Oxidative stress and mitochondrial dysfunction in organophosphate pesticide-induced neurotoxicity and its amelioration: a review

Farkhondeh, Tahereh; Forouzanfar, Fatemeh; Roshanravan, Babak; Samarghandian, Saeed

doi:10.1007/s11356-020-09045-z

Cited by 109 publications

(49 citation statements)

References 118 publications

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“…However, Azevedo et al [110] also observed that the higher concentration of pyriproxyfen (0.1 µg/mL) reduced the Ca 2+ uptake into the cell interior, which could be related to a loss of mitochondrial membrane potential, or a damage of the ER caused by the pesticide. These results are in line with the extensive evidence pointing to the mitochondria as one of the targets of neurotoxic action exerted by pesticides [116][117][118][119].…”

Section: Effects On Intracellular Ca 2+ Storessupporting

confidence: 89%

Systematic Review of Calcium Channels and Intracellular Calcium Signaling: Relevance to Pesticide Neurotoxicity

Costas-Ferreira

Faro

2021

IJMS

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Pesticides of different chemical classes exert their toxic effects on the nervous system by acting on the different regulatory mechanisms of calcium (Ca2+) homeostasis. Pesticides have been shown to alter Ca2+ homeostasis, mainly by increasing its intracellular concentration above physiological levels. The pesticide-induced Ca2+ overload occurs through two main mechanisms: the entry of Ca2+ from the extracellular medium through the different types of Ca2+ channels present in the plasma membrane or its release into the cytoplasm from intracellular stocks, mainly from the endoplasmic reticulum. It has also been observed that intracellular increases in the Ca2+ concentrations are maintained over time, because pesticides inhibit the enzymes involved in reducing its levels. Thus, the alteration of Ca2+ levels can lead to the activation of various signaling pathways that generate oxidative stress, neuroinflammation and, finally, neuronal death. In this review, we also discuss some proposed strategies to counteract the detrimental effects of pesticides on Ca2+ homeostasis.

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Section: Effects On Intracellular Ca 2+ Storessupporting

confidence: 89%

Systematic Review of Calcium Channels and Intracellular Calcium Signaling: Relevance to Pesticide Neurotoxicity

Costas-Ferreira

Faro

2021

IJMS

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“…Pesticides can disturb the function of mitochondria 53 and mitochondrial dysfunction either by the development of oxidative injury factors that lead to the hyperphosphorylation of tau and/ or by decreased metabolism, also leading to tau hyperphosphorylation, and tau aggregation may represent one of the pathomechanisms of PSP (Figure 2). Therefore, it is biologically plausible that exposure to pesticides is associated with an increased risk for PSP.…”

Section: Residential Areasmentioning

confidence: 99%

Environmental Risk Factors for Progressive Supranuclear Palsy

Park¹,

Ilango²,

Litvan³

2021

JMD

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Typically, progressive supranuclear palsy (PSP) is clinically characterized by slow vertical saccades or supranuclear gaze palsy, levodopa-resistant parkinsonism with predominant axial symptoms, and cognitive executive impairment. Over the past decades, various PSP phenotypes, including PSP with predominant parkinsonism, PSP with corticobasal syndrome, PSP with progressive gait freezing, and PSP with predominant frontal dysfunction, have been identified from pathologically confirmed cases. Expanding knowledge led to new diagnostic criteria for PSP that with increased disease awareness led to increased PSP prevalence estimates. The identification of environmental and modifiable risk factors creates an opportunity to intervene and delay the onset of PSP or slow disease progression. To date, despite the increasing number of publications assessing risk factors for PSP, few articles have focused on environmental and lifestyle risk factors for this disorder. In this article, we reviewed the literature investigating the relationship between PSP and several environmental and other modifiable lifestyle risk factors. In our review, we found that exposures to toxins related to diet, metals, well water, and hypertension were associated with increased PSP risk. In contrast, higher education and statins may be protective. Further case-control studies are encouraged to determine the exact role of these factors in the etiopathogenesis of PSP, which in turn would inform strategies to prevent and reduce the burden of PSP.

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“…The side groups are variable and occur through the bond with phosphorus or directly (Phosphinates), through oxygen (phosphates), or nitrogen (phosphoramidites). The X substituent or leaving group is separated and hydrolyzed to release the enzyme after the organophosphorus phosphorylates acetylcholinesterase (4).…”

Section: Introductionmentioning

confidence: 99%

“…Organophosphate toxin inhibits cholinesterase by phosphorylation of hydroxyl serine in the enzyme (1). Inhibition of acetylcholinesterase activity in blood, brain, and tissues is time-dependent (4). The extent of acetylcholinesterase inhibition depends on the constant amount of enzyme and the binding time of the toxin.…”

Section: Introductionmentioning

confidence: 99%

The relationship of hs-CRP, vitronectin and NT-proBNP serum levels with the extent and severity of cardiac complications in patients with organophosphate pesticide poisoning

You-gui

Sun

Han

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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Acute organophosphate poisoning kills tens of thousands of people annually around the world. These substances are widely used as insecticides in homes, industry, and agricultural environments. Due to the ease of access, they can cause accidental or intentional risks of exposure through the skin or respiratory contact. This study aimed to evaluate the serum levels of hs-CRP, Vitronectin, and NT-proBNP and their relationship with the extent and severity of cardiac complications in patients with organophosphate pesticide poisoning. In this descriptive-comparative study, 160 patients were studied with acute organophosphate poisoning. Also, for better comparison, 40 healthy individuals participated in this study. Diagnosis of organophosphate poisoning was based on clinical findings of serum butyrylcholinesterase levels. The hs-CRP measurement was performed by an autoanalyzer (Abbott, model Alcyon 300, USA) with the ELISA hs-CRP kit (The apDia Company, Belgium). Vitronectin (VN) measurements were performed by ELISA method and Glory science human VN kit with Catalog No: 11668. NT-ProBNP serum levels were analyzed by ProBNP assay kit (Roche, Germany) by ECLIA method using Elecsys 2010 Analyzer. The most important variables studied in this study were the electrical activity and conduction system of the heart, PR distance, QTC interval, and T-wave changes. In this study, most of the patients were women and girls (60.78%). The highest percentage of organophosphate poisoning was in the age group of 15-24 years (37.25%). In most cases (78.43%), poisoning was intentional or suicidal. Evaluation of electrophysiological abnormalities of the heart showed that 89 patients (55.62%) had long QTC interval (>450 msec), 43 cases (26.87%) had possible long QTC (431-450 msec), and 28 cases (17.5%) had normal QTC (<430 msec). Only 9.37% of cases (n = 15) showed an increase in P-R distance, which is characteristic of the first-degree ventricular atrial block. Sinus bradycardia occurred in 57 cases (35.62%) and sinus tachycardia in 43 cases (26.87%); in 60 cases (37.5%), the pulse rate was normal. Smooth T-wave changes were observed in 9.8% of patients and reverse T-wave was observed in 17.6%. A long T-wave was not reported in any case. In only two cases (1.25%) was grade 1 ventricular atrial block and grade 2 and 3 blocks were not observed. In general, there was a significant difference in the hs-CRP, vitronectin, and NT-proBNP serum levels between the patient and control groups in all studied variables. These parameters were also related to the extent and severity of the disease.

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Oxidative stress and mitochondrial dysfunction in organophosphate pesticide-induced neurotoxicity and its amelioration: a review

Cited by 109 publications

References 118 publications

Systematic Review of Calcium Channels and Intracellular Calcium Signaling: Relevance to Pesticide Neurotoxicity

Systematic Review of Calcium Channels and Intracellular Calcium Signaling: Relevance to Pesticide Neurotoxicity

Environmental Risk Factors for Progressive Supranuclear Palsy

The relationship of hs-CRP, vitronectin and NT-proBNP serum levels with the extent and severity of cardiac complications in patients with organophosphate pesticide poisoning

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