within a multicentre three-generation framework were fitted separately within the maternal (4666 offspring) and paternal (4192 offspring) lines.ResultsFathers’ smoking before they were 15 [relative risk ratio (RRR) = 1.43, 95% confidence interval (CI): 1.01–2.01] and mothers’ smoking during pregnancy (RRR = 1.27, 95% CI: 1.01–1.59) were associated with asthma without nasal allergies in their offspring. Grandmothers’ smoking during pregnancy was associated with asthma in their daughters [odds ratio (OR) = 1.55, 95% CI: 1.17–2.06] and with asthma with nasal allergies in their grandchildren within the maternal line (RRR = 1.25, 95% CI: 1.02–1.55).ConclusionsFathers’ smoking during early adolescence and grandmothers’ and mothers’ smoking during pregnancy may independently increase asthma risk in offspring. Thus, risk factors for asthma should be sought in both parents and before conception.FundingEuropean Union (Horizon 2020, GA-633212).

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Section: Discussionmentioning

confidence: 99%

A three-generation study on the association of tobacco smoking with asthma

Accordini

Calciano

Johannessen

et al. 2018

International Journal of Epidemiology

102

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“…Sperm cells are susceptible to oxidative stress due to high content of unsaturated fatty acids, limited antioxidant defence and DNA repair mechanisms which may lead to membrane and DNA damage. [41] Free radicals are capable of reducing sperm motility and viability via peroxidation of lipid membranes, impaired mitochondrial function, reduction of ATP and energy levels. [42] This present study demonstrates that scopolamine triggered an increase in the production of ROS in rats testicular and epididymal tissues.…”

Section: Discussionmentioning

confidence: 99%

Caffeine improves sperm quality, modulates steroidogenic enzyme activities, restore testosterone levels and prevent oxidative damage in testicular and epididymal tissues of scopolamine-induced rat model of amnesia

Akomolafe

Olasehinde

Ogunsuyi

et al. 2019

Journal of Pharmacy and Pharmacology

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Objectives This study was designed to assess the role of caffeine on fertility parameters in testicular and epididymal tissues of scopolamine‐induced model of amnesia in rats. Methods Adult male rats were treated with scopolamine with or without caffeine. The modulatory effects of caffeine or scopolamine on fertility parameters were assessed in rats' testicular and epididymal homogenates. Key findings Scopolamine‐induced sperm abnormalities, reduced steroidogenic enzyme 3β‐Hydroxysteroid dehydrogenase (3β‐HSD) and 17β‐Hydroxysteroid dehydrogenase (17β‐HSD) activities and serum testosterone levels in rats' testicular tissues. Treatment with caffeine increased 3β‐HSD and 17β‐HSD as well as testosterone levels. Caffeine also reversed sperm viability, sperm motility and sperm count in testicular tissues of scopolamine‐treated rats. Furthermore, scopolamine‐induced oxidative damage in rats' epididymal and testicular tissues via reduction of thiol and non‐protein thiol content as well as increase in reactive oxygen species (ROS) and malondialdehyde (MDA) levels. Caffeine attenuated oxidative stress in testicular and epididymal tissues of rats treated with scopolamine via increase in non‐protein and protein thiol levels with concomitant reduction in ROS and MDA levels. Conclusion This study revealed that caffeine (5 and 25 mg/kg) improved sperm quality, increased steroidogenic enzyme activities and attenuated oxidative damage in testis and epididymis of rats treated with scopolamine.

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“…These characteristics make spermatozoa vulnerable to oxidative attack (Aitken, 2013;Bisht, Faiq, Tolahunase, & Dada, 2017). As evident from our previous studies, the spermatozoa of RPL patients exhibit a greater degree of damage by oxidative stress and it is plausible that such damage may be incorporated in embryos with a normal chromosome complement (Mohanty, Swain, Goswami, Kar, & Samanta, 2016).…”

mentioning

confidence: 88%

Quantitative proteomics decodes clusterin as a critical regulator of paternal factors responsible for impaired compensatory metabolic reprogramming in recurrent pregnancy loss

et al. 2019

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Recurrent pregnancy loss (RPL) is a perplexing problem experienced with two or more consecutive miscarriages wherein the cause remains unexplained in >50% of cases. However, despite several evidences of involvement of paternal factors on early embryogenesis and placental development, its contribution towards RPL has been largely unexplored. There is augmented lipid peroxidation, protein carbonylation, thionylation and enhanced histone retention in spermatozoa of RPL patients. Differentially expressed proteins in the spermatozoa of RPL patients may contribute towards aberrant embryo development and pregnancy loss. The present study comprised of male partners of RPL patients (n = 16) with the absence of any female factor abnormality and age‐matched fertile healthy donors (n = 20). Pooled sperm samples from each group were subjected to high‐throughput liquid chromatography–tandem mass spectrophotometry (LC‐MS/MS) and subsequent bioinformatic analysis that identifies key proteins to be differentially expressed (DEPs). A total of 23 DEPs were identified with ≥2.0 fold change were considered to be significant. A key finding of the study was clusterin (CLUS), a predominant oxidative stress protein that takes part in an array of pre‐ and post‐fertilisation molecular processes, found to be underexpressed as it was confirmed by Western blot analysis. This pilot study supports contributions of paternal oxidative predominance in RPL and encourages further investigation.

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Oxidative stress and male infertility

Cited by 655 publications

References 183 publications

A three-generation study on the association of tobacco smoking with asthma

A three-generation study on the association of tobacco smoking with asthma

Caffeine improves sperm quality, modulates steroidogenic enzyme activities, restore testosterone levels and prevent oxidative damage in testicular and epididymal tissues of scopolamine-induced rat model of amnesia

Quantitative proteomics decodes clusterin as a critical regulator of paternal factors responsible for impaired compensatory metabolic reprogramming in recurrent pregnancy loss

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