Oxidative stress and metabolic responses to copper in freshwater- and seawater-acclimated killifish, Fundulus heteroclitus

Ransberry, Victoria E.; Morash, Andrea J.; Blewett, Tamzin A.; Wood, Chris M.; McClelland, Grant B.

doi:10.1016/j.aquatox.2015.02.013

Cited by 40 publications

(33 citation statements)

References 72 publications

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“…All other studies used bioassays to measure SOD activity in liver, gills, muscle, intestine, kidney, red blood cells, blood, spleen and whole fish. SOD activity in gill tissue decreased in all studies, irrespective of exposure to mixed metals in field studies or single metal in laboratory toxicity tests [49, 84, 110, 117]. Following Cd exposure in toxicity tests, responses in different tissues have been consistent across various tissues (e.g.…”

Section: Resultsmentioning

confidence: 93%

“…Controlled Cu exposures have resulted in decreased SOD activity in gills and liver [116], although responses can differ between tissues in one and the same species (e.g. no response in liver, negative response in gills and intestines) [49]. Activity of SOD in muscle tissue did not change significantly following Cu exposure [116].…”

Section: Resultsmentioning

confidence: 99%

“…Twenty eight studies have assessed the response of CAT activity to metal contamination, with seven being toxicity tests and 22 field assessments (S16 Table). Following controlled Cu exposure CAT activity did not change in gill tissues [49, 116]. In contrast, controlled Cd exposure resulted in a decrease in CAT activity in gill, liver and spleen tissue in Synechogobius hasta [117], but no response in gill, kidney or liver tissue in Paralicthys olivaceus [110].…”

Section: Resultsmentioning

confidence: 99%

“…Records that did not examine the effects of contaminants of concern on coastal and/or marine fish were subsequently removed. Studies on freshwater fish species were excluded given that the speciation and behaviour of metals, and consequently the uptake pathways and sites of bioaccumulation, differ markedly in fresh and marine waters [49–51]. Full text articles were obtained for the remaining records where possible, and assessed for eligibility for inclusion in the qualitative synthesis of the potential use of fish biomarkers for assessing fish health in Gladstone Harbour.…”

Section: Methodsmentioning

confidence: 99%

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A protocol for identifying suitable biomarkers to assess fish health: A systematic review

2017

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BackgroundBiomarkers have been used extensively to provide the connection between external levels of contaminant exposure, internal levels of tissue contamination, and early adverse effects in organisms.ObjectivesTo present a three-step protocol for identifying suitable biomarkers to assess fish health in coastal and marine ecosystems, using Gladstone Harbour (Australia) as a case study.MethodsPrior to applying our protocol, clear working definitions for biomarkers were developed to ensure consistency with the global literature on fish health assessment. First, contaminants of concern were identified based on the presence of point and diffuse sources of pollution and available monitoring data for the ecosystem of interest. Second, suitable fish species were identified using fisheries dependent and independent data, and prioritised based on potential pathways of exposure to the contaminants of concern. Finally, a systematic and critical literature review was conducted on the use of biomarkers to assess the health of fish exposed to the contaminants of concern.Results/DiscussionWe present clear working definitions for bioaccumulation markers, biomarkers of exposure, biomarkers of effect and biomarkers of susceptibility. Based on emission and concentration information, seven metals were identified as contaminants of concern for Gladstone Harbour. Twenty out of 232 fish species were abundant enough to be potentially suitable for biomarker studies; five of these were prioritised based on potential pathways of exposure and susceptibility to metals. The literature search on biomarkers yielded 5,035 articles, of which 151met the inclusion criteria. Based on our review, the most suitable biomarkers include bioaccumulation markers, biomarkers of exposure (CYP1A, EROD, SOD, LPOX, HSP, MT, DNA strand breaks, micronuclei, apoptosis), and biomarkers of effect (histopathology, TAG:ST).ConclusionOur protocol outlines a clear pathway to identify suitable biomarkers to assess fish health in coastal and marine ecosystems, which can be applied to biomarker studies in aquatic ecosystems around the world.

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Section: Resultsmentioning

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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A protocol for identifying suitable biomarkers to assess fish health: A systematic review

2017

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“…Several previous studies have demonstrated an elevation in branchial LDH activity as a result of exposure to pesticides, heavy metals, and other toxicants (Ransberry et al, 2015;Raj and Joseph, 2015). However, there is little information regarding the effect of cyanobacterial neurotoxins or PSPs on LDH activity in fish gills.…”

Section: Changes In Ldh Activity In the Gills Of Aphantoxin-exposed Zmentioning

confidence: 95%

In vivo effects of Aphanizomenon flos-aquae DC-1 aphantoxins on gas exchange and ion equilibrium in the zebrafish gill

et al. 2016

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A broader look at ammonia production, excretion, and transport in fish: a review of impacts of feeding and the environment

Bucking

2016

J Comp Physiol B

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For nearly a century, researchers have studied ammonia production and excretion in teleost fish. Stemming from past investigations a body of knowledge now exists on various aspects including biochemical mechanisms of ammonia formation and specific routes and tissues used for ammonia transport, culminating in a current detailed theoretical model of branchial transport, including the molecular identities of the moieties involved. However, typical studies examining ammonia balance use routine laboratory conditions and fasted fish. While avoiding additional variables that influence nitrogen balance, these studies are arguably idealistic and do not reflect the natural variety of conditions that fish encounter. Further studies have revealed the impacts of extrinsic factors (e.g. salinity, pH, temperature) on ammonia handling in fasted fish whereas others have explored intrinsic factors, such as life history and developmental impacts. One routine challenge for ammonia balance that fish encounter is feeding and digestion. Fortunately, many new studies have revealed the impact of feeding and digestion on several aspects of ammonia balance; from production to excretion and to transport, and several have done so incorporating supplemental extrinsic and/or intrinsic factors. Together, these complex studies reveal realistic responses to multifactorial challenges encountered by animals in the wild and begin to provide a holistic view of ammonia balance in freshwater teleost fish.

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Oxidative stress and metabolic responses to copper in freshwater- and seawater-acclimated killifish, Fundulus heteroclitus

Cited by 40 publications

References 72 publications

A protocol for identifying suitable biomarkers to assess fish health: A systematic review

A protocol for identifying suitable biomarkers to assess fish health: A systematic review

In vivo effects of Aphanizomenon flos-aquae DC-1 aphantoxins on gas exchange and ion equilibrium in the zebrafish gill

A broader look at ammonia production, excretion, and transport in fish: a review of impacts of feeding and the environment

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