Oxidative stress and metabolic parameters in hypertensive patients with/without diabetes mellitus in cardiovascular risk evaluation

Nemes-Nagy, Enikő; Fogarasi, Erzsébet; Croitoru, Mircea Dumitru; Preg, Zoltán; Pál, Sándor; Nyulas, Kinga-Ilona; Pál, Tünde; Tripon, Robert Gabriel; Tilincă, Mariana; Germán-Salló, Márta

doi:10.2478/rrlm-2022-0025

Cited by 1 publication

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“…A similar inverse relationship between serum HDL-cholesterol and triglyceride concentration was obtained in another study of our research group, on a larger number of cases. 12 The inverse relationship between BMI and HDL-cholesterol is similar to the outcome of certain previous studies in the literature, 13,14 and it emphasizes the importance of weight loss to improve metabolic imbalance and protection against cardiovascular diseases.…”

Section: Discussionsupporting

confidence: 80%

Assessment of Vitamin D Levels in Relation to Statin Therapy in Elderly Hypertensive Patients with Comorbidities

Nyulas

Simon-Szabó

Preg

et al. 2022

Journal of Interdisciplinary Medicine

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Background: Statin therapy is commonly used on the long term in hypertensive patients with dyslipidemia and can interfere with vitamin D metabolism. Overweight/obesity and type 2 diabetes mellitus (DM) are frequently associated with hypertension. The aim of the study was the assessment of vitamin D status in elderly hypertensive patients with metabolic comorbidities with/without statin therapy, in relation to body mass index (BMI) and lipid profile parameters. Material and methods: The study group included 89 hypertensive patients (61 statin-treated) admitted to the Cardiovascular Rehabilitation Clinical Hospital in Târgu Mureș between 2019 and 2021. Vitamin D levels were measured by ELISA method, lipid profile parameters by photometric procedures. Calculated values were LDL-cholesterol and BMI. Results: Obesity and DM were present in association with hypertension in 51% of the subjects. A total of 89% of the enrolled hypertensive patients had hypovitaminosis D. Average serum vitamin D of the studied subjects was 14.27 ± 11.96 ng/mL. No significant difference was obtained in vitamin D levels depending on gender, the presence/absence of statin therapy, and DM as a comorbidity. A negative correlation was seen between serum HDL-cholesterol and triglyceride concentrations (r = –0.3988, p = 0.0008) and between HDL levels and BMI (r = –0.3114, p = 0.0475). Conclusions: Suboptimal vitamin D levels were present in the majority of the studied hypertensive patients regardless of the statin therapy, which reveals the importance of concomitant assessment of vitamin D levels, especially in elderly subjects presenting chronic metabolic comorbidities.

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Section: Discussionsupporting

confidence: 80%